VIOLIN Logo
VO Banner
Search: for Help
Protegen Home
Introduction
Statistics
News and Updates
Protegen Query
Protegen BLAST
Selected Bacteria
Brucella spp. (26)
B. anthracis (14)
E. coli (40)
M. tuberculosis (28)
N. meningitidis (18)
Selected Viruses
Ebola virus (19)
HIV (41)
Influenza virus (50)
Selected Parasites
Plasmodium (47)
Data Submission
Data Exchange
Data Download
Documentation
FAQs
Disclaimer
Contact Us
UMMS Logo


Gal/GalNAc lectin

General Information
Protegen ID 792
Sequence Strain (Species/Organism) Entamoeba histolytica HM-1:IMSS
VO ID VO_0011323
Taxonomy ID 294381
Molecule Role Protective antigen
Molecule Role Annotation Study tested if vaccination with the E. histolytica Gal/GalNAc lectin could prevent cecal infection in a C3H mouse model of amebic colitis. Vaccination prevented intestinal infection with efficacies of 84 and 100% in the two native lectin trials and 91 and 34% in the two LecA trials. Results show for the first time that immunization with the Gal/GalNAc lectin can prevent intestinal amebiasis in mice (Houpt et al., 2004).
Related Vaccines(s) E. histolytica Gal/GalNAc lectin protein vaccine
References
Houpt et al., 2004: Houpt E, Barroso L, Lockhart L, Wright R, Cramer C, Lyerly D, Petri WA. Prevention of intestinal amebiasis by vaccination with the Entamoeba histolytica Gal/GalNac lectin. Vaccine. 2004; 22(5-6); 611-617. [PubMed: 14741152].
Gene Information
Gene Name Gal/GalNAc lectin
NCBI Gene ID 3404842
Genbank Accession DS571321
Chromosome No Unknown
Locus Tag EHI_046650
Gene Starting Position 16307
Gene Ending Position 19930
DNA Sequence 
>NW_001915036.1:16307-19930 Entamoeba histolytica HM-1:IMSS scf_1104750517013 genomic scaffold, whole genome shotgun sequence
ATTATCCATTGAAATTAGCATTTGTGGCATTATCATCTTTAGCTGTGAATTGTGGGTTATTCACAGTATT
ATCAACAGTATTCTTTCTTGCAGAAATAACAATATCAACAGTTTGCTTAATTCCAATAGCAATAATTACC
ATAACAACAACAATTACTGCAACAACAACTGCAACAGTGGTACCAGCAGCAATAGCAGCTGTATTATCAA
CGTCTTGCCATAACAAACAAACAGCATCTTTATCAACCAATTCATCATTGATCTTACAATTACCACATGC
ATCTAATGAGAATCTATGATCTGCATAATCAGAGTACATTGTTAAAATCCACCCACTTTCAGATTGTAAT
GAACATTCACAATAGAAACAATTCTTAGCTGCTTTAGACATATTAGGGAATTGAATATCAATATCACATT
GAACAAAATTAGTTTCAATTTCTCCTGTTTCTTTGTCACAATAAGCGTCTTGACATTTATTCTTATAGAG
CAATGCTTTTTCATGTCCATCAATATTACTTGTCCATTTATGTGTTATCACTCCTTCAGTGATAGTTTCA
