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Eng

Gene Name Eng
Sequence Strain (Species/Organism) Mus musculus
NCBI Gene ID 13805
NCBI Protein GI 226437649
Locus Tag RP23-17P12.4
Genbank Accession AL772271
Protein Accession NP_001139820
Taxonomy ID 10090
Chromosome No 2
Gene Starting Position 32646594
Gene Ending Position 32682668
Gene Strand (Orientation) +
Protein Name transcript variant 2
Protein pI 6.15
Protein Weight 63897.93
Protein Length 652
Protein Note Also known as CD105; AI528660; AI662476; S-endoglin
DNA Sequence
>NC_000068.7:32646594-32682668 Mus musculus strain C57BL/6J chromosome 2, GRCm38.p4 C57BL/6J
GCGCATTTCCTGCCTCTCTGGGCCGGGCTGGATGAGCTGAGCTCCCTGCCCTGACAGTCAGACCCCTGCC
TTCATCTGTGTCCCGTCCCCAGGCCAGGACCGCCGACAGCTGCTGCCCGAAAGAGCCCAGTGACTCTTTC
CCACCACCCAGTCAGCTAGAGACTCCTGCCCTGCTGTGAGTCTCGAGCCCACTTCTCCTGACTTCTCCGC
CGCCACCTCAGAAGGCTGGAGCAGGGACGTGGTCGCTCCGGCCGCCTGCTCCCTTCGGATCCCCGCGCGA
ACCCACGCAGGCCCCGGCGCCCGCCCGCAGCCTTACCTCTGGATACCGGATAAGGCCCAGCGCACAGACT
CCCGGGTGGACAGCATGGACCGTGGCGTGCTCCCTCTGCCCATTACCCTGCTGTTTGTCATCTATAGCTT
TGTACCCACAAGTAAGTGTCCAGCGCCCCTGGGTGGGAACAAGCCCAGGCTAGACCCTGGGTGTTACAGG
TCTTATTCCCATGTCCCAAGCTACTAGCTGATGAAGCCACCCCCAATGTATTAGGAGGTAGAAATGGGAT
CACCAACTATTTTGGTTCAGTGGGAGTAAAATGTTTCATAGGATGCCAAACTTAAGCATTAGACGTCTGG
GGAGAAGTGGGATAAGCTATTTAAGTTAGCGTTGGCACCTTCCTGTTATCCTTCCTGCTGTGTTCAGCTA
TCAAGAAGGCCAGGAGCTACACTGCTATGCATCACTGAGAGTATTCCCTCCCATCTCTGAGCCTTGAGTT
TCCCATTTGAGGAAGTTTAGGAAGGAGGATGCAGAAGTAAATTTAGGCTCTGGGTCCAACTTTGACCTCC
TTGTTTTCTTGTATGAGCCTTGAGGCCTCCGTGCCAGAGGATGCTTAGAGCAAAGACTGGTGATGAGATC
ATTTGTCCGAAGAGTTTCTGTTTCACTAGCTTCAAGTTCTCCCAGCATTCCCGGGCTTTGCCCGCTCCCG
GAACCCCCCAAGGGCACATGCTCTGGCCTTCTCCATTTGCCTTTCTGAGAAGGGTACAGGCTCCATTAGG
GACTCTGTGGATCTTCTCAGCCAGGGTGACTATTGAAAGTGATCTGAGGAGGGTCGGTGAGGAGCCTGGA
CCCCAGTCCTACTCACGAAGGGTCACAGCAGGGCCTGGTCCCCAGCCACCTCCCTGAGGATCCCCGCCTA
CCAACCTGCAGATTCAGGGGCATGTTCAAGGGTTGGGGTGGGCAGCCTGGAAGAAAGAGTATGGGAAATG
ATGGGGCCATCCTGGCACTCAAAGTCCACAATTGATGGGAAATCTGTCATCGCGGGTTAACCGGAAATTG
AGTCTCAGAAACACTGAGTGACTTATCAGGGATTTGACTCAAGGCCTGTGGCCCCTCAGAACCCTTATTC
TGACCACACATGACCCTGCAAGATGGCTGCCCCAATTACCCCATTTCCCAGAAGAGAAAATGAAGGCTCT
AACCTTCCAAATCCACCTACTCCAACAGAGTCTGACCCCAGGCTGGGACAGGATTCCAGGCCCTCTTCCC
CCCGGCTTGGGGAAACCTGCCTTGTAGGATGGGAAGTGGGGTGTCAGTGTCTAGGTGACTGTTCAGAGGA
TAGACCAGTAGACTGTGGTGGTATGCATATTTCCTCAGAGCTGATTTCAGGTCACAAACACTCAGTTCTT
ATTTGGAAATCAGAGTACAGTGGCACACAGCAATTGCCTCTCTCCCCTACAGAGCTGAGAGGTACAGGTG
CCCGCAAGGGTACCTGAGGGTAACGTGGCTAAAAGAATTAGGAAATATGAGTTCTCATTGTGACTAGCTG
GGTGTGTAGTGCCATGGTAGGGCTCTTACCCGCCATATGGAAGGTCCTGAATTTTAAAAAAAATTATACA
CATTTATATTTACAGATGCATATGTATACATATATACATATATACATACATACATACATACATACATACA
TACATAACTTATTTTCTTTCTTGAAACCAGGTTTCACTATGTAGCCCTGACTGGCCAGGGCACAGAATTT
AGCTTTTCAGTGCATAGGGTGAGGGACTGGGCACAAAAAACAGGCCCAGTCTCCCAGAACACAACACAGC
AGAATTTTCTAAATCTGTAACTTGTGTGTAGCGCCTTACCCTCACAACTCAAAGCCAGCCCTAAGCTGGG
TGTGGTGGTACACAGCTGTAATCTCAGCACTTGGAGGTTTGAGGCCATACTGTCCACTCAAGTCCTGGGC
CAGCTTAGATTATGTGGTGAGTTCGAGGCCAGCCTGGGCTACATAGTAAGACTCTATCTAGAAAAGAAAA
GAAAGCAAAGTCAGTCCTTGAGAGTTACCTGTCTACTCCACTGTAAGGATATGTGGCCCACAGGTACCAG
ATTCTACCCAAATGTCTGTCAGCAGGGGTATCATTGAAGAAGTCTTGTCACAGAATGTCATCCAGCAGCT
ACCACAATGGATCCAATCACCATGACACATGTGTATGGGACACATCACACCGTAAAAACCTTACACAGAC
ATCCGTTTCTACTGATAAAACAGCACTGATGCCATTTGCACAGAGAAACTTCTGGAAGGTTGTGCACTCA
GTGTGGCCGCGCATTCGGTGTGGCTGTTTTCCAGTGTGCGATTTTCTCTAGACTCTGGAGAAATCGAAGA
CGTGGATTTGTTTTATTAGTTTATCTGTATGTTTGTTTTGCCTGTATGCATGTCTGTGTGTCCAGGGAGG
TACAGACAGTTGTGAGCCTCCAGGTTGGTGCCAGGAATCGAACCCTGGTCCTCTGGAAGAGCAAGTGCTC
TTAACCACTGAGTCAACTCTCTGGCCCTGGAATTCCTTTAAAGAACATGCGTGTGGAGATTCTTAAAGAA
CAACTTAACCATGTGTCTGTTCCCCAAGGAAAACAGATGAATGAGGGGCTCTGGGGTACAGCTATGTGGC
AAAGCACTTAGTAGGCTAGGAGGACAGAGGGAGGCATGGCGGCCACACCTGTCATACCAGTAGTCAGGGG
GTAGAGGCGGGATCAGAAAGTGGATCACAAGCTCAAGGCCAGACTGGACTAGATGAAGACCTGTCTTGAG
AGAAGTGGGGGGCAGGGGAGCAAGGGAATGGAGTGGGGGAGATAAGAAGAGATGGGGGAAATGAATTTTA
AAATCTTAGGTCCAGGCCGGGTGTGGTGACGCACGCCTTTAATCCCAGCACTCGGGAGGCAGAGGCAGGC
AGATTTCTGAGTTCGAGGCCGGCCTGGTCTACAGAGTGAGTTCCAGGACAGCCAAGGCTACACAGAGAAA
CCCTGTCTCGAAAAAAAAAAAAAGTCTTAGGTCCATGGGCCAACAAAACAGCTTAGCGAATAAAGACCTG
CCGCCAAGGCTAATAACTTGAGTTTGATTCCCCAGAATTTATATAATGGGAAGAGAGAGCCTTATGTTGT
CCTCTGACCTTTGCATGCGGTGGTAGACACACACACACACACACACACACACACACACACACTCACACTC
