VIOLIN: Vaccine Investigation and Online Information Network

ureB

General Information

Protegen ID

804

Sequence Strain (Species/Organism)

Helicobacter pylori

VO ID

VO_0011335

Taxonomy ID

210

Other Database IDs

CDD:184438

Molecule Role

Protective antigen

Molecule Role Annotation

Vaccination with poliovirus vector containing the gene for the B subunit of H. pylori urease provides significant prophylactic and strong therapeutic protection against H. pylori in mice (Smythies et al., 2005).

Related Vaccines(s)

H. pylori vaccine encoding UreB , SL3261- UreA and UreB

References

Smythies et al., 2005: Smythies LE, Novak MJ, Waites KB, Lindsey JR, Morrow CD, Smith PD. Poliovirus replicons encoding the B subunit of Helicobacter pylori urease protect mice against H. pylori infection. Vaccine. 2005; 23(7); 901-909. [PubMed: 15603891].

Gene Information

Gene Name

ureB

Protein Information

Protein Name

urease subunit alpha

NCBI Protein GI

WP_000724295

Protein pI

5.99

Protein Weight

58828.9

Protein Length

638

Protein Note

urease subunit beta; Provisional; PRK13985

Protein Sequence

>WP_000724295.1 urease subunit alpha [Helicobacter pylori]
MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLII
TNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFI
SPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNASNDASLADQ
IEAGAIGFKIHEDWGTTPSAINHALDVADKYDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGG
GHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTL
HDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGIS
EYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAHHGKAKYDAN
ITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPANKV
SLAQLFSIF

Epitope Information

IEDB Linear Epitope