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MSP1 from P. yoelii str. 17XNL
Gene Name	MSP1 from P. yoelii str. 17XNL
Sequence Strain (Species/Organism)	Plasmodium yoelii
VO ID	VO_0011212
NCBI Gene ID	3791597
NCBI Protein GI	82596427
Locus Tag	PY17X_0834400
Genbank Accession	LK934636
Protein Accession	XP_726257
Taxonomy ID	5861
Chromosome No	8
Gene Starting Position	1276003
Gene Ending Position	1281321
Gene Strand (Orientation)	+
Protein pI	5.05
Protein Weight	188296.05
Protein Length	1772
DNA Sequence	>NC_036180.1:1276003-1281321 Plasmodium yoelii genome assembly PY17X01, chromosome : 8 AATGAAGGTGATTGGACTTTTATTTTCTTTCGTTTTTTTTGCTATAAAATGCAAATCTGAAACAATTGAA GTTTATAATGATCTCATTCAAAAGTTAGAAAAATTAGAATCATTGTCAGTGGATGGGTTAGAACTATTTC AAAAAAGTCAAGTAATTATAAATGCAACACAACCAACTGAAACTATTGATCCATTTACAAATCATAACTT TGCACAACAAGTACAAGATTTTGTTACAAAATTTGAAGGATTAGGATTTACAGAACAAACAGAATTAGTC AATTTAATAAAAGCATTAACCCCAAATAGATATGGAGTAAAATATTTAATTGAAAGTAAAGAAGAATTTA ATGGATTAATGCACGCAATAAATTTTTATTATGATGTACTTAGAGATAAATTAAATGATATGTGTGCAAA TAATTATTGTGAAATTCCTGAACATCTTAAAATTAGTGAAGAAGAAACAGAAATGCTTAAAAAAGTAATT TTAGGTTATAGAAAACCAATAGAAAATATTCAAGACGATATTGAAAAGTTAGAAATTTACATAGAAAGAA ATAAAGAAACTGTTGCAGCTTTAAACGCTCTTATTGCTGAAGAAACAAAAAAAATACAACCTGAAGGTAA CGAAGATTGCAATGACGCTAGTTGTGATAGCGATAAATATAATAAAAAAAAACCAATATACCAAGCTATG TACAATGTTATATTTTACAAAAAACAATTAGCTGAAATACAAAAGGTTGTCGAAGTCTTAGAAAAACGAG TTTCTACATTAAAGAAAAATGATGCCATCAAACCATTATGGCAACAAATTGAAGTTCTCAATGCTGCCCC CGTCGTCACTGCCGAAACACAAATAGTTACAGGAGGACAATCTAGTACAGAACCAGGTAGTGGTGGATCA AGTGCATCGGGAACAAGTTCATCAGGACAAGCTAGTGCAGGAACAGGTGTAGAACAAGCTAACACTGTAG CATCTGTTACAGTAACACCTAGTGTAGGACAAAATGGTGAAGCATCAACTAATCCACAAACAGCTCAAGT GCAACCCGTTCCAACTCTTACATTAGAAGAAAAACAGAAAAAAATAGCCGGACTTTATGCTCAAATTAAA GAAATTGCAAAAACTATAAAATTCAACTTAGAAGGAATATTTGTAGATCCAATCGAATTAGAATATTTCA AAAAAGAAAAAAAAAAAGAAAGTTGCAATTTATCAACTTCATCCTGTAAAAAAAATAAAGCATCCGAAAC TATAATACCATTAACTATACGTTATCCAAATGGTATTAGTTACCCATTACCTGAAAATGATGTTTACAAT AAAATTGCCAATAATGCCGCTGAAACAACATATGGTGATTTGACACATCCCGATAATACACCATTAACAG GAGATTTAGCCACAAATGAACAAGCCAGAAAAGATCTAATAAAAGCTATTAAAAAGAAAATAAAAGCAGA AGAAAAAAAATTAGAAACATTAAAAACGAATTATGATAATAAACTTACAGAATTTAATCAACAAAAAACT