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AMN1

General Information
Protegen ID 797
Sequence Strain (Species/Organism) Coccidioides posadasii
VO ID VO_0011328
Taxonomy ID 199306
Other Database IDs CDD:279825
Molecule Role Protective antigen
Molecule Role Annotation C57BL/6 mice immunized with rAMN1 showed a significant reduction of the fungal burden in their lungs at 90 days postchallenge compared to the control mice at 15 days (Tarcha et al., 2006).
References
Tarcha et al., 2006a: Tarcha EJ, Basrur V, Hung CY, Gardner MJ, Cole GT. A recombinant aspartyl protease of Coccidioides posadasii induces protection against pulmonary coccidioidomycosis in mice. Infection and immunity. 2006; 74(1); 516-527. [PubMed: 16369008].
Gene Information
Gene Name AMN1
Protein Information
Protein Name alpha-mannosidase 1
NCBI Protein GI 76786276
Protein pI 4.6
Protein Weight 54284.48
Protein Length 585
Protein Note Glycosyl hydrolase family 47; pfam01532
Protein Sequence 
>ABA54911.1 alpha-mannosidase 1 [Coccidioides posadasii]
MKGSPVLAVCAAALTLIPSVVALPMIDKDLPSSISQSSDKTSQERAEAVKDAFRFAWEGYLEHAFPNDEL
HPVSNTPGNSRNGWGASAVDALSTAIIMDMPDVVEKILDHISNIDYSQTDTMCSLFETTIRYLGGMISAY
DLLKGPGSHLVSDPAKVDVLLAQSLKLADVLKFAFDTKTGIPANELNITDKSTDGSTTNGLATTGTLVLE
WTRLSDITGDPEYGRLAQKGESYLLNPQPSSSEPFPGLVGRTIDIETGLFRDDYVSWGGGSDSFYEYLIK
MYVYDKGRFGKYKDRWVTAAESTIEHLKSSPSTRKDLTFVATYSGGRLGLNSGHLTCFDGGNFLLGGQIL
NRDDFTKFGLELVEGCYATYAATATKIGPEGFGWDATKVPEAQAEFYKEAGFYITTSYYNLRPEVIESIY
YAYRMTKDPKYQEWAWDAFVAINATTRTSTGFTAIGDVNTPDGGRKYDNQESFLFAEVMKYSYLIHSPEA
DWQVAGPGGTNAYVFNTEAHPVKVFSRGC
Epitope Information
IEDB Linear Epitope