CTTCTGATTAAGGCTAGCATATCAATGGCAGTGTTTTTTTTTTTCTAGAATATTCCATGTCCAGTCTTCA
GTACTGCAGACAAACACTCCGAGCTCTGTTGGCATCTATAGGCAGCCTCCAGGGCTTCACCAAGTATTCT
GGTCCTTCAGATGAGCATGCGAGAGTCCTGTGGACCCTTCTGAACTGCCGTATTTTTTTCATGGCATTAT
TTGGACTCTATCACAGTTTGTCTGCAGTTCTGGAATATTCTGTTGCATCTGCACGCCACCATTTGAACAG
CAAGTCCCTGCTTGAATATCTAAGTGGTCTCCCTTCTGTTCCAGTTTGGCGCACGCACCCATCCCCGTAT
TTTGGCTTATGGCATTTGGAAGCTCCTGGCACTTGTGGCATGAGCCTGGTGACTGGGGTTAGGCACCTGT
GGCTGAGCAGTGTCTCAAACAGTAGGTGTCATTTGCCTGCGGCTGGGGCGGAGAATGACCTGAAACTTCC
TTACCGATGGCTGGGAATCTTGGATTCAGTGCAGAAGGAGCTGGTGGCAAAGGGCAGAGATTGAATCTAT
GGTTTCGAGGTCACATTCCAGAAGGAAAGAGGGATGAACAAAGAACTGCATTAGTCAGGACAGTAGCTCC
CTGAGACCTATGAGGACATGACCACTCCTGCGACCACTATTGGGACATTCTCTCTCCACACCCAGATTCA
ACTTATTCACATTAAAACCACCTGTAACTCCAGTTCTAGGGAATCCCATGTCCTCTGGCTGCCACAGTCA
CATGCACACATCCATGTAGTGCGCATAAGCTCATGCAGGCATGCACACATACACACGAATAATAAAATAA
ATCTTAAACAGTTAAAAAAAAAAAGATTTTCTCTCACCTCAGCCAGAGAGACAGAGGGACAGAGGACTTG
CTCTGTGTCACATGTGGACCAGTGCTGGGACCTTGGAGGACAGGCCTGCTCCGTGTGCTCTGGGGTCTTC
AGGCAGGTCTGGCAGTTCTCAGTGACAGGCCCTGATTTCCACCCCAGGCTGTCTGCTCTAACCCAGCCTC
CTCTCTGGGCCGTTTGGTGGCTAGGCACAGGAGATTTAGAACTCTGGGGGCCCAGTTCTGGGTTCTACCT
TTTCCTCCAGACCAGGCGTTGGGGCAGCAATTCTGCAAGTTGAGGTGGGGTGCCCATTCCAGAGTAAATT
GGATTTAACATGGATGTGTAAGTAGGGTGCTGGGTATGCCAGTTGGCATTTATGTGGCGCTTACTGTATA
CCAGCACTGGCACTAGTCTAGGCTGTTACCCCTCTGTTGCAGATGAGGAGACTAGGAGATAAGAGCAATT
GCTAAGTAACACAAATTAGAGTGGATAGCCATGTCCCTGAACCTTGGACCAGCCGTTTCCATGAGTTACC
TAAGGGGATGGACAAGCATCTTCCTGTGGTTTGAGATTTGCCCCCGTGCCCCCACCGTCTCAGCCCGGCA
ATGGCCGTCCCTCTTAGACAAAGCTAAACAGCTGCAACCAAGTATGGGTGCACTTGGGAGACTGAGACAA
GAGAATCAAGAATTCTAGATGCGTTCCACATCCATAGTCAGTTTCAGGGCAGCCTGGGCTGTGGGGAATC
CCGTCTCACAAAGCAACCCAGCACTGGGGAGCATTTGGAGGACATGAGTTGGGTTCCCAGAATCCATATC
ACATAGTTCGCAATTGTCTTTAACTCCAGCACTAGGGGATCCAGTGCAGGCACCTGTACACATACACACA
CACACACACACACACACACACACACACATACACACACACACATTAATTGAATCTTAAAAAGAGAAAACCA
GAGGTTGGGAGATGGCTCAGTGGTTAAGAACACTTGTTCCTTCAGAGGACCCAGATTTTGTTCCCATGGT
TATGGCGCACATACATACAAATACATACACACATACATACATATGTACATAATACACATACATATAAAAA
TAGGTACATATATGCATACATACACATGCATGCACACATATACATATATACACACATGCATGCATACACA
CAATACATGCATACATACATGCATGCGTATATACACACATGCATACCTATATACATACATACATACATAT
AAAAGACTCATACAGAGAAAAATAAATGCATGTGAAACAACACAACAAGAACACAGGCCAGGAGTGGTGG
CACACACCTCTAAAGCCATCACTCAGGACAAGGAGATGGCAGGTGAGACTGCCTGAGAGGTCAATGAGGT
CAGCCAGAACTGCAGAGTGAGACCCTGTTGTTTGTTTGTTTGTTTGAGACGGGGTTTCTCTGTGTAGCCC
TGGCTATCCTAGAACTCACTCTGGAGACCAGGCTGGCCTTGAACTCAGAGATCTGCCTGACTCTGTGTCC
TGAGTGCTGGGATCAAAGGTGTGCACCACCGCTCTCTGGCTAAGACCCTGTCATAAATGGGGAGAATGTT
CATCTAGTAAGCATTTGCTATGCAAACACTGAGGACCTGCATTCCGTGCCCAGAGCTCACTCAGTAATGT
TGATGATGATGATGACAATAATAATAATAAATAATAGTAATAAATTTAATAAAAACAACCGGGCGTGGCG
CTGGGCAGAGCAATCCACATGCTAGTGAGTAGGAGCTGGGAAGCTCCCTGGGGGTCACTGGCTATTCAGC
TCAGTCTGCCCAGTGAGCCCCAGGCTAGTGAAAGACTATCTCCATCAGCAAGGAGGTGGTGCTGAGGATC
CTGGGTGTAAATTGCACACATGCACAAGCACGCATACACCCTTACACACTTACCCACACACACATGAGAA
ACAAAACTGCCCAAACCATCAAAACAGATAAAGGCAGTGAAGTACCACCTGACTCTAAGACATCGGGGAG
AGGGGGGGCCCACAGACCTAAGGAAGTACCTCTCCCCTCTCCCCTTCCTCTTTCTCTCCCTTTTGTTTTG
GTGGTGGTCGTCGTGGTTTGGGTTTTGTTGTTTTTGTTGTTTGCTTGTTTGTTTTGGCTTTTTTGAGATA
AGGTTTCTCTGTGCAGCCCTGGTTGTCCTTGAACTCACCCTATAGACCAGGCTGTCCTTGAATTTAGAGA
GATCCATCTGCCTTTGCCTTCCGAGTGCTGAGATTGAAGCTGAGTGCTGTCTCCCCGTTGCTACCACCAG
CAGGAGGCTAGGAGGCACCTGCTTCAAGAAGAGGCCACAGTGGGTTTTTTTGTTTGATTATTTTTGTTTT
TGTGTTTCTTTTTGTTTTTTGAGACAGAGTTTCTTTATGTAGCCCTGGCTGTCCTGGAACTCATTCTGTA
GACCAGGCTGGCCTGGAACTTAGAAATCTGCCTGCCTCTGCCTCCCGAGTGCTGGGACTAAAGGCGTGCG
CCACCACACCCGGCCAACAGTGGTTTTGACAGTTGAGACAAGTTGGTCAGGCTATCAATAAAATGTGGTC
ACTAGGGTCTAGACAGGTGACTCTGCAGTAGCCAGCACTTGCCATTCTTGTAGGGGACCCAGATTTGGTT
CCCAGAGCCCACATGGCAGCTTACAACTGTCCATAGCTCCAGTTCCAGTGGTCCTGATGCCCCTTTTTGC
CCTCTGAGGGGCACTGCCAGCACATGGCACACAAACACACATGCAGGTACACACTTATGCACATGACACT
AAAATAAATACATCTAAGAGGACAGCCGTTGGCCTGAGAAGGGGCAGAGGCAGGCAGGGTGTGTTTGGAG
GAAATGTTCACCTCTGACTGGAAGGACACAGTCCCCACAGCAGTTCCTGAGCCATCTCCATTCATTAGCG
GATGGCTTAGCGCTGTGCATGTGACCAGCTCTCTGAAGGTGACAGAGGGTTTTTACCACCTCAGTGTAGG
GATCATAATTGGGAGGCATAAAAAGGAGCCTGGCCGGCGGCTGCGGCACAGTTAGGATAGGAATTTGTGG
AATGTGTCAACCTCGCCATCCTTTGACCTCACTTTAGACCACAGCTTGTGAATTTGACTCAGTGGCTGTT
GGGAAATTCTGGGAAAGGCATACAAGCGGGGATCTGTGTCTTGCTGGTGGCCTGGCTGGGAGATGGGACA
GCTATGAGGTTGTGATTGGACTCTGAAGAGAGTAGAGGGTGCCTGAGTCGGGTGACTGAAGAAGACTTTG
