VIOLIN: Vaccine Investigation and Online Information Network

M1
Gene Name	M1
Sequence Strain (Species/Organism)	Influenza A virus (A/chicken/Henan/12/2004(H5N1))
VO ID	VO_0011136
NCBI Protein GI	61698034
Other Database IDs	CDD:278993 CDD:128998
Taxonomy ID	319102
Gene Strand (Orientation)	?
Protein Name	matrix protein 1
Protein pI	9.86
Protein Weight	27345.142
Protein Length	338
Protein Note	Influenza Matrix protein (M1); pfam00598
Protein Sequence	>AAX53515.1 matrix protein 1 [Influenza A virus (A/chicken/Henan/12/2004(H5N1))] MSLLTEVETYVLSIIPSGPLKAEIAQKLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPS ERGLQRRRFVQNALNGNGDPNNMDRAVKLYKKLKREITFHGAKEVALSYSTGALASCMGLIYNRMGTVTT EVAFGLVCATCEQIADSQHRSHRQMATITNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVANQAR QMVQAMRTIGTHPNSSAGLRDNLLENLQAYQKRMGVQMQRFK
Molecule Role	Protective antigen
Molecule Role Annotation	Plasmids carrying the HA, NA, NP, M1, and M2 genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were administered to mice, and the mice were challenged with the homologous virus later. The mice immunized with M1 plasmid survived 25% with five immunizations. The mixture of M1 and NP plasmids protected 95% of the mice against the homologous virus, and 80% of the mice against a challenge with heterologous H1N1 (PR8) virus (Chen et al., 2009).
Related Vaccines(s)	Influenza virus DNA vaccine encoding M1 from Influenza A virus (A/chicken/Henan/12/2004(H5N1))
References