VIOLIN: Vaccine Investigation and Online Information Network

CS from P. falciparum
Gene Name	CS from P. falciparum
Sequence Strain (Species/Organism)	Plasmodium falciparum 3D7
VO ID	VO_0011218
NCBI Gene ID	814364
NCBI Protein GI	552191
Other Database IDs	CDD:278517
Taxonomy ID	5833
Gene Strand (Orientation)	?
Protein Name	circumsporozoite protein
Protein pI	4.85
Protein Weight	44428.05
Protein Length	502
Protein Note	Thrombospondin type 1 domain; pfam00090
Protein Sequence	>AAA63422.1 circumsporozoite protein, partial [Plasmodium falciparum] MMRKLAILSVSSFLFVEALFQEYQCYGSSSNTRVLNELNYDNAGTNLYNELEMNYYGKQENWYSLKKNSR SLGENDDGNNNNGDNGREGKDEDKRDGNNEDNEKLRKPKHKKLKQPGDGNPDPNANPNVDPNANPNVDPN ANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNAN PNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPN ANPNANPNANPNANPNANPNKNNQGNGQGHNMPNDPNRNVDENANANNAVKNNNNEEPSDKHIEQYLKKI QNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYENDIEKKICKMEKCSSVFNVVNSSIGLIMVLSF LFLN
Molecule Role	Protective antigen
Molecule Role Annotation	We employed a P. berghei parasite line that expresses a heterologous CSP (CS) from P. falciparum in order to assess the role of the CSP in the protection conferred by vaccination with radiation-attenuated P. berghei parasites. Our data demonstrated that sterile immunity could be obtained despite the absence of immune responses specific to the CSP expressed by the parasite used for challenge (Grüner et al., 2007).
Related Vaccines(s)	NYVAC-Pf7 , P. falciparum CS expressed in irradiated P. berghei as Vaccine , Pb(PfCS@UIS4) , RTS,S/AS01
References

CS from P. falciparum