GTCTGAAAGTGCCCTCCTCGGTGTCGCAGACACTCATAGCACCCATGGGAACCACGGAGATGAGCATCAG
AACTGACTTACAGAAAGCACACGCTGGGGCTAGAACTAGACCCTCAGAGTTCACGACCAGGGCCTGTTGC
TGAAAGTCTGGGTCTCCTAGGGAAATTCTTTAGCCTCCCTAACTACCCATGAGATGGGCATAAGAACCCC
CCCCCCACTGCCCTCCAAAGGCTGCTGTAAGGATCCAAGGAATGTAGTCATACAAAGCTTCCAGACAGGG
ATCGTGATGGGACTTACTGTGTGGTTATTATGCCTACCAATAAGGAGAGCGAGGCCTTTATGACCAGGCC
ATCGGGCCCCAGAGCAACTTGATGACCTCCGGGAGCTATTTGGGGTGGAATGGGGACTGGCTGTGTAAGG
CCTGTGATTGTGGGGTGAAGGAGGAGGAGGAGTAGGAGGATGGTCCAGACGTTTCCTCGGGAGGTCAGGG
TCACCCAGTTCTCCAAAGGTGACTTGTAGGCCCCCAGCGGCCCTTCCTCCAACAGTTCCCTGGAGGCCCC
GGGCAGTTCCCTTGGTACCAGGGGATTGTTTTCAGCTGGCCTGGGCCCGCCTTGGGCTGCTGGAGACAGG
CTCAGGCGTCACACTCCCTCCTGTCTCCCCATTCTCGTCTGTGGGGTGGGGGCAACCAGTATTCGAAAAG
GCCCCAAAATAAATGGGCCTCTTATCTGATCTCCCAGCCTGGCCTGTTATCTGATCATTACATAATGGCC
AGGCCCGCGGCCTCTCCTGCTGGCGCTGGCTGACGGCATGGAGGAGGCGGCCCCAAATGCCAGAGGAACT
GGGGTTCCTGGAAGTCTGGGGAGGGGGGGTCAGGAAAAGTCCGAAGATCTGTAGGCCAGATGGTGGGCCA
TGTGGAGGGAGTAGTCGGAGACCCAGAGGGCAGCCATACGCATGTATGACCTTGATGTGAGTGTCCTGTC
TCTTGAGGTTGCAGCCTCCCCTTCTAGGTAGGAGTGGGGACAGACCAGATGGGAGACTGACAAGAGGAAA
TGGTGCCAACCCTTAGTCTGTTGGGGTGAGGGAAACCTCAAAATTAGTCCTGTCCTCAGCTTCACCCCCA
CCCTTAAATGCAGACAAGAAAACTACAGAAATGAAACTACCACATGCCCTGTCTCACAAATGGCTCCCAA
CAACCTCCAGGGCCGGGTGCTTTCTCTTCCTATTGCCATTGTAGAGATCAGGAAACTAAAGCCCAAAGTC
CTGAAATCATTCCCTCAAACCACACAGCTAGTCAGAACTAGTTGGGCCTGGGATACTGGGCCTGGCTCCC
AGGGACTTGCTTTGAACCAAACTCCCGTATTGCTCAAACACACAGATGTCTCTTGCAAGTTGCTACTGCG
ACTAGAGTAATGGCTGCTAAGTTTGGGCTCTTACAGCAGCAGTAGATACCTGCTCCTATTCTCCTCCCAA
GATGGAGATATCTGAGGGAGGGTGTTGGTGGGGTGTAAGGTAGCCATCTTACCTCCTTCTCTGACCTCAG
TGGCTTTGGGCCCAACAAGCTAGCTACAAAGGTGGGGGAGAAGGCTGGCCAGGCCACAGGCGCCTGGGGT
TCAGGAAGAGCCGGCCTGCCCCCCATCCTCAGCACTGGCGTCAGCTGGACGTGAAGCCTGGCCCTCCTCG
CCCATCTTTGATCTCCAAGAAAACAGGAAGTGAACACGACAAGATGGAGACATAAACTTCCAAACAGCCT
CCCCTTCTCTGTCCCTCCTCCACAGCCCCCCTTCCCCTCAGCACATTCCTTAGGACGAGGTGTAGGGGCC
TCATTTCCTCTTCCTCCTCTGCTGGGTCAGGGTGAAATTCCATTCCTCTCCCTTGGGACCCGTGTTTCCG
GGCCGCCCTGCAGCCGACTGTGAGGCCTGCTCTACATCACCGCCTTTAACCTGGGCTGCTCCCCCTGAGG
CAGGAAATTCCCTCCTCAGAAACGGCCTCTCAGGAATGGACACCTTGAGGTCTGAAGAGGGAAAACCGTT
TTTCCTCCTCAACGCCACCCGGTACACACACTCCTTCCTTTGGATTGAACTGGCCTTAAGACTTGGGGTC
CACCATGGGCCCTACCCCTTGGGTCACCCTGCCAGCAATAGATAGCTGGGCACGGTGGCACTTGCCTTTA
ATCCCAGCACTGGGGAGGCAGAGACAGGCCATCTCTGTGAGTTCAAGGCCAGCCTGGTCTACAGAATGAG
TTCTAGGCCAACTGAGATTACACAGTGAGATCTTGTCTCAAAAATACAAAAAGAACAAAAAACAAACAAA
TACTTCTGAAAATTAGCTAAAATTTCATTTCAGGCAAACTGTTTTTGCAATATAAGTATATAATTATATA
TTTAAAATTATACCTTGAAAAAGGATTCCCGTTTATCTGAAATTCAGACTTATTGGTACCCTGGCTCTTA
CCTTCCTTCCAACATTATACCTACTAACACTATGATCCTAGGAGAGACTTTCTCCGGCTGTGTCTCAGTT
TGCCCATCTGTGGAGAGTATGAAATGATATCTACCATGTAAGGTAGCTATGAAGATGTCATACGCCTTGA
GCTCTGGGCTCATACGTGTACCTGGGAAATGTTCAGAAAGTGAACGTGGTTGTATCCAGGCGTGGTGGGG
AATCCTAGCATTAGGGAGGCAGAGGCTGGAAGACCTGAAGGTCAAAACCATCCCTGGCTACATTGAAGCC
AGCCTGGGCTACCACAGCTCTGCCTCCAAATAACAACAACAACAACAACAACAATAACACAACAATAATT
CTTTTTTTTTTTTTTTTTTTTTTTGGTTTTTCGAGACAGGGTTTTTCTGTAGCCCTGGCTGTCCTGGAAC
TCACTCTGTAGACCAGGCTGGCCTCGAACTCAGAAATCCGCCTGCCTCTGCCTCCCAAGTGCTGGGATTA
AAGGCGTGCACCACCACGCCCGGCTAGCAACAATAATTTTTTTTAAGATTTATTTATTATTACATCTAAG
CACACTGTAGCTGTCTTCAGACACAGGTGTTAGATCTCACTAAGGATGGTTGTGAGCCACCATGTGGTTG
CTGGGATTTGAACTCATGACCTTTGAAAGAACAGTCAGTAATCTTACCCACTGAGCCATCTCTCCAGCCC
CGCAACAATAATTCTTAAAGAGACTAGGAATACAATTAGTACTCTTCCCTCCCAGTGCCAGGGACTGCCT
TGCCCACACTAGACAAACATTCCTGCCCCATCCTCCTCTGACCTAACCTGCTTTCCCACTATGCTTTCCC
AGCAGGTCTCGCAGAAAGAGTCGGCTGTGATCTACAGCCTGTGGACCCCACAAGGGGTGAGGTGACGTTT
ACCACCAGCCAGGTCTCCGAGGGCTGTGTAGCTCAGGCTGCCAATGCTGTGCGTGAAGTCCACGTTCTCT
TCCTGGATTTTCCCGGAGTGAGTACCTCAGGCAGGTTTGGCGGGGTCCCTTAAGAATCGGAGTAGACTGG
GTGAAGGGTGACTTCTTACAGCTTTACTAGCACCTCAGCCATGGGGCTGATGGGGCAAGTCCTGGGAGGG
CCCTTAAGAGGTAGAAGGTATGATTTTCTGGAACACATCACAAGAGCCAGCTGGAGGGCCGGTGACATGG
CTCATGGGTAAGGGAGCTTGTGGCTCACCGGGTGAGGGCACTTACCACCATACAGGATGACGTGAGTTCA
AGTCTCTGAACCTACATAAGCAAAGAACATCTTCCTCAAGTTGTTCTCTGACTCTCGTGAGCGCACACAC
ACACACTTTTTTTTTCAAGACAGAGTTTTTCTGTGTAGCCCTGGCTGTCTTGAAACTCACTCTGTAGACC
AGGCTGTCCTTGAACTCACAGAGATCCACCTGCCTCTGCCTCCAGAGTGCTGGGATTAAAGGCATACGCC
ACCACACCTGGCAAAAAACAAAAAAGGAAAGGACCCAGATAGAAAAGAGCTAGTTAAATGTGTTAGTGTG
AACTAGGGAAGCTTGTGTCTAGATGCAGCTAGTGACAGGGCTCTCAGAGCTTTTCAGAGGACATGACTCC
ACTCTAAGCTGGGCTTTGGAGAAAGGGTTGAGTTCTAGTCTACCTCACCTCAAACATCTGCGAGTCCACT
