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LSA-3

General Information
Protegen ID 834
Sequence Strain (Species/Organism) Plasmodium falciparum 3D7
VO ID VO_0012381
Taxonomy ID 36329
Molecule Role Protective antigen
Molecule Role Annotation In chimpanzees (Pan troglodytes), the primates most closely related to humans and that share a similar susceptibility to P. falciparum liver-stage infection, immunization with LSA-3 induced protection against successive heterologous challenges with large numbers of P. falciparum sporozoites (Daubersies et al., 2000).
Related Vaccines(s) P. falciparum LSA-3 Protein Vaccine
References
Daubersies et al., 2000: Daubersies P, Thomas AW, Millet P, Brahimi K, Langermans JA, Ollomo B, BenMohamed L, Slierendregt B, Eling W, Van Belkum A, Dubreuil G, Meis JF, Guérin-Marchand C, Cayphas S, Cohen J, Gras-Masse H, Druilhe P. Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3. Nature medicine. 2000; 6(11); 1258-1263. [PubMed: 11062538].
Gene Information
Gene Name LSA-3
NCBI Gene ID 812783
Genbank Accession LN999943
Chromosome No 2
Locus Tag PF3D7_0220000
Gene Starting Position 796751
Gene Ending Position 801585
DNA Sequence 
>NC_037280.1:796751-801585 Plasmodium falciparum 3D7 chromosome 2, complete sequence
AATGACAAATAGTAATTACAAATCAAATAATAAAACATATAATGAAAATAATAATGAACAAATAACTACC
ATATTTAATAGAACAAATATGAATCCGATAAAAAAATGTCATATGAGAGAAAAAATAAATAAGTACTTTT
TTTTGATCAAAATTTTGACATGCACCATTTTAATATGGGCTGTACAATATGCTAATAACGTAAGATAAAA
AACTAAATAATAAATATAAATAAAAAAAAAAAAAAAAAAAAAAAAAATCAACTATATAGTATGTATAATA
TATATATATATATATATATATATATATTTATTTTTATTTATTTATTAATTTTTTTTTTTTTTATATTATC
TTTTTAGTCTGATATAAACAAGAGTTGGAAAAAAAATACGTATGTAGATAAGAAATTGAATAAACTATTT
AACAGAAGTTTAGGAGAATCTCAAGTAAATGGTGAATTAGCTAGTGAAGAAGTAAAGGAAAAAATTCTTG
ACTTATTAGAAGAAGGAAATACATTAACTGAAAGTGTAGATGATAATAAAAATTTAGAAGAAGCCGAAGA
TATAAAGGAAAATATCTTATTAAGTAATATAGAAGAACCAAAAGAAAATATTATTGACAATTTATTAAAT
AATATTGGACAAAATTCAGAAAAACAAGAAAGTGTATCAGAAAATGTACAAGTCAGTGATGAACTTTTTA
ATGAATTATTAAATAGTGTAGATGTTAATGGAGAAGTAAAAGAAAATATTTTGGAGGAAAGTCAAGTTAA
TGACGATATTTTTAATAGTTTAGTAAAAAGTGTTCAACAAGAACAACAACACAATGTTGAAGAAAAAGTT
GAAGAAAGTGTAGAAGAAAATGACGAAGAAAGTGTAGAAGAAAATGTAGAAGAAAATGTAGAAGAAAATG
ACGACGAAAGTGTAGCCTCAAGTGTTGAAGAAAGTATAGCTTCAAGTGTTGATGAAAGTATAGATTCAAG
TATTGAAGAAAATGTAGCTCCAACTGTTGAAGAAATCGTAGCTCCAACTGTTGAAGAAATTGTAGCTCCA
AGTGTTGTAGAAAGTGTGGCTCCAAGTGTTGAAGAAAGTGTAGAAGAAAATGTTGAAGAAAGTGTAGCTG
AAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAGTGTAGC
TGAAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAATCGTA
GCTCCAACTGTTGAAGAAAGTGTAGCTCCAACTGTTGAAGAAATTGTAGCTCCAAGTGTTGAAGAAAGTG
TAGCTCCAAGTGTTGAAGAAATTGTAGTTCCAACTGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAT
CGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAACTGTTGAAGAA
AGTGTAGCTCCAACTGTTGAAGAAATTGTAGCTCCAAGTGTTGAAGAAAGTGTAGCTCCAAGTGTTGAAG
AAATTGTAGTTCCAACTGTTGAAGAAAGTGTAGCTGAAAATGTTGAAGAAAGTGTAGCTGAAAATGTTGA
AGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTT
GAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTG
TTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCAAC
AGTTGAAGAAATCGTAGCTCCAACAGTTGAAGAAATTGTAGCTCCAAGTGTTGAAGAAATCGTAGCTCCA
ACTGTTGAAGAAAGTGTTGCTGAAAACGTTGCAACAAATTTATCAGACAATCTTTTAAGTAATTTATTAG
GTGGTATCGAAACTGAGGAAATAAAGGACAGTATATTAAATGAGATAGAAGAAGTAAAAGAAAATGTAGT
CACCACAATACTAGAAAACGTAGAAGAAACTACAGCTGAAAGTGTAACTACTTTTAGTAACATATTAGAG
GAGATACAAGAAAATACTATTACTAATGATACTATAGAGGAAAAATTAGAAGAACTCCACGAAAATGTAT
TAAGTGCCGCTTTAGAAAATACCCAAAGTGAAGAGGAAAAGAAAGAAGTAATAGATGTAATTGAAGAAGT
AAAAGAAGAGGTCGCTACCACTTTAATAGAAACTGTGGAACAGGCAGAAGAAGAGAGCGCAAGTACAATT
ACGGAAATATTTGAAAATTTAGAAGAAAATGCAGTAGAAAGTAATGAAAATGTTGCAGAGAATTTAGAGA
AATTAAACGAAACTGTATTTAATACTGTATTAGATAAAGTAGAGGAAACAGTAGAAATTAGCGGAGAAAG
TTTAGAAAACAATGAAATGGATAAAGCATTTTTTAGTGAAATATTTGATAATGTAAAAGGAATACAAGAA
AATTTATTAACAGGTATGTTTCGAAGTATAGAAACCAGTATAGTAATCCAATCAGAAGAAAAGGTTGATT
TGAATGAAAATGTGGTTAGTTCGATTTTAGATAATATAGAAAATATGAAAGAAGGTTTATTAAATAAATT
AGAAAATATTTCAAGTACTGAAGGTGTTCAAGAAACTGTAACTGAACATGTAGAACAAAATGTATATGTG
GATGTTGATGTTCCTGCTATGAAAGATCAATTTTTAGGAATATTAAATGAGGCAGGAGGGTTGAAAGAAA
TGTTTTTTAATTTGGAAGATGTATTTAAAAGTGAAAGTGATGTAATTACTGTAGAAGAAATTAAGGATGA
ACCGGTTCAAAAAGAGGTAGAAAAAGAAACTGTTAGTATTATTGAAGAAATGGAAGAAAATATTGTAGAT
GTATTAGAGGAAGAAAAAGAAGATTTAACAGACAAGATGATAGATGCAGTAGAAGAATCCATAGAAATAT
CTTCAGATTCTAAAGAAGAAACTGAATCTATTAAAGATAAAGAAAAAGATGTTTCACTAGTTGTTGAAGA
AGTTCAAGACAATGATATGGATGAAAGTGTTGAGAAAGTTTTAGAATTGAAAAATATGGAAGAGGAGTTA
ATGAAGGATGCTGTTGAAATAAATGACATTACTAGCAAACTTATTGAAGAAACTCAAGAGTTAAATGAAG
TAGAAGCAGATTTAATAAAAGATATGGAAAAATTAAAAGAATTAGAGAAAGCATTATCAGAAGATTCTAA
AGAAATAATAGATGCAAAAGATGATACATTAGAAAAAGTTATTGAAGAGGAACATGATATAACGACGACG
TTGGATGAAGTTGTAGAATTAAAAGATGTCGAAGAAGACAAGATCGAAAAAGTATCTGATTTAAAAGATC
TTGAAGAAGATATATTAAAAGAAGTAAAAGAAATCAAAGAACTTGAAAGTGAAATTTTAGAAGATTATAA
AGAATTAAAAACTATTGAAACAGATATTTTAGAAGAGAAAAAAGAAATAGAAAAAGATCATTTTGAAAAA
TTCGAAGAAGAAGCTGAAGAAATAAAAGATCTTGAAGCAGATATATTAAAAGAAGTATCTTCATTAGAAG
TTGAAGAAGAAAAAAAATTAGAAGAAGTACACGAATTAAAAGAAGAGGTAGAACATATAATAAGTGGTGA
TGCGCATATAAAAGGTTTGGAAGAAGATGATTTAGAAGAAGTAGATGATTTAAAAGGAAGTATATTAGAC
ATGTTAAAGGGAGATATGGAATTAGGGGATATGGATAAGGAAAGTTTAGAAGATGTAACAGCAAAACTTG
GAGAAAGAGTTGAATCCTTAAAAGATGTTTTATCTAGTGCATTAGGCATGGATGAAGAACAAATGAAAAC
AAGAAAAAAAGCTCAAAGACCTAAATTGGAAGAAGTATTATTAAAAGAAGAGGTTAAAGAAGAACCAAAG
AAAAAAATAACAAAAAAGAAAGTAAGGTTTGATATTAAGGATAAGGAACCAAAAGATGAAATAGTAGAAG
