VIOLIN: Vaccine Investigation and Online Information Network

GlpQ

General Information

Protegen ID

856

Sequence Strain (Species/Organism)

Treponema pallidum subsp. pallidum str. Nichols

VO ID

VO_0012399

Taxonomy ID

243276

Molecule Role

Protective antigen

Molecule Role Annotation

Immunization with the recombinant GlpQ significantly protected rabbits from subsequent T. pallidum challenge, altering lesion development at the sites of challenge (Cameron et al., 1998).

Related Vaccines(s)

T. pallidum GlpQ Protein Vaccine

References

Cameron et al., 1998: Cameron CE, Castro C, Lukehart SA, Van Voorhis WC. Function and protective capacity of Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase. Infection and immunity. 1998; 66(12); 5763-5770. [PubMed: 9826352].

Gene Information

Gene Name

GlpQ

NCBI Gene ID

2611763

Genbank Accession

AE000520

Locus Tag

TP_RS01315

Gene Starting Position

268189

Gene Ending Position

269259

DNA Sequence

>NC_000919.1:268189-269259 Treponema pallidum subsp. pallidum str. Nichols complete genome
TATGCGGGGAACATATTGTGTGACGCTTTGGGGGGGGGTGTTTGCGGCATTGGTTGCAGGCTGTGCGTCC
GAACGTATGATAGTTGCGTATCGGGGCGCTGCAGGATATGTGCCCGAGCACACCTTTGCCTCGAAAGTTC
TTGCTTTTGCACAAGGAGCAGATTACCTGCAGCAGGATGTCGTGCTTTCAAAGGATAATCAGCTTATCGT
AGCGCAAAGCCATATTCTGGATAATATGACTGACGTGGCAGAAAAATTTCCACGCCGGCAGCGTGCGGAT
GGGCATTTCTATGTCATAGATTTTACGGTAGAAGAACTTTCCCTCCTCCGTGCAACCAATAGTTTCTATA
CGCGCGGTAAGCGACATACGCCGGTGTATGGCCAGCGCTTTCCTCTTTGGAAGCCTGGTTTTAGGCTGCA
CACTTTTGAAGAGGAGTTGCAGTTTATCCGTGGGTTGGAACAGACAACCGGGAAAAAGATTGGAATTTAC
TCTGAAATAAAGGTGCCGTGGTTTCATCATCAGGAAGGAAAAGACATCGCAGCGCTTACCCTCGCTCTGT
TGAAAAAATACGGTTACCAAAGTCGATCGGATCTAGTGTATGTGCAAACGTATGATTTTAACGAGCTGAA
GCGTATCAAACGAGAACTTTTACCAAAGTACGAAATGAACGTGAAGCTGATTCAGCGTGTTGCTTACACA
GATCAACGTGAAACACAGGAGAAGGACTCGCGTGGGAAATGGATAAACTACAATTACAATTGGATGTTTG
AGCCCGGTGGTATGCAGAAAATAGCAAAATATGCAGACGGCGTGGGTCCTGACTGGAGGATGCTCATAGA
GAATGAATGGTCGAAGGTGGGCGCTGTTCGCCTGAGTCCGATGGTTTCTGCAATCCAAGATGCGAAATTG
GAATGTCATGTGCACACGGTACGGAAAGAAACACTGCCTAGCTACGCGCGCACCATGGACGAGATGTTTT
CCATTTTGTTCAAACAGACGGGCGCAAACGTGGTGCTCACGGATTTTCCTGATCTTGGGGTAAAGTTTCT
GGGCAAACCCGCCCGCTATTG

Protein Information

Protein Name

glycerophosphoryl diester phosphodiesterase

NCBI Protein GI

499184166

Protein Accession

WP_010881706

Protein pI

9.44

Protein Weight

38335.23

Protein Length

356

Protein Note

hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic

Protein Sequence

>WP_010881706.1 glycerophosphodiester phosphodiesterase [Treponema pallidum]
MRGTYCVTLWGGVFAALVAGCASERMIVAYRGAAGYVPEHTFASKVLAFAQGADYLQQDVVLSKDNQLIV
AQSHILDNMTDVAEKFPRRQRADGHFYVIDFTVEELSLLRATNSFYTRGKRHTPVYGQRFPLWKPGFRLH
TFEEELQFIRGLEQTTGKKIGIYSEIKVPWFHHQEGKDIAALTLALLKKYGYQSRSDLVYVQTYDFNELK
RIKRELLPKYEMNVKLIQRVAYTDQRETQEKDSRGKWINYNYNWMFEPGGMQKIAKYADGVGPDWRMLIE
NEWSKVGAVRLSPMVSAIQDAKLECHVHTVRKETLPSYARTMDEMFSILFKQTGANVVLTDFPDLGVKFL
GKPARY

Epitope Information

IEDB Linear Epitope