AGGCATCCTTTGAGATCCAAACCCCGCAAGCCAGCCTCAAGTCTGATCTCCAGCGGCTTGCCTCCAGTTT
GTCTAGATGTAGAGCAGCCATAGCCCATTTGTCAAATGCTTGCTGCATGCTAGGTGTTAGGCTGCAGCCT
ACCGTCACCTAGGAAGCCACCAGCTTTGTCTGGTTGATTAGTTCTTTTTTTGAACTAGGATTCATGTAGC
CCAGGCTGGCCTCGGTTTTGCTATACAGCTAAGGATGACTCTAATCCTCCTATCTCCAAAGTTCTGGGAT
TATAGGTACGTGTACCACATCAGACTTACATGACCCTGGGCTTCAGGGTCAGAGTCTCATGCCTGCCAGG
CAAACATTCTACCAACTGAGCTACATCCCTAGCCATGGATACAGACATGGCGGGGGCTCATTAGGGTCCC
GTATTATTCTCATTTCTTGGAGGAGGAAACTGAGTCCACCCTTGAGAAGTAAAACATGAACTGAAAGTCA
GAGGACAGACACACCAGAATCCTAGGGACCTCAGAGCCAAGGTCAGGTTCACTGGCCTGCCTGGGCTGCA
GCCCACGCCTAGCTGATGTAGACTAAGGCCACAAGAATGAATTAGGAGCATGGGATGAATTTGTAGCCAA
CCTGCCCCTAAAACTGTTGAGTTACTTTGCATTTTGTGTAGTGATAAGAAGGTGCCCAGACCACCAATAT
CGGGGGGCCCTGCCTGCCACAAGGACTGTGGGCTTTGATAACCCCCAAGGTACAGATAGTACCAAATACA
TTTTATTTGGCTTTCATAAGCATAGCAATTGTTTTTCAAGTCAGTAATGATATGGAAAAATAAGAAGCTT
TCCTGTAAGTTCATTTTGTTCTCAGGTTTAGGCCCTTGCACCTCTTCTGGGTGATCCTGGGGTCTCCTGA
CAGCAAAGCCAGGCAGAGGAAGATCCCAGCCAGATGGCCAGGTCTCTGGGCCACAGGTGTGTAGACAGTT
CCAGCCAGGACACAGGAGACTGGTGTTGTGGCAGGGTACTTCAGCTGCTAAGCTTAGGCAGGGCTTCCTG
GAGGACGTGACAACACAGAGGAGCTGGACCCTCCCAAGTGTGGGCACAGCCGGGGAGAGGATGTAAGCAG
AGGGAGGGAGCTGCCCGCTCAGACTCTGACAGGACCTTGAGGTTCACCTAGGAGCAGAACTGGAGAAATG
GCAGTTATTGAGAACTTGGTTTTTAGTCTATGAGCAATGGTGACCACTGAAGGAGTTTTAGGGCTGTGTT
GTGTGTGGGGTGCCACAGTAACTCATGGCATAGTCCAAGGATTCCAGCATCTGTGACAAGAGAATTTCCT
TGTAGCCCTCTGCCCCTTCCAGAGAACTTTATAGATCATGGGACATTTTTATTTTTACTTTTTTTGGTGT
TTTGGAGACATGGTTTCTCTGTGTAGCCCTGGCTGTCCGGGAACTCACAGAAATCCACCTGCCTCTGCCT
CCCAAGTGCTAGGATTAAAGGCTTAGGGAGCTGCTGCCACCTCTCTTCCCAACCGACCTTGTGACATCTA
ACCCATCAGGCCAGGCCTCCAGCCCTAGGACTATGAAGGATATGCATTTTGAAGGGGTAGGAAAGAGAGC
TGGGGTCCCAGGGTTCAGTCCTGGACCTGTCATTGGCCTGCACCTTGCATAGAGCTTGAGCTGCTGAAGG
GGCACCTCTTATATTTTTCTTGGGTTCAGAGGCTCGCTCAAGAATTATGAAACTATGGAACCTGGTTCAG
GACCTGGTCTATTCCAAATAATTAATATATTCCATAAATGAATGCATATTTGTGTAATAAATGCATTCAA
ATGGGACCACGATACAGTGTTTAGGAGCACGGCTTTTAGTCAGGCATTGTAGTGTGAGACTGAGCTCCCA
GTTACTCAGGAGCCTGAGGCAGGAGGATGGCTTGTAACAGTACACGTTTTAGGTCATCCTGGCCAACGTA
GTGAGAGTTTGCTCAGAAAACAAACCAAGGAAAGAGGACGTAGCGTCTGGAGCCAGTCAGTCCTCATCTG
AACCTCAGCTAATCTCACGGCCACATCGCTTTGTTGGCAAAGCTGTCTGAACCCTGGTCTTCCCACGGGA
AACATGGAGACAATGATAATCTTTCCTACCTCACAGGTTACTGTGAGACTCCAGGATAAAGAAAGCAGAA
CACAGAACACAGAACCTGCCCACAGTGAAAGCTCTAGTTTGGCTGTTATAAATTTTGTCATTATTACTAT
GTCTCCTGGACTCCATTTTTCATCTGTAAATACTTGGACATGACCCAGTTTCCAAACATCTTCCATTTAG
TTTATTACTCTTTAAACCTCACACTAGTTCGAACTCAATGGAGAAGAGGCAGAGACTGAAGATCCATTTT
CAGGCAGGCTAATGGAGGTGGAGGCTCGTGGAGTTCCTGGCCTATCTGTCCGTGATCCTGGTCAGTCTTG
GTGCTTTGACCACCAAGAGCCTGTGACCTGCTGAGCACTGACTTCCCTTCCTGGGAGTCTCCAAGAACGA
GATCCATGCCACTCCCTCACTACCAACTCTACAAGGGTGCTTGCTGTTGTCAAGGGTAGAGATAGGAAGT
AAAGCTGAGCCAATCACAGGCCAAGAATTGATATGAGTGAGTGAGTGAGCGAGTGAGTGATGGAGTTAGC
CATCTTGGGAAGGATGAGAGGCTGTGGGTGACAGGGAGATACTCACCCGTTGTAGAGAGGAAGGGATTTG
GGGGCTGCACATGGAGCTCAGTTGTTAGGGTGCTTGTCCATCATGAGGCCATGGGTTTGATCACCAACAT
CTCATAAACAGCGAGTAGCTCAGCACCCAAGAGGCAGATGCAGGAGCATTAGAAGTCCAGGTTAGGCGAG
AGCGATCGCTCAGCAGCAAAGAACACTTGCTGCCCTTTCAGAAACCCCATGTTCTTTTCCCAGCACCCAC
ATCAGGCAGTTCACACCCGCCTGTAACTCCAGCTCCAGAGGCCCCAACACCCTCTTCTGGCCTCTATGGG
CACCCACATACAGACACATACACATAATTAAGAATAATTGTTTTTAAGTTCAAGGTAGCATGGCACGTGT
AAAGGCCTAAAGGCCAATTGCGTGGGTGAACAGGCCTAGTGGGGGAGGCACTGCCTCTCCTGACCTTTGG
CCTCCTTTGTCAGTCCCTGGCACAGAAAGATGGCTTTCTCGTCCATCCCCACATGGCTTTATAACCATCA
GATTTCCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGCAGATGAGTGGTGG
CAGCCAAGAACCCCAGGAAAGTGACATTTGAAGTGTCTGTCTGTCTGTCTGTCTGTGTGAGTGTGTGTGT
CTGTGTGTTGAGGAAGTCTGTAGACAAACTAGGGGCTGCTGGGCAGGGGTTATCTCACTGGGTCCCCAAA
GGACAGGCCGGAGCCTGGATTCCGGGAGGGGCCTAGGGTCACATCCTGACCTTCAAGACAGGAACAGGCC
TGGTGCCTCAGCGATTCCCATCAGCTGACTACCCTGTTCTGCTGTCCCAGACCTAGGCAGCCAAGCTTGT
TTGGCTGCTGATTTGCTCCCCCCCCCACCTCCCCCTGCCCTCGGCCTGGGCAAACTCAGGGAGCTCCTTC
CTCAAGATAGGAGCCAGCCAGGCTCTGACTCACGCCTAGCCAGAGGGGGCATGGAGACAGCGAGCCAGGG
GAACCTCCACTGATTGTCCTCAGCTATCATGGGAGACAGTGAGGGGCTGGGAAGGCAGGGTGGCTCTGAG
AAGTGGTATCACACTGAACAGCCTCTCTGTCACCCATTTCCGGCGACACCTCTGCTCCACAGTGGGAAAC
TTGCAGCACTGAAGGGATGTACCTAGAATCCTTCTCTTACACCGCAGAGCCTGCTCAGGGTGCCCAGAAC
CCCTGAGTGTCTTGCTCAGTTGTGTCTGAGCCTATTGTGCAGGCTGCAGGGGAGTGGCTTTTATTATTGT
CCCCAGAAAAGAACCCTGCCCGGCTGATGTGAGTTCTTCTCTACCTGAAGAGTGGCAGAGCTGGCTCTGG
GGGAGGCAGCCCAGAGGATTCTGGGCTGGGTTTCTCCCATCTGGACGCATGAGCACACTCACTTTGCTCT
