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CS1

General Information
Protegen ID 79
Sequence Strain (Species/Organism) Escherichia coli 536
VO ID VO_0010941
Taxonomy ID 362663
Molecule Role Protective antigen
Molecule Role Annotation ETEC also expresses a range of colonisation factor antigens (CFAs), which allow adherence to the mucosal surface and therefore colonisation of the intestine. Some CFAs are sub-divided into coli surface (CS) antigens (Daley et al., 2007).
Related Vaccines(s) EHEC O157 subunit vaccine using his-tagged N-terminal intimin , Live attenuated ETEC vaccine ACAM2017 , Shiga Toxin 2 B Subunit Vaccine
References
Daley et al., 2007: Daley A, Randall R, Darsley M, Choudhry N, Thomas N, Sanderson IR, Croft N, Kelly P. Genetically modified enterotoxigenic escherichia coli vaccines induce mucosal immune responses without inflammation. Gut. 2007 Jun 12; ; . [PubMed: 17566016].
Gene Information
Gene Name CS1
NCBI Gene ID 4188469
Genbank Accession CP000247
Locus Tag ECP_3188
Gene Starting Position 3361397
Gene Ending Position 3361897
DNA Sequence 
>NC_008253.1:3361397-3361897 Escherichia coli 536, complete genome
ATTAGAGAGCCTGGGACAGATAAATGCTAACTACGCCACGGTAGATACCCGTTTCCAGAACACCTTTGGT
AGCCTGGGAAAACATCAGTGGTTTAGCCAGCGAACCGTTAGTTAACGCATCGGAAGCAAAGATTTTCGTT
GCGGTAAACGTGGTTGCCGCATCAGCAGCAATCACTTCACCACCCCAGGTTACGGTCAGCGGAACAATTT
TGCTGGCGTCCACGCTCTGAACCAGTTGCGCAGGCGAAACTAACTGCATTTTCACGTCTTTGGTCGTGTC
ATTTGACCAGATTTTAGTCATTAACTGGTAAGATTGCAGACCCTGACCTGGCAGATATTGCATTTCTACT
GCCTTCGGCAGTGCAGTATTATCGGTCTGCGTCATATCCAGAGCAGCATCAACGTTAGCAGTAACAGTGA
TATCTTTTTGTACTGCTAATGCAGAACCTGCAACGGAAAACATTGCCGCTACCAGAAGAGATTTTGCGAA
TACCTTTTTCA
Protein Information
Protein Name CS1 type fimbrial major subunit
NCBI Protein GI 110643341
Protein Accession YP_671071
Protein pI 8.86
Protein Weight 15880.12
Protein Length 166
Protein Note CS1 type firmbrial major subunit; CS1 pili; coli surface antigen 1
Protein Sequence 
>YP_671071.1 CS1 type fimbrial major subunit [Escherichia coli 536]
MKKVFAKSLLVAAMFSVAGSALAVQKDITVTANVDAALDMTQTDNTALPKAVEMQYLPGQGLQSYQLMTK
IWSNDTTKDVKMQLVSPAQLVQSVDASKIVPLTVTWGGEVIAADAATTFTATKIFASDALTNGSLAKPLM
FSQATKGVLETGIYRGVVSIYLSQAL
Vaxign Prediction
Localization(Probability) Extracellular
(Prob.=0.972)
Adhesin Probability 0.802
Trans-membrane Helices 0
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope