VIOLIN: Vaccine Investigation and Online Information Network

PLB

General Information

Protegen ID

796

Sequence Strain (Species/Organism)

Coccidioides posadasii

VO ID

VO_0011327

Taxonomy ID

199306

Other Database IDs

CDD:214474
CDD:132842

Molecule Role

Protective antigen

Molecule Role Annotation

C57BL/6 mice immunized with rPlb showed a significant reduction of the fungal burden in their lungs at 90 days postchallenge compared to the control mice at 15 days (Tarcha et al., 2006).

References

Tarcha et al., 2006a: Tarcha EJ, Basrur V, Hung CY, Gardner MJ, Cole GT. A recombinant aspartyl protease of Coccidioides posadasii induces protection against pulmonary coccidioidomycosis in mice. Infection and immunity. 2006; 74(1); 516-527. [PubMed: 16369008].

Gene Information

Gene Name

PLB

Protein Information

Protein Name

phospholipase B

NCBI Protein GI

74486661

Protein pI

6.85

Protein Weight

65081.68

Protein Length

710

Protein Note

Cytoplasmic phospholipase A2, catalytic subunit; smart00022

Protein Sequence

>ABA12208.1 phospholipase B [Coccidioides posadasii]
MRPIGAAVNALLTAALLAGTAGASAIPLDSNVHIRALPNAPNGYTPANVPCPANRPTVRSAASVSPEEAR
WLEKRRKKAMSALAGFFGHVSIPDFDAVAYIGKYAENLAQLPNIGIAVSGGGYRALMNGAGAIKAFDSRT
AGSTSKGHLGGLLQSATYLSGLSGGGWLVGSLYLNNETSVDALTSGMEGKAWDFHRSIFQGPKFTGSTFL
DVLRYYAQLQSAVAGKQDAGYKVSITDYWGRALSYQFINAKEGGPSYTWSSISLSSDFQNAEYPMPIILA
DGRNPGEKLILGNATVFEFNPWEFGTFDPTIFGFVPLEYLGSKFQGGVLPSSESCVRGFDNAGYIMGTSS
SLFNEFALRLDEVDIPKFIKDELRKILKALGDENNDIADYSPNPFYQYATGTSPFAGVLSLPLVDGGEDG
QNIPLHPLIQPARKVDVIFAIDSSANTKNNWPNGSSLVAAYKRSLDPSGIANGTSFPAVPDVNTFVNLGL
NTRPTFFGCDSSNTTKPTPLVVYIPNYPYTTWSNISTFTLATPNETRDAIIKNGYDVATMGGTTGEKEWP
TCVGCAILSRSFERTGIAMPAACQECLKKHCWDGTVNSATPADYAPSVGPPSAGAKSAASARIRASPSKH
SVVVFSVVVLGIAASW

Epitope Information

IEDB Linear Epitope