CAGAAGCTGAAGAGACCAAGGGGCCCTGGAGAGGGAGCTTCCTTTGTGTCTTTGTGCCTTGCAGGTGATG
AGCAGGGAAGGGAACCGGTGTAGCAGGGTCAGGTGGCTGCACAGGGGCTCTCATCATCTCCCCGGCTTCA
GCACTGAGTCACCCTGAGAGGACATATTTATTGGATAGACAGACAGATAGGTAGTAGACGATCAAAAAAG
GGGGGGTCCATAAAGCCTGGAGAAAATCAAATGAAGTCTTTTAAGTCCTGAAAGTAAACAGCTGTGAATC
AAGAACACTGTACTCGCAAAACTATCTTCCAACACTGAAGAATAAAAAAAGGCATTTTGATGCTGGGCAG
TGGTGGCGCATGCCTTTAATCCCAGCACTTGGGAGGCAGAGGCAGGAGGATTTCTGAGTTCGAGGCTAGC
CTGGTCCTACAGAGTGAGTTCCAGGACAGCCAGGACTACACAGAGAAACCCTGTCTCCGAAAAAAAAAAA
AAAAGAAAGAAAGAAAGGTAGGTATTTTGAGACAGACACAAATGAAGGTAAGACATGATTAGTAAGGACA
GCAGGCAGTCCTCGGTGGGATACTTTACAGGAAAGAACCTGGCAACTCAGCAAGCCCTAAACCTTGTATG
AAAGCAAGAAAAGAAATACCAATAACTTCACAAAGCAGAACAAACCTAGCACATTTAAAGGAAGAAGCAA
AACCCCCCCTTACAATTCTCTTACAAATAAATTGTTTTGGCTTATAGTTTAGTGCATCACAGTTAAATAG
GACACTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTCTCTTTCTCTCTCTCTCT
CTCATTTGTTGAGTCTTGACTTGTGTCCTAAGGCTGGTCTTGGAGGAGAAGTTTCTGAGAAAATCTGCTG
AGGAAGACATGTGCGTTCCCTTCCCCTTTGGGTGGAATGTTCTGTCCGTATGTTAAGTCCAGTTCATCCA
CACTGTTCTTGGCTCCCGAGTTTCTTTGCTAGCTTTTAGTTTGGAAGACTTGCTGAGTAGGAGAGTGAAG
GATTGAAGTCTCCCGGTGTTACTGTATCAGGACCTGGTTGGTCTTTGTATCTTGGAGTGTTTGTTTTATG
CAATTGGAGGCTCCAATGTTTGGTGCATAGAAGTTAGAATTGTTGCATCGTCTTGAATTGTTTCTTTTAT
TAATCTATGCCTGGCATAGTGGCCCGCATCTTTAATCCCAGTACTCAGGAAGCAGACATAGGCCAATCTC
TGAGTACAAGGCCAGCCTGGTCTACAATAGTTCCAGGACAAACAGAGCTTCATAGTTAGACCCTGTCTCA
AAAATAAACAGGCAAACAACACCAAAAGGTAGAGTCCTTTTTATCTTCTTTAACTAGTTTTGGTTTGAAG
TTGACTTTGTTTAGCATAAGAATAAATTTCCATTGGCTTGGCAGTTTGTTTTCCATGCTTGGAGATGAAG
TTTTGGGGTATCTTTGTTGACTAAGTATGCTTCTCGGAGAGCGCATATAGCTTGTTCTTGTTATTTATCC
AGCCCGTTAGTCTGTGTCATTGAACTTGCAGGAGTTCTTGTGCCTCCTGAGGGCCAGACTCACAGGCATG
TGCCACTGTATGTAGCTCAAACACATTGTGTTTAAATATATTTAAACATTTTAAAGGTTTCAGACTAGAC
ATGGTGGTATATCTCTTCAGTCCCAGCAATTGGGAAACAGAAACTTGAGGCCAGCTATGTCTACATAGTG
AGTTCTAGGCCAGCCATAGTTACCCAGTAAGACCTGGTTTCAAAAAAGAAAAAAAAAAATCAGACTTGGG
CTTGGAGAGATGGGGCAGCCCTCAAGAGCACATTCTGGTTTTGTAAGAATTCCAGTTTGATTCCTAGCAC
CCATGTTAGGTGGCTGTGAGCCGGGGACCTGACTCCCTATTCTGGCACATTCGTGCACACATACACATAC
ACACTATACACACACCGCATACAGACACACTATATACACCACACACATACACATACACACACTACACCCA
CCATAAACACACACATACACACACTACACACACCACACACACACACACACACACACACACACACCATACA
CACTCACATACACACATACTGAAAACATTTCATTCAGAAATCAGTCATGATGGCACATACCTGTGACCCC
AATATCCAAAGACTGAAGATGTTGAGTTTAAGGCCAAACTTGCACACAATGAGATTCTATCTCAAAATGG
GGTGGTGGCACATCCCTTTAGGGCTACATAGAGAAACCCTGTCTCAAAAACAATTATTATTATTTTATTA
AGTTAAAATATTGGGGTCAACAGCAGTGTCACATTCCTGCTTCCCAGTTCTATGGGAAGTTGAAGCAGGA
GAATCACTTGAGTGCAGGGCAAGGTGCCATCTCTTAAAATAAAAATAAAGAATTTTATCTGCATTAGTAG
AATCTATCAGTGGACCCAGAGGGGCTGAGCTAGGCATCGTAAAACCAGCTATGAGGCCGGATCCCTGCAT
CTTCACACGTACGTGAGCAGGTAGGTTGTCTAGCTCCTGCTCCAGATCAGGCCCAGAGAGGAAGACAGAA
CGTCCAGACTCACAGAGCCACGTTTAATTCAGGTCTGTCTGGCTCTGAACTCTTTGCCTGCGACACTCTT
CCTGTGTGCACCATCACAGTCTGCTGAGGCCGACTTGGGCCTCCTCTGGGCTGGCCCTGGGAGGGTGGGG
GCTGCAGGCAGACCCAAGGCTCCACTCCTAGAAGAATTGCTGGAAACGGCTTTCTATAAGTGGCTACTAA
TACTCAGGGCCTCTTCACCGAAATCCCCCTTTCCCGACACCAACCACTGGGCTAACAATGGCATCTAAGG
GACAGCTGGTACCAAAATAGCAACTGGTCTCCCACCCACCCACTCAGGGAAGGAGTCACACAGGCCCGTG
CTGGCAGGCCTGGGGTCAAGGAACTGGCACATACGTCATCCTTGCTGGGCCTCCAGATGCCCAGGAGCCC
ATGCTGAAGACGGGCAGCCCCTCAGGGGACGAAAGAGGGAAATCAGCATGCATGCGTGCAAATGGCTGGC
GTAGTGACTCAGGGTGGAGGGGAAGGGAAGTGTTTACTGTGGAAACCCTGGCTGAGTGATTCTGGTAACT
GGTCGTCATCAGTTAGGCCTGGGAGCACAGAGCCCCCAGAAGCTCTGCTTTCCAGTCTCCCCGTGTCTCA
CACTGCTCACTCTGGGGCCTCAGTTTCTCTCAGCCCCTTCCTCTGTACATAAGACCCTGGTGACAATGGA
GTGGGAATTTGCCTTATGAATTCGGGAAGAATTGCTGAAACTTGTCACAAGTGTCCTGAAGCCACAGCCT
CTTGACCCGTGGTACAGCCCCCAACACCCCCACCCCCCACCCCACCCCCTGCGGCATGACCGTGCCCTGC
CCTCCGATTTCTTTTCTTCACTTCCTCTATCCAGGGCCCCTCCTGGTCTTGGTTTCCAACCCTTTCCTGC
CCCCATTTCACAGATGAGTAAAGGGAGGCACCAAGGGATCAGAGCTACGGTAAAGTAGCTGCAGGGTTCA
TGTCCAGGGCACTTTCCAAATCCTCCTCATAGTTCCAGCTGTGTCAACCTGTGGTGTCCTCCCAGAGTGA
CATTGCCTCATCTCCCTGTCTGCGCGAGTCTCCTGGCATAGTCTGCCAGATAACTGACTCCATCTATTTG
CTCTCTGGGTGGAGCTGGTAGCAGTCTGTTTGGGGGGACAGAGAAAAGGATCTACTACTGGGCAGCCAAG
TGCCGTACGCTCCACTCAAGTGCTGGTCCCGGACTGTGGGCTCCACACTCTCTTTGGGTGACTTCCATTC
TAGAGCCTGGGAGCTGAGAAATCCCTGTGCCTGCTTTAGTCAGCCTGCACTTGCTGTGCGCTCAGCACAG
AGCATAGCATGAATTCCATTGGACCATAACACATTACAGGCACACAATTGCTTTACTGAGGTAAAACCCA
CTGATTTGAAGTGTGCAGTCTAACTGAAATGAGAAGTTTTAGGTTCAGGGAGAGACTCTGTCTAAGAAAA
TATAGACACATAGCTGTGTAACCAACCTGTGGTGTTCAAGCTACTGGTACACAGAAATCAATCAGGGTGA