CCATTCAAAGAAGCAGCTAAAGAATTTTATGAATCAAAATTTAGAAATAAATTGACTTCTGAAATTTTTG AAAAATTCAAAACAAAAAGAGATGAATATATGACCAAGAAAACCGAATTAAACACTTGTGAATATGGAAA TACTAAAGAATTAATTAATAAATTAAATAAACAACTTAATTATTTACAAGATTATTCATTAAGAAAAGAT ATAATTAGTAATGAAATTGAATATTTTTCAAATAAAAAAAAAGAATTACAATATAATATTAATAGATTAG CAGAAGCTGTTCAAGCAAAACAAAATGTATTAGTTGCATCAAAAGATGTACCACTTTCAACACTTGTAGA ATTGCAAATACAAAAATCTTTATTAACAAAACAAATTGAGCAATTAAATAAAACTGAAGTATCTTTAAAC AAAGCTCAATTAAAAGACAAACTATATGTTCCAAAAACATACGGTAATGAAGGAAAACCAGAACCATACT ATTTAATAGCTGTAAAAAAAGAAGTTGACAGACTTGCCCAATTTATTCCAAAAATCGAAAGTATGATTGC TAAAGAGAAGGAAAGAATGGAACAAGGACCTGCAATTACTGGAGAATCTGAAGAAGTACCATCTGGCCCT AGTGCTGAATCATCAACAGATAGATCAACACAATCTTCAACATCCTCATCCTCATCCTCATCTTCAACCC CAGCAGCAGCAGAATCCTCCTCAGCCACATTACCAGAAGCACCCGCACCAGCAGAAGCAGCATCCCCATC AACAGAAGCATCAGAAGAAACAACAATACCCCCTACCACACAAGAAACACAACCATCACAAGCTGCATCA TCCACAACACCTGCAAAACCAGTTATGACAAAATTATATTATCTTGAAAAATTACAAAAATTTTTAGTAT TCTCATATTCATGCCATAAATACGTTTTACTACAAAACTCTACCATAAACAAAGATGCTTTAAGCAAATA TGCTCTTACATCTGAAGAAGATAAAATAAGAACATTAAAAAGATGCAGTGAATTAGATGTATTATTAGCT ATTCAAAATAATATGCCTACTATGTATTCACTTTATGAAAGTATAGTTGATGGTTTACAAAACATTTATA CTGAATTATATGAAAAAGAAATGATGTATCATATATATAAATTAAAAGATGAAAACCCATCTATTAAATC TTTATTGGTAAAAGCTGGCGTCATTGAACCAGAACCAGTAGCAGCACCAACACCAGTAACTCCAGCAGCA ACAGAACAACAACAACAACAAGCAACACCTGATGTACAATCAGATGCACCAGCACCATCAGATGTCTCGC AACAACCAGAAACACCAGTAACATCCACGACACCAGAGGTAACAACCTCAACAGAAGCATCATCATCAGC ACCTGGCGAAGGTACACCATCAGGAGAAGCAGGAGCATCAGGAACAGAAGGAGCAACAGCATCTAACGCA GCCACACCAGCAGGAACATCAGCATCAGGATCAGCAGCATCTAACGCAAGTACAACCTCAGATGTAACAC CCCCAGCAGCAGCGGCAGCAGTACCATCAACATCTACACCAGCACCTGCACAACCACCAGCAGCAAATTC TCAATCAGGAAACCCTGACTCAGGTATTAGATCACGAGCAGAAAGTGAAGAGGATATGCCTGCCGATGAT TTTGAATTAGACAATTTATACAAATCTTACTTACAACAAATTGATGGAAATAATACTGAATTCATAAATT TTATAAAATCTAAAAAAGAATTAATAAAAGCATTGACACCTGAAAAAGTTAATCAATTATATCTTGAAAT CGCTCACTTAAAGGAATTATCAGAACATTATTATGATCGTTATTCTACATATAAATTAAAATTAGAAAGA TTATATAACAAACATGAACAAATTCAACTAACCAATCGACAAATTAGAGATCTTAGTATATTGAAAGCAC GATTATTAAAAAGAAAACAAACTCTTAATGGCGTATTTTATATATTAAATGGTTATGTAAATTTCTTTAA CAAGAGAAGAGAAGCTGAAAAACAATATGTAGATAATGCATTAAAAAATACTGATATGTTATTAAAATAC TACAAAGCTCGTACTAAATATTTTACTTCTGAAGCTGTTCCTTTAAAAACATTATCTAAAGCATCACTTG ACAGAGAATCCAATTATTTGAAAATCGAAAAATTCAGAGCATACAGTCGATTAGAATTAAGATTAAAAAA AAATATTAATTTAGGAAAGGAAAGAATTTCATATGTATCAGGAGGTTTACACCACGTATTTGAAGAATTT AAAGAACTTATAAAAGATAAAGACTATACCGGAAAAAAAAACCCTGATAATGCCCCTGAAGTTACCAATG CATTCGAACAATATAAAGAATTGCTTCCAAAGGGAGTAACAGTTTCAACTCCAGCAGTCGCAGTTACAAC GACACTAGCAGCTGACGCACCAGCAACACCAGAAGGAGCAGTACCAGGAGCAGTACCAGGAGCTGTACCA GGTGCAGTACCAGGAGCAGTACCAGGTGCAGTACCAGGATCAGGAACCGATACACGGGTAGCTGGAAGCA GTGTTGATGATAATGAAGACGATGATATATATCAAATTGCAAGTGGTCAATCCGAAGATGCACCAGAAAA AGATATTCTTTCCGAATTTACAAATGAAAGTTTGTATGTATACACAAAAAGGTTGGGTAGTACATATAAA TCATTAAAGAAACACATGTTAAGAGAATTTTCAACAATTAAAGAAGACATGACAAATGGATTAAATAATA AATCACAAAAAAGAAATGATTTCCTTGAAGTATTAAGCCATGAATTAGATTTATTCAAAGATTTAAGTAC CAACAAATATGTTATTAGAAATCCATATCAATTATTAGATAATGATAAAAAAGACAAACAAATAGTAAAC TTAAAATATGCTACTAAAGGTATAAATGAAGATATAGAAACAACTACTGACGGAATTAAATTCTTTAACA AAATGGTTGAATTATACAACACTCAATTAGCTGCAGTAAAGGAACAAATTGCTACCATAGAAGCTGAAAC TAACGATACCAATAAAGAAGAAAAAAAGAAATATATTCCAATCCTTGAAGATCTTAAAGGATTATATGAA ACCGTAATAGGTCAAGCAGAAGAATATTCAGAAGAATTACAAAATAGACTTGATAATTATAAAAATGAAA AAGCTGAATTTGAAATATTAACAAAAAATTTAGAAAAATACATACAAATTGACGAAAAACTTGACGAATT TGTAGAACATGCAGAAAATAATAAACACATAGCCTCAATAGCTTTAAACAACTTAAATAAATCTGGTTTA GTAGGAGAAGGTGAATCAAAGAAAATATTAGCAAAAATGCTTAACATGGATGGTATGGATTTATTAGGTG TAGACCCTAAACATGTATGTGTTGATACAAGAGATATTCCTAAAAATGCTGGATGTTTTAGAGATGATAA TGGTACTGAAGAATGGAGATGTTTATTAGGTTACAAAAAAGGTGAAGGTAATACATGTGTAGAAAATAAT AATCCTACTTGTGATATCAACAATGGTGGATGTGATCCAACTGCTAGTTGTCAAAATGCGGAAAGTACGG AAAATTCCAAAAAAATTATATGTACATGTAAAGAACCAACCCCTAATGCATATTATGAAGGTGTATTCTG TAGTTCTTCCAGCTTTATGGGATTATCAATTTTATTAATTATCACATTAATTGTATTTAATATATTTTA
Protein Sequence	>XP_726257.1 merozoite surface protein 1 [Plasmodium yoelii] MKVIGLLFSFVFFAIKCKSETIEVYNDLIQKLEKLESLSVDGLELFQKSQVIINATQPTETIDPFTNHNF AQQVQDFVTKFEGLGFTEQTELVNLIKALTPNRYGVKYLIESKEEFNGLMHAINFYYDVLRDKLNDMCAN NYCEIPEHLKISEEETEMLKKVILGYRKPIENIQDDIEKLEIYIERNKETVAALNALIAEETKKIQPEGN EDCNDASCDSDKYNKKKPIYQAMYNVIFYKKQLAEIQKVVEVLEKRVSTLKKNDAIKPLWQQIEVLNAAP VVTAETQIVTGGQSSTEPGSGGSSASGTSSSGQASAGTGVEQANTVASVTVTPSVGQNGEASTNPQTAQV