ACACAGGTATAATTATAACATTTATCAGTACAATCCCTATCATTAGATGGCTCATCACTACATTTTGTAA
ATTCCTTCTTGATACAATATCCTGTACTTGTATCACATTTACCTGTTAATGAAGCACACCCAACATCAGC
AGTATTTGATGAACAAATAGAATCATCATACACACCACTACATTTTGGAATACTTCCAGAAGCATCACAA
TTAGTTTTCATACAAATAACTTCTCCAGGTTTACTAGGAGGAAGTGATGGACAAATAGTGACATTAGTTG
GTTCACAAAGTTGGGATGTTCCAGTCTTTACTTGAATGAAACAATTATTAGTTGGATTACAATCTCCTTC
ATATTTACAATCCCCATCTGAACAAGTCATCTGATAAATATTTCCAGATGCATCTACTTGATTTGGACAT
TTATCAACAAGAGTAGACTCTTTATCCATTCCACTACAATACTTACATAAACTTTTTACCTTTTCTTCGT
TTGAATTCCATTCACATTTATATTCATCAAATGTTGTGCCAATAATTAATTTGTAATCAAGAACATCAAG
ACATTTACTAGGGAAATTCTCATGTTTAGTACAATCAAATTCATCATCAATATGACAACTTCCATCACGA
CATACATATGGAATACCATTTATATTCTTTTTATTAGTACAATCCATTTTAATAAGTTTAGCTGGGTCAA
CAAGAATATTATCATATGAACAATACATACACTGACTATCTAAAATAACTTTTGATCCATCTTTTACAAT
AACTTTACATTCTCCATTTGCATATTCCCATTCATAATATTGTTCACAATCACTTAATCTATCTTTGAAA
AGATCTTTACAATCATATTCATCTGGTGCTTGACATTCTCCATCTTTACAAACAAATGGAATTCCTTGTG
ATGTAGTCAAACCTTCACATTTATTAACAATTTCATTTCCATCACAAATTTTACATTCTTGAATTGCTTT
ATCTGTAGTTACAAGTATACATTCTCTATTTCCACTACATACATAATTAGCATATCCATCACATTTTTCA
GGTACTTTTTCTTTACATACATATTCCTCTTGGTCTACAACATATTGAGTCGTTCCATTAGCAGTATATT
CTTTACAGACTTTTTTGTAACAACCTTCCCAAACAATATCATGTCCTTTAAGCTCTTCACAATTATCAAC
ATTAATACATTTTGGATCCCCATCTGTATAATCACAAACTTCGCCATTAGTACATCCATTACTAGTATCA
CATTTACATTGATATGATGTAGATGCATCACATCGACAATTTCCATTAACTTTCCCACACACTTTCATTC
CAGAACTACATCCAACTAAATTCATAACACAATTTCCAGTTTCACTATCACATGTAGCTTCATAACATGG
ATTTTCTTCATATGGAGATACTTTAATACATTTCTTTTCTTGAACCATACATGTTCCAGCAGAACAATAA
TATTCTTCACACTTACTTGATAATTTAGGACAATAGCTAGATGATTGTAATGTATTTGGAATACATTCTC
CATTTGTTCTATCACATGAATAAGTTCTACAAACAAATTTTTCTACTCCAGATTCAATAATTGAAGATGG
CTTAATATCATCAGTACAATTACTTCTAAAAGCACAGTTGTTTCCTGAACAATAAGGCTCTAAACATTTA
ACTGTTGAAACACATTTATTTTGTTCAATAGTACATCCAATATCTTCAACACATTTAGCTACACCTAAAC
AACTTTCTGTTGTACATTTTCTTTTTTCAATTTTATGATCAGCACTTGGATAATAAACACATTCTCCATT
TTCAGTATTACATGTTGTATAATAACATTCACTATGACAACACATTGGACATGTACAACGAGCCCCACCA
TCACAAAATCCTTTACAAGTTTTTCTATCACATAATTCAGTATTATTTGCCATAATAGTATTATATAATT
GTGGAAGAGAAGTGCTTAATGATGAAACAGATGATTTAAAGTAATGTTCCCCTTTATTAACTAATTCTTC
AAGTTGATATTCTTCTTCAATTGATGAGTCTAAATTAAATACATAAAATGTAGTATTATGACTATAAAGA
GTATTTAACATATTAGAAGCTTTTCCTGCATATTTACTGATATAAACAATATTCTTTCCTGCTTTTGAAG
ACATTTGGTTATATACAGTTTCTATAGCTTTTGTTTCATTTCCTTTTCTCATAACAGTAATTCCATTTAA
TACATTTTTAATATTATCCTTTGTTACTAATGAATCTGAATGATATGGATTTTGAGAGTTAATATAATAA
