VIOLIN: Vaccine Investigation and Online Information Network

OspB

General Information

Protegen ID

839

Sequence Strain (Species/Organism)

Borrelia burgdorferi B31

VO ID

VO_0012385

Taxonomy ID

224326

Molecule Role

Protective antigen

Molecule Role Annotation

Mice immunized with recombinant OspB protein were protected from challenge with Borrelia burgdorferi (Probert and LeFebvre, 1994).

Related Vaccines(s)

B. burgdorferi OspB Protein Vaccine

References

Probert and LeFebvre, 1994: Probert WS, LeFebvre RB. Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen. Infection and immunity. 1994; 62(5); 1920-1926. [PubMed: 8168958].

Gene Information

Gene Name

OspB

NCBI Gene ID

1194340

Genbank Accession

AE000790

Locus Tag

BB_A16

Plasmid No

lp54

Gene Starting Position

10287

Gene Ending Position

11177

DNA Sequence

>NC_001857.2:10287-11177 Borrelia burgdorferi B31 plasmid lp54, complete sequence
TATGAGATTATTAATAGGATTTGCTTTAGCGTTAGCTTTAATAGGATGTGCACAAAAAGGTGCTGAGTCA
ATTGGTTCTCAAAAAGAAAATGATCTAAACCTTGAAGACTCTAGTAAAAAATCACATCAAAACGCTAAAC
AAGACCTTCCTGCGGTGACAGAAGACTCAGTGTCTTTGTTTAATGGTAATAAAATTTTTGTAAGCAAAGA
AAAAAATAGCTCCGGCAAATATGATTTAAGAGCAACAATTGATCAGGTTGAACTTAAAGGAACTTCCGAT
AAAAACAATGGTTCTGGAACCCTTGAAGGTTCAAAGCCTGACAAGAGTAAAGTAAAATTAACAGTTTCTG
CTGATTTAAACACAGTAACCTTAGAAGCATTTGATGCCAGCAACCAAAAAATTTCAAGTAAAGTTACTAA
AAAACAGGGGTCAATAACAGAGGAAACTCTCAAAGCTAATAAATTAGACTCAAAGAAATTAACAAGATCA
AACGGAACTACACTTGAATACTCACAAATAACAGATGCTGACAATGCTACAAAAGCAGTAGAAACTCTAA
AAAATAGCATTAAGCTTGAAGGAAGTCTTGTAGGCGGAAAAACAACAGTGGAAATTAAAGAAGGTACTGT
TACTCTAAAAAGAGAAATTGAAAAAGATGGAAAAGTAAAAGTCTTTTTGAATGACACTGCAGGTTCTAAC
AAAAAAACAGGTAAATGGGAAGACAGTACTAGCACTTTAACAATTAGTGCTGACAGCAAAAAAACTAAAG
ATTTGGTGTTCTTAACAGATGGTACAATTACAGTACAACAATACAACACAGCTGGAACCAGCCTAGAAGG
ATCAGCAAGTGAAATTAAAAATCTTTCAGAGCTTAAAAACGCTTTAAAATA

Protein Information

Protein Name

outer surface protein B

NCBI Protein GI

365823348

Protein Accession

NP_045689

Protein pI

9.6

Protein Weight

30144.4

Protein Length

296

Protein Note

similar to GB:L23136 SP:P17739 GB:L23137 GB:L23138 GB:L23139 percent identity: 98.65; identified by sequence similarity; putative

Protein Sequence

>NP_045689.2 outer surface protein B (plasmid) [Borreliella burgdorferi B31]
MRLLIGFALALALIGCAQKGAESIGSQKENDLNLEDSSKKSHQNAKQDLPAVTEDSVSLFNGNKIFVSKE
KNSSGKYDLRATIDQVELKGTSDKNNGSGTLEGSKPDKSKVKLTVSADLNTVTLEAFDASNQKISSKVTK
KQGSITEETLKANKLDSKKLTRSNGTTLEYSQITDADNATKAVETLKNSIKLEGSLVGGKTTVEIKEGTV
TLKREIEKDGKVKVFLNDTAGSNKKTGKWEDSTSTLTISADSKKTKDLVFLTDGTITVQQYNTAGTSLEG
SASEIKNLSELKNALK

Epitope Information

IEDB Linear Epitope