VIOLIN: Vaccine Investigation and Online Information Network

phpA

General Information

Protegen ID

836

Sequence Strain (Species/Organism)

Streptococcus pneumoniae

VO ID

VO_0012383

Taxonomy ID

171101

Other Database IDs

CDD:273578
CDD:282170
CDD:293251

Molecule Role

Protective antigen

Molecule Role Annotation

Immunization with rPhpA-79 protein adjuvanted with monophosphoryl lipid A (for subcutaneous immunization) or a mutant cholera toxin, CT-E29H (for intranasal immunization), protected CBA/N mice against death and bacteremia, as well as reduced nasopharyngeal colonization, following intranasal challenge with a heterologous pneumococcal strain (Zhang et al., 2001).

Related Vaccines(s)

S. pneumoniae PhpA-79 Protein Vaccine

References

Zhang et al., 2001: Zhang Y, Masi AW, Barniak V, Mountzouros K, Hostetter MK, Green BA. Recombinant PhpA protein, a unique histidine motif-containing protein from Streptococcus pneumoniae, protects mice against intranasal pneumococcal challenge. Infection and immunity. 2001; 69(6); 3827-3836. [PubMed: 11349048].

Gene Information

Gene Name

phpA

Protein Information

Protein Name

histidine motif-containing protein

NCBI Protein GI

NP_358654

Protein pI

5.38

Protein Weight

92561.31

Protein Length

947

Protein Note

streptococcal histidine triad protein; TIGR01363

Protein Sequence

>NP_358654.1 histidine motif-containing protein [Streptococcus pneumoniae R6]
MNQIYLRKEERMKINKKYLAGSVATLVLSVCAYELGLHQAQTVKENNRVSYIDGKQATQKTENLTPDEVS
KREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIISEELLMKDPNYQLKDEDIISEIKGGYVIKV
DGKYYVYLKDAAHADNVRTKEEINRQKQEHSQHREGGTPRNDGAVALARSQGRYTTDDGYIFNASDIIED
TGDAYIVPHGDHYHYIPKNELSASELAAAKAFLSGRGNLSNSRTYRRQNSDNTSRTNWVPSVSNPGTTNT
NTSNNSNTNSQASQSNDIDSLLKQLYKLPLSQRHVESDGLIFDPAQITSRTANGVAVPHGDHYHFIPYSQ
LSPLEEKLARIIPLRYRSNHWVPDSRPEQPSPQSTPEPSPSPQPAPNPQPAPSNPIDEKLVKEAVRKVGD
GYVFEENGVPRYIPAKDLSAETAAGIDSKLAKQESLSHKLGAKKTDLPSSDREFYNKAYDLLARIHQDLL
DNKGRQVDFEALDNLLERLKDVSSDKVKLVDDILAFLAPIRHPERLGKPNAQITYTDDEIQVAKLAGKYT
TEDGYIFDPRDITSDEGDAYVTPHMTHSHWIKKDSLSEAERAAAQAYAKEKGLTPPSTDHQDSGNTEAKG
AEAIYNRVKAAKKVPLDRMPYNLQYTVEVKNGSLIIPHYDHYHNIKFEWFDEGLYEAPKGYSLEDLLATV
KYYVEHPNERPHSDNGFGNASDHVQRNKNGQADTNQTEKPNEEKPQTEKPEEETPREEKPQSEKPESPKP
TEEPEEESPEESPEESEEPQVETEKVKEKLREAEDLLGKIQNPIIKSNAKETLTGLKNNLLFGTQDNNTI
MAEAEKLLALLKESK

Epitope Information

IEDB Linear Epitope