QPVPTLTLEEKQKKIAGLYAQIKEIAKTIKFNLEGIFVDPIELEYFKKEKKKESCNLSTSSCKKNKASET IIPLTIRYPNGISYPLPENDVYNKIANNAAETTYGDLTHPDNTPLTGDLATNEQARKDLIKAIKKKIKAE EKKLETLKTNYDNKLTEFNQQKTPFKEAAKEFYESKFRNKLTSEIFEKFKTKRDEYMTKKTELNTCEYGN TKELINKLNKQLNYLQDYSLRKDIISNEIEYFSNKKKELQYNINRLAEAVQAKQNVLVASKDVPLSTLVE LQIQKSLLTKQIEQLNKTEVSLNKAQLKDKLYVPKTYGNEGKPEPYYLIAVKKEVDRLAQFIPKIESMIA KEKERMEQGPAITGESEEVPSGPSAESSTDRSTQSSTSSSSSSSSTPAAAESSSATLPEAPAPAEAASPS TEASEETTIPPTTQETQPSQAASSTTPAKPVMTKLYYLEKLQKFLVFSYSCHKYVLLQNSTINKDALSKY ALTSEEDKIRTLKRCSELDVLLAIQNNMPTMYSLYESIVDGLQNIYTELYEKEMMYHIYKLKDENPSIKS LLVKAGVIEPEPVAAPTPVTPAATEQQQQQATPDVQSDAPAPSDVSQQPETPVTSTTPEVTTSTEASSSA PGEGTPSGEAGASGTEGATASNAATPAGTSASGSAASNASTTSDVTPPAAAAAVPSTSTPAPAQPPAANS QSGNPDSGIRSRAESEEDMPADDFELDNLYKSYLQQIDGNNTEFINFIKSKKELIKALTPEKVNQLYLEI AHLKELSEHYYDRYSTYKLKLERLYNKHEQIQLTNRQIRDLSILKARLLKRKQTLNGVFYILNGYVNFFN KRREAEKQYVDNALKNTDMLLKYYKARTKYFTSEAVPLKTLSKASLDRESNYLKIEKFRAYSRLELRLKK NINLGKERISYVSGGLHHVFEEFKELIKDKDYTGKKNPDNAPEVTNAFEQYKELLPKGVTVSTPAVAVTT TLAADAPATPEGAVPGAVPGAVPGAVPGAVPGAVPGSGTDTRVAGSSVDDNEDDDIYQIASGQSEDAPEK DILSEFTNESLYVYTKRLGSTYKSLKKHMLREFSTIKEDMTNGLNNKSQKRNDFLEVLSHELDLFKDLST NKYVIRNPYQLLDNDKKDKQIVNLKYATKGINEDIETTTDGIKFFNKMVELYNTQLAAVKEQIATIEAET NDTNKEEKKKYIPILEDLKGLYETVIGQAEEYSEELQNRLDNYKNEKAEFEILTKNLEKYIQIDEKLDEF VEHAENNKHIASIALNNLNKSGLVGEGESKKILAKMLNMDGMDLLGVDPKHVCVDTRDIPKNAGCFRDDN GTEEWRCLLGYKKGEGNTCVENNNPTCDINNGGCDPTASCQNAESTENSKKIICTCKEPTPNAYYEGVFC SSSSFMGLSILLIITLIVFNIF
Molecule Role	Protective antigen
Molecule Role Annotation	Researchers found that the cysteine-rich, carboxyl-terminal region of the MSP-1 protein from the rodent malarial parasite Plasmodium yoelii yoelii can be expressed in a native configuration as a fusion protein in Escherichia coli. This recombinant polypeptide elicits antibodies in mice which recognize the native parasite MSP-1. Most significantly, both inbred and outbred mice immunized with the fusion protein in Ribi adjuvant are partially and in some cases completely protected against challenge infection with an otherwise lethal parasite strain (Daly and Long, 1993).
Related Vaccines(s)	P. yoelii DNA vaccine encoding MSP1 , rBCGMSP1-15
References

MSP1 from P. yoelii str. 17XNL