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HtrA

General Information
Protegen ID 824
Sequence Strain (Species/Organism) Haemophilus influenzae NTHi 33
VO ID VO_0012376
Taxonomy ID 727
Other Database IDs CDD:273938
Molecule Role Protective antigen
Molecule Role Annotation rHtrA was found to be very immunogenic and partially protective in both the passive infant rat model of bacteremia and the active chinchilla model of otitis media (Loosmore et al., 1998).
References
Loosmore et al., 1998: Loosmore SM, Yang YP, Oomen R, Shortreed JM, Coleman DC, Klein MH. The Haemophilus influenzae HtrA protein is a protective antigen. Infection and immunity. 1998; 66(3); 899-906. [PubMed: 9488373].
Gene Information
Gene Name HtrA
Protein Information
Protein Name HtrA
NCBI Protein GI 2935168
Protein pI 7.66
Protein Weight 46698.16
Protein Length 513
Protein Note periplasmic serine protease, Do/DeqQ family; TIGR02037
Protein Sequence 
>AAC38203.1 HtrA [Haemophilus influenzae]
MKKTRFVLNSIALGLSVLSTSFVAQATLPSFVSEQNSLAPMLEKVQPAVVTLSVEGKAKVDSRSPFLDDI
PEEFKFFFGDRFAEQFGGRGESKRNFRGLGSGVIINASKGYVLTNNHVIDEADKITVQLQDGREFKAKLV
GKDELSDIALVQLEKPSNLTEIKFADSDKLRVGDFTVAIGNPFGLGQTVTSGIVSALGRSTGSDSGTYEN
YIQTDAAVNRGNSGGALVNLNGELIGINTAIISPSGGNAGIAFAIPSNQASNLVQQILEFGQVRRGLLGI
KGGELNADLAKAFNVSAQQGAFVSEVLPKSAAEKAGLKAGDIITAMNGQKISSFAEIRAKIATTGAGKEI
SLTYLRDGKSHDVKMKLQADDSSQLSSKTELPALDGATLKDYDAKGVKGIEITKIQPNSLAAQRGLKSGD
IIIGINRQMIENIRELNKVLETEPSAVALNILRGDSNFYLLVQ
Epitope Information
IEDB Linear Epitope