VIOLIN: Vaccine Investigation and Online Information Network

tp92

General Information

Protegen ID

858

Sequence Strain (Species/Organism)

Treponema pallidum subsp. pallidum str. Nichols

VO ID

VO_0012401

Taxonomy ID

243276

Other Database IDs

CDD:227116

Molecule Role

Protective antigen

Molecule Role Annotation

Immunization with recombinant Tp92 partially protected rabbits from subsequent T. pallidum challenge (Cameron et al., 2000).

Related Vaccines(s)

T. pallidum Tp92 Protein Vaccine

References

Cameron et al., 2000: Cameron CE, Lukehart SA, Castro C, Molini B, Godornes C, Van Voorhis WC. Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92. The Journal of infectious diseases. 2000; 181(4); 1401-1413. [PubMed: 10762571].

Gene Information

Gene Name

tp92

Protein Information

Protein Name

putative outer membrane protein

NCBI Protein GI

AAC16524

Protein pI

8.68

Protein Weight

88079.37

Protein Length

944

Protein Note

Outer membrane protein assembly factor BamA [Cell wall/membrane/envelope biogenesis]; COG4775

Protein Sequence

>AAC16524.1 putative outer membrane protein [Treponema pallidum subsp. pallidum str. Nichols]
MLKKASAFLIASCCVMSLAWAQANDNWYEGKPISAISFEGLEYIARGQLDTIFSQYKGQKWTYELYLEIL
QKVYDLEYFSEVSPKAVPTDPEYQYVMLQFTVKERPSVKGIKMVGNSQIRSGDLLSKILLKKGDIYNEVK
MKVDQESLRRHYLDQGYAAVKISCEAKTEAGGVVVQFTIQEGKQTVVSRIQFKGNKAFTESVLKKVLSTQ
EARFLTSGVFKENALEADKAAVHSYYAERGYIDARVEGVAKTVDKKTDASRNLVTLTYTVVEGEQYRYGG
VTIVGNQIFSTEELQAKIRLKRGAIMNMVAFEQGFQALADAYFENGYTSNYLNKEEHRDTAEKTLSFKIT
VVERERSHVEHIIIKGTKNTKDEVILREMLLKPGDVFSKSKFTDSLRNLFNLRYFSSLVPDVRPGSEQDL
VDIILNVEEQSTANVQFGVTFSGVGEAGTFPLSLFCQWEEKNFLGKGNEISVNATLGSEAQSLKLGYVER
WFLGSPLTVGFDFELTHKNLFVYRAGSYGNGLPHPYTSREQWASSPGLAESFRLKYSRFESAIGAHTGYQ
WYPRYAVIRVNGGVDFRVVKNFYDKDNNQPFDLTVKEQLNWTSINSFWTSVSFDGRDFAYDPSSGWFLGQ
RCTFNGLVPFLEKEHSFRSDTKAEFYVTLLNYPVSAVWNLKFVLAFYTGVSVQTYYGRRKSENGKGNGVR
SGALVIDGVLVGRGWSEDAKKNTGDLLLHHWIEFRWPLAHGIVSFDFFFDAAMVYNIESQSPNGSSSASS
SSSSSSSSSRTTSSEGLYKMSYGPGLRFTLPQFPLKLAFANTFTSPGGIPKTKKNWNFVLSFTVNNL

Epitope Information

IEDB Linear Epitope