GCGAATGAAGTATCATTTGGGAATAAATCAATCAAATAATTAACAATTGAACTAAATATATTTCTTAATG
TATTAGTCATATCTAAATTAACAACAATACCAACCGCCATATTATTTGTTGGTGGTAAAACAGTAGAAGC
ATGACATTTAGTAATATTATTATTTTTATAGTCAGTGATAAAATTATCAGAAAATTCTGAACTACTTCTA
AATGTAATAACTTTACCTCCAATATATTCAAATCTACATGGTGACATTCCTTCTGCATATTTATTTGTTA
CATCATATGTTTTTTCAAGAAAATATGCAGCTGTTAATGGTGGTTTAGCAGCATATTTATAACAAGTTAA
TCCATTAATTGAAACAACTGGTAATTTAGAAGTATCTGATGGAATACGAGACCAATCCAATTGATATTCT
CTAATAGGATATCCCATTTTCTTTCTACACATATTTTCTTCTTTTGTATCACTTTTATCACGGTCATAAT
CTTGATTAAATATCATTTCAGTAAAATATTTACTTTGGTCTTTAGTAGGAAAATTACTATCAATAGTTGT
CCATTCTAAATTTCTCCATGGTTGCATTGTTAAATAATAAAATACACTATACTTTTTATTTACACTTCTT
GACCATGAAGCTGCATTTTTACCCATTCCCATTCTTCCTTTATCTTGGATATCTACAGTTCCAGAAAACT
CATTTAAATTAATTCCTAAAGCAATTGAAGCATAAAATAATACCAAAATTATCA
Protein Information
NCBI Protein GI 67469085
Protein Accession XP_650534
Protein pI 4.63
Protein Weight 126939.55
Protein Length 1207
Protein Note transcript EHI_046650A
Protein Sequence 
>XP_650534.1 Gal/GalNAc lectin heavy subunit, putative [Entamoeba histolytica HM-1:IMSS]
MIILVLFYASIALGINLNEFSGTVDIQDKGRMGMGKNAASWSRSVNKKYSVFYYLTMQPWRNLEWTTIDS
NFPTKDQSKYFTEMIFNQDYDRDKSDTKEENMCRKKMGYPIREYQLDWSRIPSDTSKLPVVSINGLTCYK
YAAKPPLTAAYFLEKTYDVTNKYAEGMSPCRFEYIGGKVITFRSSSEFSDNFITDYKNNNITKCHASTVL
PPTNNMAVGIVVNLDMTNTLRNIFSSIVNYLIDLFPNDTSFAYYINSQNPYHSDSLVTKDNIKNVLNGIT
VMRKGNETKAIETVYNQMSSKAGKNIVYISKYAGKASNMLNTLYSHNTTFYVFNLDSSIEEEYQLEELVN
KGEHYFKSSVSSLSTSLPQLYNTIMANNTELCDRKTCKGFCDGGARCTCPMCCHSECYYTTCNTENGECV
YYPSADHKIEKRKCTTESCLGVAKCVEDIGCTIEQNKCVSTVKCLEPYCSGNNCAFRSNCTDDIKPSSII
ESGVEKFVCRTYSCDRTNGECIPNTLQSSSYCPKLSSKCEEYYCSAGTCMVQEKKCIKVSPYEENPCYEA
TCDSETGNCVMNLVGCSSGMKVCGKVNGNCRCDASTSYQCKCDTSNGCTNGEVCDYTDGDPKCINVDNCE
ELKGHDIVWEGCYKKVCKEYTANGTTQYVVDQEEYVCKEKVPEKCDGYANYVCSGNRECILVTTDKAIQE
CKICDGNEIVNKCEGLTTSQGIPFVCKDGECQAPDEYDCKDLFKDRLSDCEQYYEWEYANGECKVIVKDG
SKVILDSQCMYCSYDNILVDPAKLIKMDCTNKKNINGIPYVCRDGSCHIDDEFDCTKHENFPSKCLDVLD
YKLIIGTTFDEYKCEWNSNEEKVKSLCKYCSGMDKESTLVDKCPNQVDASGNIYQMTCSDGDCKYEGDCN
PTNNCFIQVKTGTSQLCEPTNVTICPSLPPSKPGEVICMKTNCDASGSIPKCSGVYDDSICSSNTADVGC
ASLTGKCDTSTGYCIKKEFTKCSDEPSNDRDCTDKCYNYTCVETITEGVITHKWTSNIDGHEKALLYKNK
CQDAYCDKETGEIETNFVQCDIDIQFPNMSKAAKNCFYCECSLQSESGWILTMYSDYADHRFSLDACGNC
KINDELVDKDAVCLLWQDVDNTAAIAAGTTVAVVVAVIVVVMVIIAIGIKQTVDIVISARKNTVDNTVNN
PQFTAKDDNATNANFNG
Epitope Information
IEDB Linear Epitope