VIOLIN: Vaccine Investigation and Online Information Network

TmpB

General Information

Protegen ID

857

Sequence Strain (Species/Organism)

Treponema pallidum subsp. pallidum str. Nichols

VO ID

VO_0012400

Taxonomy ID

243276

Molecule Role

Protective antigen

Molecule Role Annotation

Treponema pallidum-susceptible guinea pigs of strain C4D were immunized with recombinant T. pallidum antigen TmpB. Guinea pigs receiving TmpB antigen demonstrated protection expressed by the development of significantly (P less than 0.01) smaller, atypical lesions of significantly (P less than 0.01) shorter duration and devoid of or containing fewer T. pallidum organisms than lesions in the remaining immunized and control animals (Wicher et al., 1991).

Related Vaccines(s)

T. pallidum TmpB Protein Vaccine

References

Wicher et al., 1991: Wicher K, Schouls LM, Wicher V, Van Embden JD, Nakeeb SS. Immunization of guinea pigs with recombinant TmpB antigen induces protection against challenge infection with Treponema pallidum Nichols. Infection and immunity. 1991; 59(12); 4343-4348. [PubMed: 1937794].

Gene Information

Gene Name

TmpB

NCBI Gene ID

2611387

Genbank Accession

AE000520

Locus Tag

TP_RS03880

Gene Starting Position

834955

Gene Ending Position

835932

DNA Sequence

>NC_000919.1:834955-835932 Treponema pallidum subsp. pallidum str. Nichols complete genome
GATGAAGACACGTAATTTCTCGCTCGTATCCGCGTTGTACGTACTGCTGGGTGTTCCTCTGTTTGTGTCT
GCCGCTTCCTACGACGACAATGAATTTTCTCGCAAGAGTCGTGCGTACTCGGAGCTTGCAGAGAAGACAT
ACGATGCGGGAGAGTATGACGTCTCTGCAGAGTACGCCCGGCTCGCTGAGGATTTTGCGCAAAAATCCTC
GGTCTACATCAAGGAAACTATGGCGCGCACCACTGCCGAGGACGCTATGAACGCTGCGCGCACCCGCCAC
GCGTGGGCGAAAAATGAGCGCATCGATCGCGCCTATCCGACCGAGTATTTGCTCGCTAGCGAGGCTATCA
AGACCGGAGGGCTCGCTTTTGACAGCAAGCAGTACGACGTAGCGCTCACGTGGGCGCGTAAGGCGTTGGA
CGCACTCAAAAACGTAAAGCCTGAAAGTCAGTTGCTTGCAAAGGCCGCGAAGGAGGAGGCTGCGCGCAAG
GCCGCCGAGGCACGAAAACTCGAAGAACAAAGAATTGCAGCCCAGAAAGCGCAGGAAGAACGTAAGCGTG
CGGAGGAGGAAGCTGCGCGCAAGGCCGCCGAGGCACGAAAACTCGAAGAACAAAGAATTGCAGCCCAGAA
AGCGCAGGAAGAACGTAAGCGTGCGGAGGAGGAAGCTGCGCGCAAGGCCGCCGAGGAAGCAGCGCGAAAG
GCGGAGGAACTCGAGAAGGGTCGTGTGCTACCTGCGCAATACAAGGTGACTACGTGGTCCATTGACCGGG
AATGTTTCTGGAATATTGCCAAAAACCCCGCCGTTTATGGCAACCCCTTCCTCTGGAAGAAGTTGTATGA
GGCGAACAAGGACAAAATTCCTCAGTCCAAAAACCCCAATTGGGTAGAGCCTGAGACAGTCCTGGTCATC
CCCAGTCTCAAGGGAGAGGAGCGCGAGGGTCTGTATGAGCCCAACGTGAAATACCGTCCTCTGCCGTA

Protein Information

Protein Name

treponemal membrane protein B

NCBI Protein GI

499184674

Protein Accession

WP_010882214

Protein pI

9.18

Protein Weight

35471.38

Protein Length

325

Protein Note

similar to GB:M58562 SP:P19649 PID:155065 percent identity: 100.00; identified by sequence similarity; putative

Protein Sequence

>WP_010882214.1 membrane protein TmpB [Treponema pallidum]
MKTRNFSLVSALYVLLGVPLFVSAASYDDNEFSRKSRAYSELAEKTYDAGEYDVSAEYARLAEDFAQKSS
VYIKETMARTTAEDAMNAARTRHAWAKNERIDRAYPTEYLLASEAIKTGGLAFDSKQYDVALTWARKALD
ALKNVKPESQLLAKAAKEEAARKAAEARKLEEQRIAAQKAQEERKRAEEEAARKAAEARKLEEQRIAAQK
AQEERKRAEEEAARKAAEEAARKAEELEKGRVLPAQYKVTTWSIDRECFWNIAKNPAVYGNPFLWKKLYE
ANKDKIPQSKNPNWVEPETVLVIPSLKGEEREGLYEPNVKYRPLP

Epitope Information

IEDB Linear Epitope