TTGAAATGAAAGATGAAGATATAGATGAAGATATAGAAGAAGATGTAGAAGAAGATATAGAAGAAGATAA
AGTTGAAGATATAGATGAAGATATAGATGAAGATATAGATGAAGATATAGGTGAAGACAAAGATGAAGTT
ATAGATTTAATAGTCCAAAAAGAGAAACGCATTGAAAAGGTTAAAGAGAAAAAGAAAAAATTAGAAAAAA
AAGTTGAAGAAGGTGTTAGTGGTCTTAAAAAACACGTAGACGAAGTAATGAAATATGTTCAAAAAATTGA
TAAAGAAGTTGATAAAGAAGTATCTAAAGCTTTAGAATCAAAAAATGATGTTACTAATGTTTTAAAACAA
AATCAAGATTTTTTTAGTAAAGTTAAAAACTTCGTAAAAAAATATAAAGTATTTGCTGCACCATTCATAT
CTGCCGTTGCAGCATTTGCATCATATGTAGTTGGGTTCTTTACATTTTCTTTATTTTCATCATGTGTAAC
AATAGCTTCTTCAACTTACTTATTATCAAAAGTTGACAAAACTATAAATAAAAATAAGGAGAGACCGTTT
TATTCATTTGTATTTGATATCTTTAAGAATTTAAAACATTATTTACAACAAATGAAAGAAAAATTTAGTA
AAGAAAAAAATAATAATGTAATAGAAGTAACAAACAAAGCTGAGAAAAAAGGTAATGTACAGGTAACAAA
TAAAACCGAGAAAACAACTAAAGTTGATAAAAATAATAAAGTACCGAAAAAAAGTAGAACGCAAAAATCA
AAATA
Protein Information
Protein Name Liver stage antigen 3
NCBI Protein GI 124801463
Protein Accession XP_001349701
Protein pI 3.86
Protein Weight 156020.34
Protein Length 1558
Protein Sequence 
>XP_001349701.1 liver stage antigen 3 [Plasmodium falciparum 3D7]
MTNSNYKSNNKTYNENNNEQITTIFNRTNMNPIKKCHMREKINKYFFLIKILTCTILIWAVQYANNSDIN
KSWKKNTYVDKKLNKLFNRSLGESQVNGELASEEVKEKILDLLEEGNTLTESVDDNKNLEEAEDIKENIL
LSNIEEPKENIIDNLLNNIGQNSEKQESVSENVQVSDELFNELLNSVDVNGEVKENILEESQVNDDIFNS
LVKSVQQEQQHNVEEKVEESVEENDEESVEENVEENVEENDDESVASSVEESIASSVDESIDSSIEENVA
PTVEEIVAPTVEEIVAPSVVESVAPSVEESVEENVEESVAENVEESVAENVEESVAENVEESVAENVEES
VAENVEESVAENVEEIVAPTVEESVAPTVEEIVAPSVEESVAPSVEEIVVPTVEESVAENVEEIVAPSVE
EIVAPSVEEIVAPTVEESVAPTVEEIVAPSVEESVAPSVEEIVVPTVEESVAENVEESVAENVEEIVAPS
VEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPSVEEIVAPTVEEIVA
PTVEEIVAPSVEEIVAPTVEESVAENVATNLSDNLLSNLLGGIETEEIKDSILNEIEEVKENVVTTILEN
VEETTAESVTTFSNILEEIQENTITNDTIEEKLEELHENVLSAALENTQSEEEKKEVIDVIEEVKEEVAT
TLIETVEQAEEESASTITEIFENLEENAVESNENVAENLEKLNETVFNTVLDKVEETVEISGESLENNEM
DKAFFSEIFDNVKGIQENLLTGMFRSIETSIVIQSEEKVDLNENVVSSILDNIENMKEGLLNKLENISST
EGVQETVTEHVEQNVYVDVDVPAMKDQFLGILNEAGGLKEMFFNLEDVFKSESDVITVEEIKDEPVQKEV
EKETVSIIEEMEENIVDVLEEEKEDLTDKMIDAVEESIEISSDSKEETESIKDKEKDVSLVVEEVQDNDM
DESVEKVLELKNMEEELMKDAVEINDITSKLIEETQELNEVEADLIKDMEKLKELEKALSEDSKEIIDAK
DDTLEKVIEEEHDITTTLDEVVELKDVEEDKIEKVSDLKDLEEDILKEVKEIKELESEILEDYKELKTIE
TDILEEKKEIEKDHFEKFEEEAEEIKDLEADILKEVSSLEVEEEKKLEEVHELKEEVEHIISGDAHIKGL
EEDDLEEVDDLKGSILDMLKGDMELGDMDKESLEDVTAKLGERVESLKDVLSSALGMDEEQMKTRKKAQR
PKLEEVLLKEEVKEEPKKKITKKKVRFDIKDKEPKDEIVEVEMKDEDIDEDIEEDVEEDIEEDKVEDIDE
DIDEDIDEDIGEDKDEVIDLIVQKEKRIEKVKEKKKKLEKKVEEGVSGLKKHVDEVMKYVQKIDKEVDKE
VSKALESKNDVTNVLKQNQDFFSKVKNFVKKYKVFAAPFISAVAAFASYVVGFFTFSLFSSCVTIASSTY
LLSKVDKTINKNKERPFYSFVFDIFKNLKHYLQQMKEKFSKEKNNNVIEVTNKAEKKGNVQVTNKTEKTT
KVDKNNKVPKKSRTQKSK
Epitope Information
IEDB Linear Epitope