TATGTTGCATGTGAATATATTTTCGGAGACAGAGTCTTTTTTTTTTTGGATATATGTAGCTATCCCAGAA
CTCACTATGTAGATCAGGCTATCCTTGAACGTACAGAGATTTACCTGCCTCTGCCTCCCAAGTGATTGGG
TCAAAGTTATATACCACTTCAGCCATCTTAAAATGTATAATTTTTAAGATTAATAAAACAAGATACTTAT
GAAATTAAAATGTAAACCCATTAGTAAACATTATGTGGGCTGGAGAGACAGCTGAATGGTAGGATGTTTG
TTAAGCATGCACAAGACTGGGTTTGCTCCATAACACTGTAAATTATTATTATTATTATTATTATTATTAT
TATTATTATTATTGGTGGTAGTATTTCCACATGTCTGAAATGCATTTTTTCATTATACTATAAGTTACTG
TGAGGATACTTATTTAAGAATAATAACCTAGGGGGCTGGAGAGATGGCTCAGCGGTTAAGAGCACTGACT
GCTCTTCCAGAGGTCCTGAGTTCAATTCCCAGCAATCACATGGTGGCTCACAGCCTTCTGTAATGGGATC
CGATGCCCTCTTCTGGTGTGTCTGAACAGAGAGACAGTAAGAAACCCTGCCTCAAAAACTAAAATGGAAA
ATGGCAGAGAAAAATATCCAGACTGGATCTCTGGCCTCTACGTGTGCACACACAGGCAAGTGAGTCCGTG
CGTACGCACATGCACTACACACACTACTAAGATAAAGGGGCTGGAGTCTTCTGGCCTCCATGGGGTCCAG
GCATGCACATAATACACATACATACACATACACACACACACACACACACACACACACACACACACACACA
CACACACGTTTAAGTTTTTGTTTTTGTTTTTTCGAGACAGGGTTTCTCTGTGTAGCCCTGGCTGTCCTGA
ACTCACTTTGTAGACCAGGCTGGCCTCGAACTCAGAAATCCGCCTGTCTCTGCCTCCCAAGTGCTGGAAT
TAAAGGCATGCGCCACCACGCCTGGCTTACGTTTAATTTTTAAAAGAATTAAAATAAAGATCACCTAAAG
GGATCGAGCACCATCAGGACAAAACCACTGGGCACACGTTGAAAACAAAGCGAGACCGTTTGCTCTTCTC
CTCTGTGGCTGTAAAGAGTAACCCCGAACACAAAGAGTGATTAAGAGGGTCGTTTACCGAGTAGCGGAAA
TATTTCTGAGCAGATTTTTCCAGGGACTGAAACGCTTGTCTCTGGCTCTGTGACATCAGTCAGGGAAACA
ACAGTGAGTCGATTAGAAGCCAGACCCTAAAACTTTCCACTGATGTCTCTGTGCTAAGCCCATGCTCTGC
TTTCTGACAGAGGACAGAGCTTGCTTGCAGTCCGCTATCGGACTTCATGCTGCTGGCAGGAACTGCCAGA
GACCGTGTCTGGGAGGATTTCCACTTGTCTTTGTTCTCTGAGACACCACAAGGTTTCTGAGGCACCGATC
TGGGCCAGGCGCCTTTGTCTCCTGCTCATTCCCCCTCCCTCACCATCTCATGGGCCCAGAAAGCTCTCGG
AATAGCTTTGATCTGGCCATCTTTTCTTTTCTTCTTAGTCTTCTTGACAGAGCTGGACATTGCCAGCCTT
CCGTGTGATCATGGGGCAAGCAACCTCACTTCTGTGACTCGGTTTCCTAATTTGTGAACGTTTTACCAGT
ACCCACTTCTTAGGTTGTTTCCATGGAGCTCATAGGTAAATGTGGGTGGAACCAGGTCATGCGCGTGTGA
TCTGCCACTGAGCCGCCATGCCAGCTCTAGGAACAATTGTGAATGGTTGGAGTGAGCTGGCATCAGAGTG
GCCTCCCAGAGACAACTAGAAAAGGGGAGAGGACAGTGAGAGAAGGCTCGCTGCTTCCATGCATAGCTTA
ACCTTCAGACATTTACAGGCCCAGGTTACAGCAGACACTCAGTGGAAATCATCCTGACTGGATGTGCTGG
CATGTGCCTGACATTCCAGCACTGAACTAGGTAGGAAGAGTCAAGAGTTCGAGGCCAGCCTGGGCACAAA
GCAAGAACCTATGAGGAGAAGGAAGTGGAAAAGGAAAGGAAAGGAAAGGAAAAATGAATCTCGCAATCCT
GAATGTTACGTGAAGCACAGATCTGACTTAGTTTGTCCTCTTTTTTGCTTGGTTGGGACCAAGCTCATTC
ATTCATGCATGCATGCATGCCTTCTTTCCTTTTTTAAAAAAAATTATTTATTTATTTTATGTATATGAGT
ACACTGTCCCTCTCTTCAGACACACCTGAAGAGGGCACTGGATCCCATACAGATGGTTGTGAGCCATCAC
GTGGTTGCTGGGAATTGAATTCAGGACCTTTGGAAGAGCAGTCAGTGCTCTTAACCACTGAGCCATCTCT
CCAGCCCCCAGCCTCCTTTCCTTATTAATTTACTTATCTTTTGTTTAATTTGTACTTATTTACTTAGCGT
GTTTGTGCATGCATGGGTGCATGCGTGTGTGTGCCTGTGCATGTGCGTGTGGGCACATGTCACAGTTCTG
GTGCAGAGCTCAGTGGATAACCTGCAGGAGTTGGGACTCTCCTTCCACCAGGTGGGTTCTGGGAATTGAA
CTCAGGACCTCAGGCTTGGCAGTCATGCTTGCTGAACCAGTCCCTCTTATGTTTCCAAGGGGTGTGAGGG
ATAGGTGCTACTTTGCAGATGGGTAACTGGTGAGAGGGTGGGTAGGTCAAGCCACAGAGGGACAGAGGAA
TAACCATCAACCATAAAGCATCGCTGCCCCACTGGCTGCAAACCTGACTGATATATCTACGTCCATGGTT
CTTCTCCAGATGCTGTCACATCTGGAGCTGACTCTTCAGGCATCCAAGCAAAATGGCACGGAGACCCAGG
AGGTGTTCCTGGTCCTCGTTTCGAACAAAAATGTCTTCGTGAAGTTCCAGGCCCCGGAAATCCCATTGCA
CTTGGCCTACGTGAGTGTGTGACCCTTAACTCCAGGCAGGCTGTGGGAAATCTCTGCCTGGTGTCCCTCT
CTGTGAGCAACATGGCACACCAGAAAGGCAGAGGCAGATAGGAACAGGACCAGAAGGTGCCAGAGGAGGC
AGAGGTGGGCAGTAGAGGTGAAGATGGCTCACAGATGGACACATAGACCAGCATGGTGGAGACACCATGG
AAAATCCCCTCCCAAGTTCAAGGGTCCGGCCTCCCTTCCCAGAGTGCTCTTCTCCTTCTCATTGAGAGGG
GAAGTCAGGTCCCAGAGATCTTCCCATGGTGCCTCTCCAACCAGTCCCTTCCCCACTTGCTACCCAGGGT
TGAGGAGCTGCCAGGGTCCTGAATGACACTTGGAATGCAAGCTCTGGCTGTAGGGTTGCAGCTGCAGCCT
AGCCTGGTTGCATCTTTTTACTTGCTCTGAACACACACAGTGACAGCCCTGAATCATCTGTGTGCAGATC
ACCACTCAGAGGCCAGAGGCCGTAAACCAGGGGCCTGATAGTCACGGCTGTAACCCTGTTTTACAGGGGT
TAATGCCTGCAGAGTAGGCAGTGTGCGCTATTATATCTCTTCTGACTGTCATGCAGTCCTCCTTAATATC
TAATCTGAAGCCCTCCTGCTGCTGCTGCTGCTACCTCAGCTCAAAGTAGCTTGGAGTCAATAGTCCTAGC
TGCTTCCTCTAGATCACCTCCTCCAGGAAGTCCTCTTCATTTCCTTCCTTAGCCCAACAGACCCCAGAGG
AGCCTAAGGGAGGTAGTAAGGTTTGGGATCTCTCCAGACTCCCCGTCCCCAGAATAAATTTAATCTAATT
TTATGTATAGGTGTTTTGTCTGCATGTGCGTCTGTACCATATGTGAGCCTTGGGCCTGAGGGGGCCAGAA
AAATGTTGCATTCCCTAGGGCTTTAGTTACAGATGGCTGTGAGCCACCATGTGGGTGCTGGGAATTGAAC
CTGGGTTCTCATGAGAGAAGAGTCAGGGCTCCTAACCACTGAGCCATCTTTCCAGACCCTCTTTTTGCTT
TTCATGATAGGGTTTCTCTGTGTAGGCCTGGGTGTCCCAGAACTTGCTATGTAGTTCAGGCTGGCCTCGA
ACTCACAGAGTTCTGCCTGCGTCTGTCACTCAGGTGCTGGGATTAAAAGCACGAGCCACCACTACCTGGC
TCCAGCCTTGGTTTTTGTTATTTATTAAATAATGTCCTCTATCTTCTATTACTTCAACTAATGATGTCTC
