Groups of C57BL/6 mice (20 per group) vaccinated with rPep1 (1 µg or 5 µg per dose) plus adjuvant and challenged with an intranasal inoculum began to die at about 14 to 16 days but then showed significantly greater survival than the control mice (Tarcha et al., 2006).
References
Tarcha et al., 2006a: Tarcha EJ, Basrur V, Hung CY, Gardner MJ, Cole GT. A recombinant aspartyl protease of Coccidioides posadasii induces protection against pulmonary coccidioidomycosis in mice. Infection and immunity. 2006; 74(1); 516-527. [PubMed: 16369008].
