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gEh29

General Information
Protegen ID 791
Sequence Strain (Species/Organism) Entamoeba histolytica
VO ID VO_0011322
Taxonomy ID 5759
Other Database IDs CDD:223527
CDD:239313
GOA:P19476
InterPro: IPR000866
InterPro: IPR012335
InterPro: IPR012336
InterPro: IPR017936
InterPro: IPR019479
UniProtKB/UniProt: P19476
Molecule Role Protective antigen
Molecule Role Annotation 80% of C3H/HeJ mice immunized with Eh29 administered in combination with a subclinical dose of whole cholera toxin, but not as an Eh29-CTxB fusion, showed no evidence of infection in tissue sections harvested following intracecal challenge with virulent E. histolytica trophozoites. These results suggest that Eh29 is capable of inducing protective anti-amoebic immune responses in mice following oral immunization and could be used in the development of oral vaccines against amoebiasis (Carrero et al., 2010).
Related Vaccines(s) E. histolytica Eh29 protein vaccine
References
Carrero et al., 2010: Carrero JC, Contreras-Rojas A, Sánchez-Hernández B, Petrosyan P, Bobes RJ, Ortiz-Ortiz L, Laclette JP. Protection against murine intestinal amoebiasis induced by oral immunization with the 29kDa antigen of Entamoeba histolytica and cholera toxin. Experimental parasitology. 2010; ; . [PubMed: 20303954].
Gene Information
Gene Name gEh29
NCBI Nucleotide GI 399673
DNA Sequence 
>gi|399673|emb|X70996.1| E.histolytica gEh29 gene for alkyl-hydroperoxidase reductase
TTAGTTAAAAAGTATTTGATGACTTATTAGTTCATGTTACATATACAAAAATAATACTTTTATTGAAGTT
TTGTGCCAATACATTTCTCTTTCTCCTCATCATATTCTTCATTAGATTCTTTGAGAATGTGTGGATGTGT
GTATCTCCGTTTTCTTCTTTTTATCTAGTCATTTTTGTTTTCTATTTACCAGTTCTTTCATTATAAGTTG
TTTAAATGTTGAATAATTACCATAATGAGAATAATGCAGAAGTGATGATGACGACATTTTTATTTTAGTT
AAGTAAAGATGATTTTGGTAGTTCATTTGTCATTTAAACATCTCATCATCACCACAATCTCATCAATTCA
ATCAGTCAAATGTCTTGCAATCAACAAAAAGAGTGTTGTAAAAAAGAATGTCAAGAGAAAGAATGTTGTA
AAGAATGTTGTTGTCCAAGAATAAAAGCATTTAAGAAATTTATAAACACATTTGAAAAAGCACAAATTGG
AAAAGAAGCACCAGAATTTAAAGCACCAGCATATTGTCCATGTGGTTCAATCAAAGAGATTGATATTAAT
GAATATAGAGGAAAATATGTTGTATTGTTGTTTTATCCATTGGATTGGACATTTGTTTGTCCAACAGAAA
TGATTGGATATAGTGAACTTGCAGGACAATTGAAAGAAATCAATTGTGAAGTTATTGGAGTGAGTGTAGA
TTCAGTTTATTGTCATCAAGCATGGTGTGAAGCAGATAAAAGTAAAGGAGGAGTAGGAAAGTTGACATTC
CCATTAGTATCAGATATTAAGAGATGCATTTCTATCAAATATGGAATGTTAAATGTCGAAGCAGGAATTG
CAAGAAGAGGATATGTCATCATTGACGATAAAGGAAAAGTAAGATACATTCAAATGAATGATGATGGAAT
TGGAAGATCAACGGAAGAAACAATCAGAATAGTGAAAGCAATTCAATTCAGTGATGAACATGGAGCAGTT
TGTCCACTCAATTGGAAACCAGGCAAAGACACCATTGAACCAACACCAGATGGAATTAAGAAATATTTAA
CAGCACATTAAAACAAACAAGATAATTTAATACAAATTATTTTATGTTTTATAAGAAGAAAATGATATAA
TAAAAGATAAA
Protein Information
Protein Name alkyl hydroperoxide reductase
NCBI Protein GI 399674
Protein Accession CAA50324.1
Protein pI 7.38
Protein Weight 25237.95
Protein Length 304
Protein Note Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]; COG0450
Protein Sequence 
>CAA50324.1 alkyl hydroperoxide reductase [Entamoeba histolytica]
MSCNQQKECCKKECQEKECCKECCCPRIKAFKKFINTFEKAQIGKEAPEFKAPAYCPCGSIKEIDINEYR
GKYVVLLFYPLDWTFVCPTEMIGYSELAGQLKEINCEVIGVSVDSVYCHQAWCEADKSKGGVGKLTFPLV
SDIKRCISIKYGMLNVEAGIARRGYVIIDDKGKVRYIQMNDDGIGRSTEETIRIVKAIQFSDEHGAVCPL
NWKPGKDTIEPTPDGIKKYLTAH
Epitope Information
IEDB Linear Epitope