TCTAGTTTCTTAATGGTGAGCTCCCAGAGTTGGCAGAACCCCATCTGTCTTCATTCATTTACTCATTCAT
TTTTTTCTCACACCTTTCTTCCTTTCCCCTTCCACTGTCCCCTTCCCCGTGCATTGAGAGTACCTAATAT
GTGGCAGGTCTCAAGGTGCAGCTGGCGTATCAGATCCCCAATGAACAAAGGCTCAGAGCCTTCAATGAGT
CAAGTGCTATGGGCACCAAGATTTCCCTCCCATACCCTCAGAGTGCAGACAGTTACAGACAGTAGCTACA
TTGGTGCCATTATATATGGTTTGAATGAGTGCCTCATGGTGAGGGTAAAGCAAGGACAGACAGACGAACA
AATGTGTGTCTCTGTACAGCCATCACATGCAGGAGGGAGATGGAGCAGATCTGGCTATGCTAGAAGAGGT
ACCGGGGGCTCTGGGCTGACTGACGACTTCCGAGCCTTGTCATTTGAGGTCCCGGCCTCTTTGCTGCCAG
ATTGGTAGGAAGTGACCCAGCACTCTGTGTCTCCACAGGACTCCAGCCTGGTCATCTTCCAAGGACAGCC
AAGAGTCAACATCACAGTGCTACCATCCCTTACCTCCAGGAAACAGATCCTCGACTGGGCAGCCACCAAG
GGCGCCATCACCTCGATAGCAGCACTGGATGACCCCCAAAGCATCGTCCTCCAGTTGGGCCAAGGTCAGC
TCCCTCAGTTGCTTCTGAGTTCAGGTTCACTTGCAGAGGAGACTGAGCAAACTCCTGATATGGGCACTAC
CAGCTTGTGGTGGCATGTGATTTGCCCACAGTCAAACGTGACTGGCTGGTGCCCTTTGCAGTTAGCGACT
GCTTCTGCATCATATAGCAGATGAGAAATGCCAGATTTTTTACTTGGGATGTGGCTTGGTTGGTAGAGCC
TGTGCGTAGTGTTAAGCCCTAAAGCCCTAGAACCCTAGAGCATGGTGGCATGGACCTGTGGTGCCAGCAC
TCAGAGGGCAGAGGCAGGAGAATCGGGAGTTCAAGGTCATCCTCTGCCACATAGCAAGTTCAAGGCTTCC
CTGGAGCTTGCTGGTCAGCCAGTCTAGCCAAGTCTTCGAGCCAGGTTCAGTGAGACACTGTGTCTCAAAA
AAATAATATGGAAAAAAAACCAAAAAAACAAAAAAATAATATGGAAAGCAATTAAGGAAGATACTTGACC
TGTGCTGGCGTGCTGGGTGGGGGTGGGGGAATGCACTCTTGACACATGCCATGGGCTCACTTGCTATGTT
AACCCTGTGCTGACACAGGCGGAAACAAAGGCCGGCTACTCAGTGGTGAGTCATCCTCAGCCCTGTTAAG
CTTTGTCCTGAATGTCCTCATCAATGCCTTGTCTGGAAGTGGGGTAGGACCCTCTGATATATCTGTCTCC
ACAGACCCAAAGGCACCATTCTTGTGCTTGCCAGAAGCTCACAAGGACATGGGCGCCACACTTGAATGGC
AACCACGAGCCCAGACCCCAGTCCAAAGCTGTCGCTTGGAAGGTGTGTCTGGCCACAAGGAGGCCTACAT
CCTGAGGATCCTGCCAGGTTCTGAGGCCGGGTAAGCTAGCCTTTGTGTGTATTACCCAATCAGATCCTAG
TCTCCAAATGCATTACCCAATCAGATCCCAGCCTCCAGGCGTATTAACTTTCCTATTGCTGAGATAAAAC
ACCATGACCAAGGCAATGTGTAGAAGAGTTTATTTTGGGCTTGCAATTCCAGAGCATCAGTTCTGCATCA
GCATGAGTTCACGACAGCAGAGTGAAGGTTGCAGGCAGCAGGCAGCTGGAGCAGCAGCTAAGAGCTCACA
TCTTGAACCACACAGATAGGAGGCAGAGAGCTCACCAAAGCCTACCCCTTGTGTTCTACACCCTCCAGGA
AGGCCCACTTCCCTAAGCCTTCCCAGACTGGGATCAAGTATTCAGATGCTCATACAGATGATGTCTCATC
CAAACCAGCACACCAGGTCTGTCCCCATACTAAAGCCACAACCCATCTGCCCGCCCGCTGCAGGCCCCGG
ACGGTGACCGTAATGATGGAACTGAGTTGCACATCTGGGGACGCCATTCTCATCCTGCATGGTCCTCCAT
ATGTCTCCTGGTTCATCGACATCAACCACAGCATGCAGATCTTGGTGAGCCTTGTACTCCCACCCCAGCC
GAGACCTTACACACACACCTTCCCCAGCTTTCTACCTTCATCTAAGTTGTTAAAGTAAAGGCCACTTCCA
GGAAGCTTGTCTTGATGGGCCAGGGAATCCGTTAACCTAGCCTGGTAGGCCAAGGAAGACTCCTGGAGAT
ACAAACTCTGAGCTGGGTCAGAGGTCAAAGGGGAAATGGAGAAGGTGAGGGGAAGGGACGGCAAGGCACA
GGCGAAGGGCAGGGGTCTCCGTAGGTAAGATGCCAGCTCTCTTTTTCTGCCTTCAGACCACAGGTGAATA
CTCCGTCAAGATCTTTCCAGGAAGCAAGGTCAAAGGCGTGGAGCTCCCAGACACACCCCAAGGCCTGATA
GCGGAGGCCCGCAAGCTCAATGCCAGCATTGTCACCTCCTTTGTAGAGCTCCCTCTGGTCAGCAATGTCT
CCCTGAGGGCCTCCAGCTGCGGTGAGCCACAGCCCTGTGCCCCTGTCCCAGACCTGTTGCTCCTCCTCCC
TTTCCATTACTTTGTGCCTCTCTGTTCTTTGAGCTTGGCTGGTTTCTCTGAGCCTCACTGGCCTCATCTG
CCACCCGTAGTGCACACCCAGTGACGGTCTACTCCACCCACTCCATAGGTGGTGTGTTCCAGACCACCCC
TGCACCCGTTGTGACCACACCTCCCAAGGACACATGCAGCCCCGTGCTACTCATGTCCCTGATCCAGCCA
AAGTGTGGCAATCAGGTCATGACTCTGGCACTCAATAAAAAACACGTGCAGGTAAGTAAAGCCCCGCCCC
TCCACCTTGAGATGGCATGGACAGCTGGTCCCTTGCCAAGAATGTCAGGGGCCCAGCCCAGGCAGTAAGA
GCAAGTCACATCCCTGTGCAAGCCTCGGTTTTCTCACTTGTGAAATGCAGTTTGAACAGAGCACAGAGCC
GTGCACTGGTATTCTCAGAACCTGGGAGGCTGAGCGAGGAGGATGGTGAATTTCAGGTGGACTAGGCTAC
ATAGAAGGTATAAAATAGAGTCATCCTCAACTACATAGGGAGTTTGAGGACAGCCTAGGCTACATGAGCC
CCAATCTCAAAACACAAGTAATAATCATACCAACATTAGGTAGTCATTATTAATCTTTGTTTATTTGTTT
TCTTTTTAAGACAGGGTTTCTCTGTGTAGCTCTGGCTGTCTTAGAACTCACTCTGTAGACCAGGCTGGCC
TTGAAATCATAGAAATCTGCCTGTCTCTGCCTTCTGGGTGCTGGGATCAAAGCTGTGTGCCACCACTGCC
TGGCTTAGTCATTATTATTAATCTTAATGGTGGTTGAGCCAGGTGGTCACAGAAATTTGTATTATGTGGC
CTTTGCATGATTGATAAATCCAAAAGACACTGTGCAGGGCTGGGGTGGTGCCCAGGGAATAACGTGTTCG
CCGTGGAGTAATGTGTTTGTTTGCCGTGGAGTAACGTGCTCGCCGTGCAAGCAAGAGGGCCTGAGTTTGG
ATTCCCAGCACTAGGAGGCAGAGAAAAGGAAGCCCTGGGGTCTCTCTATCCAGGCCAGCCAATCCGTGAG
GTCCAGGTTCAGTAGGAGACCCTCCCTGTCTTGCCAGGTGTGGTAGCTTGTGGGTCCCCACCCCCCTTGG
TTTTCTTTGGAGACAGGGTTTCTCTGTGTAGTCCTGGCTGTCCTGGGACTCACTCTGTAGACCAGGCTGG
CCTTGAACTCAGATATCTGCCCGCCTCTGCCTCCTAAGTGTGGGATCAAAGGTGTGCACCACCACGCCCA
GCTAGCTTGTGCTTTTAATCCCAGCACTTGGTCGGCAGAGGCAGGCAGACCCCTGTAAATTCAAAGGCCA
GCCTGGTCTACAGAGTGAGTTCCAGGCCAGCTAAGGCTATGTAGTGAGACCCTGGAGAGAAAGAGAGACA
GAGACAGAGAGACACAGAGAGAGACAGAGAGAGACACAGAGACAGAAATCAATGGAATGACCCAGTGGTG
