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HA from Influenza A virus (A/Viet Nam/1203/2004(H5N1))

Gene Name HA from Influenza A virus (A/Viet Nam/1203/2004(H5N1))
Sequence Strain (Species/Organism) Influenza A virus (A/Viet Nam/1203/2004(H5N1))
VO ID VO_0011138
NCBI Protein GI 159144921
3D structure: PDB ID 2FK0
Other Database IDs CDD:278910
Taxonomy ID 284218
Gene Strand (Orientation) ?
Protein Name hemagglutinin
Protein pI 6.45
Protein Weight 61425.16
Protein Length 649
Protein Note Haemagglutinin; pfam00509
Protein Sequence 
>ABW90135.1 hemagglutinin [Influenza A virus (A/Viet Nam/1203/2004(H5N1))]
MEKIVLLFAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKKHNGKLCDLDGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSS
HEASLGVSSACPYQGKSSFFRNVVWLINKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNP
TTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSTI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRETRGLFGAIAG
FIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIE
NLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKCDNEC
MESVRNGTYDYPQYSEEARLKREEISGVKLESIGIYQILSIYSTVASSLALAIMVAGLSLWMCSNGSLQC
RICI
Molecule Role Protective antigen
Molecule Role Annotation Researchers evaluated the immunogenicity and efficacy of a panel of flagellin-based hemagglutinin (HA) globular head fusion vaccines in inbred mice. The HA globular head of these vaccines was derived from the A/Vietnam/1203/04 (VN04; H5N1) HA molecule. Results show that replacement of domain D3 of flagellin with the VN04 HA globular head creates a highly effective vaccine that elicits protective HAI titers which protect mice against disease and death in a lethal challenge model with H5 VN virus (Song et al., 2009).
Related Vaccines(s) Avian influenza virus DNA vaccine pH5HA , BV-H5/H7/H9 , dVV-HA5(H5N1) , Flagellin-based HA globular head fusion vaccine using HA protein from Influenza A virus (A/Viet Nam/1203/2004(H5N1))
References