VIOLIN: Vaccine Investigation and Online Information Network

gltA

General Information

Protegen ID

827

Sequence Strain (Species/Organism)

Helicobacter pylori

VO ID

VO_0012379

Taxonomy ID

85962

Other Database IDs

CDD:180164
CDD:99867

Molecule Role

Protective antigen

Molecule Role Annotation

Mice were immunised with the citrate synthase protein by intra-Peyer's patch immunisation. Pre-immunisation with the citrate synthase protein led to a 84-91% reduction in H. pylori infection compared to unimmunised controls (Dunkley et al., 1999).

Related Vaccines(s)

H. pylori GltA Protein Vaccine

References

Dunkley et al., 1999: Dunkley ML, Harris SJ, McCoy RJ, Musicka MJ, Eyers FM, Beagley LG, Lumley PJ, Beagley KW, Clancy RL. Protection against Helicobacter pylori infection by intestinal immunisation with a 50/52-kDa subunit protein. FEMS immunology and medical microbiology. 1999; 24(2); 221-225. [PubMed: 10378424].

Gene Information

Gene Name

gltA

Protein Information

Protein Name

type II citrate synthase

NCBI Protein GI

NP_206828

Protein pI

8.03

Protein Weight

45749.59

Protein Length

500

Protein Note

type II citrate synthase; Reviewed; PRK05614

Protein Sequence

>NP_206828.1 type II citrate synthase [Helicobacter pylori 26695]
MSVTLVNNENNERYEFETIESTRGPKAVDFSKLFETTGFFSYDPGYSSTAGCQSKISYVNGKKGELYYRG
HRIEDLVAKYKYVDVCKLLLTGELPKNQDESLEFELELRHRSFVHESLLNMFSAFPSNAHPMAKLSSGVS
ILSTLYSTHQNMHTEEDYQTMARRIVAKIPTLAAICYRNEVGAPIIYPDIARSYVENILFMLRGYPYSRL
KHTTQGEVEITPLEVEAFDKILTLHADHSQNASSTTVRNVASTGVHPYAAISAGISALWGHLHGGANEKV
LLQLEEIGDVKNVDKYIARVKDKNDNFKLMGFGHRVYKSYDPRAKILKGLKDELHQKGVKMDERLSEIAA
KVEEIALKDEYFIERNLYPNVDFYSGTILRALKIPVRFFTPVFVIGRTVGWCAQLLEHVKSPQARITRPR
QVYVGD

Epitope Information

IEDB Linear Epitope