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FlaA from C. jejuni NCTC 11168

General Information

Protegen ID

Sequence Strain (Species/Organism)

Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

VO ID

VO_0010942

Taxonomy ID

192222

Other Database IDs

BioCyc: CJEJ192222:CJ1339C-MONOMER
EMBL: AL139078
InterPro: IPR001029
InterPro: IPR001492
InterPro: IPR010810
KEGG: cje:Cj1339c
Pfam: PF00669
Pfam: PF00700
Pfam: PF07196
PIR: H81277
PRINTS: PR00207
ProDom: PD000316
UniProt: P56963

Molecule Role

Protective antigen

Related Vaccines(s)

MBP fused on Campylobacter FlaA (MBP-FlaA)

References

Gene Information

Gene Name

FlaA from C. jejuni NCTC 11168

NCBI Gene ID

905631

Genbank Accession

AL111168

Locus Tag

Cj1339c

Gene Starting Position

1269231

Gene Ending Position

1270949

DNA Sequence

>NC_002163.1:1269231-1270949 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 chromosome, complete genome
ACTACTGTAGTAATCTTAAAACATTTTGTTGAACAGAATTAGCCTGTGCCATGGCATAAGAGCCGCTTTG
AGCTAAGATATTTGCTTTAGAGTAGTTTGCACTCTCGGCTGCAAAGTCTACATCACGGATTTGCGATTCT
GCTGCTTTAACGTTTACTTGAGTTACGGTGATGTTGTTTATAGTTGATGTAACTTGATTTTGTACCGAAC
CAATGTCGGCTCTGATTTGATCAAGATTTGTTATAGCTGTTTCAGCTATATCCATCACAGCCATAGCGCC
TTTAAGTGTGGTAACACCTGCTGTTTCATCTTTTACTCCAAAAGCAGTTGTTTTCATAGTTGCAAACTGA
GAAAGTGTTGAACCACTTGAAAAACCTGAGCCTGCAGAAACATTATATACCGTAGAAAGTTGCGAAGCAG
CTGAAATAGCTATAGCGTTTGCAAAACCTGTGGAATAATTTTTACCGCTACCTACAGAATAACCTGAACC
TGAAGAAAATCCACTTCCTGCGCTACTCATATAGGCACTAACAGAAGAATAACCACCTAACACAACTCCT
TTGTTTGCAGAACCAAATCCCATAGCATCAGCGATATTAGCATCAATTTGTCCTTTTGACTCTCTTAAAG
AAACAGAAGCTTGAGAGATAAATTGAGTTGCACCAAAACCTGCAGAAGAAAGATTGCTACCGCTGATTAA
AATATCTTTACCATCATTTTTAACTAAAGACAAGCGGCCATAGTTTTCTTTCATATCAGCATTGATAAAG
GCACCTCCACCTATATTACCATCGATTTTAATCCCTCTACCTTCTCTTGAAGTAAGTAAAAGTTGTCCAT
TAGCATCGATCGAAGCTTCAACTCCAGTGGTATCTTTAACCGAATTGATTGCAGCAACTAAGGCTCCATT
AGCATCACCATCTTTGTAATCTACTTTACCGATTTTTACCCCATTGATAGCAAAAGTATCTGAAGTAGCT
CCTGCTCTAACTGCAGCTATACCTCTAGTTTCTACTGTAAAAGTAGCTCTAACACCTGTTTTATCAGCAT
TTTTATTGATCTCATCTGCTAAAGCTCCAAGTCCTGTTCCAACTGAAGTTGAAATCACAACTTTTTGAAA
CTGAAAATCATCTATACCATTGTAATTTTTAAGAGTAAATTGTACTTCGCCACTAGTTGAAATTCTTCCT
CCTGTTTCAAAGCGTGTTAAACCTATCTTAGAAGATTGAGTTGCTCCTATAGTAGCTTTTACAGTTTGAT
TTGAACTTGCACCGATTTGAAATTCTTGATTGATAAAATTCCCACTTAAAAGTTGTTTACCGTTAAATGA
AGTAGTATTTGCAATATTGTCAAGTTCTTCCATTAAACGGTTGATATCTGCTTGAAGCATGGTTCTTGTT
TTTAAACTTTGTCCATCTTGAGCCGCTTGAGTTGCCTTAGTTTTGATTGTATCTAAGATTTTAAGTTGCT
CATCCATAGCCTTATCAGCAGTTTGTAAGATACCTAAAGCATCATTACCATTAGATATAGCTTGACCTAA
AGTATTAGCTTGAGATCTTAAACTATCTGCTATCGCCATCCCTGAAGCATCATCTGCTGCGGAGTTGATT
CTAAGACCTGAACTAAGTCTGCTTAAAGAAGCATCTAAACTTTTACTATTTAAATCAGCGTTTGCTTTTG
CATTTAAAGCTGCAACATTGGTGTTAATACGAAATCCCA

Protein Information

Protein Name

flagellin A

NCBI Protein GI

218562948

Protein Accession

YP_002344727

Protein pI

5.36

Protein Weight

55763.1

Protein Length

572

Protein Note

flaA, flagellin A, len: 572 aa; 80.7% identity to FLAA_CAMJE flagellin A (575 aa), fasta scores; opt: 2816 z-score: 2717.6 E(): 0, 80.7% identity in 575 aa overlap. 48.3% identity to HP0601. Also similar to Cj1338c (flaA), Cj0720c flaC (24.5% identity in 220 aa overlap), and Cj0887c flaD (20.2% identity in 560 aa overlap). Contains fam match to entry PF00669 Flagellin_N, Bacterial flagellin N-terminus, and Pfam match to entry PF00700 Flagellin_C, Bacterial flagellin C-terminus. The flaA and flaB genes have a GC content of 37% compared to the overall genome GC content of 30.5%

Protein Annotation

FUNCTION: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella (UniProt: P56963)

SUBUNIT: Heteropolymer of flaA and flaB (UniProt: P56963)

SIMILARITY: Belongs to the bacterial flagellin family (UniProt: P56963)

Protein Sequence

>YP_002344727.1 flagellin A [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]
MGFRINTNVAALNAKANADLNSKSLDASLSRLSSGLRINSAADDASGMAIADSLRSQANTLGQAISNGND
ALGILQTADKAMDEQLKILDTIKTKATQAAQDGQSLKTRTMLQADINRLMEELDNIANTTSFNGKQLLSG
NFINQEFQIGASSNQTVKATIGATQSSKIGLTRFETGGRISTSGEVQFTLKNYNGIDDFQFQKVVISTSV
GTGLGALADEINKNADKTGVRATFTVETRGIAAVRAGATSDTFAINGVKIGKVDYKDGDANGALVAAINS
VKDTTGVEASIDANGQLLLTSREGRGIKIDGNIGGGAFINADMKENYGRLSLVKNDGKDILISGSNLSSA
GFGATQFISQASVSLRESKGQIDANIADAMGFGSANKGVVLGGYSSVSAYMSSAGSGFSSGSGYSVGSGK
NYSTGFANAIAISAASQLSTVYNVSAGSGFSSGSTLSQFATMKTTAFGVKDETAGVTTLKGAMAVMDIAE
TAITNLDQIRADIGSVQNQVTSTINNITVTQVNVKAAESQIRDVDFAAESANYSKANILAQSGSYAMAQA
NSVQQNVLRLLQ

Epitope Information

IEDB Linear Epitope