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sib35

General Information
Protegen ID 855
Sequence Strain (Species/Organism) Streptococcus pyogenes serotype M12
VO ID VO_0012398
Taxonomy ID 342023
Other Database IDs CDD:286161
Molecule Role Protective antigen
Molecule Role Annotation Immunization with Sib 35 enhanced survival rates in mice challenged with a GAS strain, while exhibiting no toxicity in hosts (Okamoto et al., 2005).
Related Vaccines(s) S. pyogenes Sib35 Protein Vaccine
References
Okamoto et al., 2005: Okamoto S, Tamura Y, Terao Y, Hamada S, Kawabata S. Systemic immunization with streptococcal immunoglobulin-binding protein Sib 35 induces protective immunity against group: a Streptococcus challenge in mice. Vaccine. 2005; 23(40); 4852-4859. [PubMed: 15990202].
Gene Information
Gene Name sib35
Protein Information
Protein Name immunoglobulin-binding protein 35
NCBI Protein GI 90567992
Protein pI 7.68
Protein Weight 36275.97
Protein Length 431
Protein Note Mac 1; pfam09028
Protein Sequence 
>BAE92207.1 immunoglobulin-binding protein 35 [Streptococcus pyogenes serotype M12]
MRKRCYSTSAAVLAAVTLFVLSVDRGVIADSFSANQEIRYSEVTPYHVTSVWTKGVTPPAKFTQGEDVFH
APYVAKQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNNEKIEAYLKKHPDKQKIMFGDQELLDVRKV
INTKGDQTNSELFNYFRDKAFPGLSARRIGVMPDLVLDMFINGYYLNVYKTQTTDVNRTYQEKDRRGGIF
DAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNGNLE
AIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQTN
Epitope Information
IEDB Linear Epitope