AAACATTTGCACACAGCCTGCTTACCTGAGTTCAAGCCCCAGAACCCACAGGAAGGTGGAAAGAAGAACA
GCTCCATTAAGCCGTGCTCTGACCTTCACCTGTGTACCCTGCCCAGGGCACACACTAGATAACCATAATA
GGTTAGTTTTAAAAGCAAGGTGCTTTGCACTGCATGGTATCTGCACTCAGCAGTTCTTTCCTGTTGGGTG
TTCAAAAGACAGTGTGATAGAAACTCACTATCTGGCATCGTTGGTTTCTTGGCTTTGTGCGTGTTAAACC
TGGTATTTCTAATGATACAGTTTAAAAAAAAAAAAAAAAAGCAAGGTGCAGTAGTAAAAGATGCCCGATG
CCTGATAGCAAACTCTGTGCTCCACACATGAGCACCTATGTGGGGGTGTACATATGGTAGATAGGCCACA
CACACACAGAGTATATAAACTGCACACACAACACACATAGAGAGTATATAAGCTGCGCGCGCACACACAC
ATACACACAGGGTATATAAACTTCACACACATACACACACACACACACACAAAGTATATAAACTGCACAC
ACAACACACACAGGGAGTATATAAACTGCACACACATACACACACACACACATGCACGCAGAGAGAGAGG
CAGAGAGAGGTACTAATACCTTCACTATGTATTCCTTATTGGACTAGAGCCTTAAACTCACAGAGATCCC
CCTGCCTCTGCCTCCCGGGTGCTGGGATTCAAGGCGTGCTCCACCCTGCCCTACACAGAATGGAGGAAGT
CTTCATCTTCCCTTCTGAACTTGTGACCCTCCTGACCTCCCCTCCTGGATGCTGGATTATATTATATTAT
ATTATATTATATACAATGCTGGATTATATTATATATTATATTGTGCATGCGGCACTGTGCCATTCTCAAT
TTGCTTTTGAGCAAACAGAACATATGTACGCGCCCACTCCGATTTGTTTCACTCATTCCTCCCCTCCCCC
ACCCACCTCCCAGTGCTGGGGGTGGAACCCACCTGGAGTCCCAAAAAAGTCTCGTCTGTTCTGTACCTAC
TCAGTAGAGCTGTGTCCCCACCCCCCTACAATAACTTGCTTTTATTTGGGGAGTCTGAATCTGGCTATGA
ACCATATAGTGTGGAATTTGCTATATGGACCAGGCTGGTCTTAAACTCAGTAGAGATCTGGCTGCCTCTG
TCTCCTAGGGGATGGGAATTAAAGGTACACACCACCATTCCTAACTTTTAACTTATAAGAAAAAACCCAA
ATAAAAAAAATTAAATATTTTTTAATGTATATGGGTGTTTTTCCTGCATCAAAGTCTATTCACCACACTT
GCCCACAGAGGCCAGAAGAGGCCATTGGATCCCTGGACCCAGAGTTATAGACGGTTGTGAGATGCCATGT
GTGAGTTGGGGACTGAGCCCAGGTTCTATATAAGAGCAGTCAGTGCTCTTAGGCACTGAACAGTCTCTCT
AGATTCTTATTTTAACTTTTGAGCTTTTTGTTGTTGTTGTTTAATTTTTTTTGAGACAGGGTTTTTTTTT
GTTTGGTTTTTGTTTTTTTGAGACAGGGTTTCTCTGTATAGCCCTGGCTGTCCTGAAACTCACTTTGTAG
ACCAGACTGGCCTTGAACTCACAGAGATCTGCCTGCCTCTGCTTCCCAAGTGCTTTGATTAGAGGTGTGT
GCTGCTACCACCCAACTTAAAAAAAAATTTTTTTTTAAATGTTAGATAGGAGCTGGGCATGGTGGCGCAC
CCCTTTAATCCCAGCATTCGGGAGGCAGAGGCAGGTGGATTTCTGAGTTCTAAGCCAGCCTGGTCTACAA
AGTGAGTTCCAGGACAGCCAGGGCTATACAGAGAAACCCTGTCTCGAAAACCCAAAAAAAAAAAAAAAAA
AAGAAAAGAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAAAAATTTAGAAAAAGTTAGATAGGGTGG
AGAAATGGCTGAGCAGCTAAAAGCTGTTCAGAAGACCTAAGTTTGATTCCTAGCACCTATACGGTGGCTC
ACAACCATCTGTAACTCTAGTTCCACGGGGTCTAATGCCATCTGCTGGCCTCTGAAGGCACTACATGTAT
GTGGTGCATACACACACTTAGGCAAAACAACACACACACACACACACACACACACACACACACTCACGTG
CCCTGGGTTCAGTTCCCAGCAATGGAGAAAATAAGAAGACATTCTAGTTGCCCATCCACTACTGAATAAT
TTTTTCCTGGTTTTTCTGAAGTCTCTGTCAGAGCTTTGATGTCCCCTTGGAAAGGTTTCAATAAGGATTC
ATTTTACTTATTTTTAAACTATGTGTAGGGTGGGGGGGGGGTATGTGCACGTGGCTACAAGTGTCTACAA
GGCCAGTAGTCATACTCCCGAGCTGGAGTTACAATCGGTTGTGAGCATTCTGACATGGGTTGGGTGCCGG
GAACTGAACTCGAGTCCTCTGCAAGAATGGCCGGGGCTCTTAACCGCTGAGCTATCTCTCCAGCCCCCAT
GAGCGGTACTTACAGTGTTTCAGTAGTGACAGCGAGGCCTGAGGGAATGCCGGGCCTCCTGATGATTCAG
CCCTTCTCCCCTGGGTCAGACTCTCCAGTGCACCATCACAGGCCTGACTTTCTGGGACTCCAGCTGCCAG
GCTGAAGACACTGACGACCATCTTGTCCTGAGTAGCGCCTACTCCAGCTGCGGCATGAAAGTGACAGCCC
ATGTGGTCAGCAATGAGGTAAGGCCTGGGAGTAGGAAGGTGTCATGTCCAGCAGAGTCGGTGTCCCCTCA
GACACCTCACTGATCCCGGGGCTGAGGGACATTTTGGGGAGCGGGAAGCAGCAGTGAGTAGGAGCCAAAA
CATAGATGCTGCTAGCTTGGCCCTTCCCACCCATCAGTCAGGCCTGGGAGACAGGATATCCTCTGGGGTC
TTTCTGGCTCTGACCGGCTTCTTGGCTCTGTCTTTGCAGGTGATCATCAGTTTCCCGTCAGGCTCACCAC
CACTTCGGGTGAGATGGACGGTCCTACAAGGCTCTCCAACTGGTGCAGGGTGGCCTGCTGGGGTGGGGCC
ACTTTCTGGCCTACCAGGGAGCAGACCTCAGGAAACTCAGGCCTGAACCCTGACAAGGCCCGTGTTTCCA
GTGTGCCTCAGTCTCCCCTTCCATACAATGGGAGCAGTGCTGCTGAGGGTTAAGCTTTCGGCCTCTTAAA
TCCAGGCAACCAGCTCACAGTGGCTGTGTCACCTTGGGCAAATCATTTAACTCTCCCCGGGGCTCAATGG
TCATTGGCTATAAACTGTGGCATAAAAAAAGTCCCCACCCCATAGGGGTCTTTAAGGAGCAGTACCGAGA
GGTGTGAAGTTTCTCTCCACTAGCCCAATGCCAAGTGATTTCTTCATAAATGTGAGAACTATGAGTTTAT
TATTTAAAAGGTGAGGATGGTGGTCAGGCGATTCCTGCTGTCACTCCGTTCAGACCGCCCGCCTCCTCGT
GTCCTCCCACAGAAAAAGGTACAGTGCATCGACATGGACAGCCTCTCCTTCCAGCTGGGCCTCTACCTCA
GCCCGCACTTCCTCCAGGCATCCAACACCATCGAACTAGGCCAGCAGGCCTTCGTACAGGTACTGTGCAC
CCCACCTAACTATCTCCTTGAGTCTTCTATGGGCCTTTCTTCCCAACGTTGCTAAAGAGAAGATCGGATG
CCACCTTCCAGAGGAAGGAGAAGGCCAGCCCGGGTGTGTGTGTGGAAGGCACAGAGAGAAAACGACTTGC
ACTTTGGAATGTCACTCTGTCCTGCCTGCTTGTTCCTGGAGCCTGTGGGGCTCCTTCTTGTCTTTTATTC
AGAGGGGTCCCTTTCTAACTGACGTCAAGAGGGCGAGGGCGTCAGTGAAGAGCCAAGGATACCTGCGTGT
ATCTCCTCCGTCTGTCTGTCTGTGCAGGTGAGCGTGTCTCCATTGACCTCTGAGGTCACAGTCCAGCTAG
ATAGCTGCCATCTGGACTTGGGGCCCGAAGGGGACATGGTGGAACTCATCCAGAGCCGAACAGCCAAGGG
CAGCTGTGTGACCTTGCTGTCTCCAAGCCCTGAAGGTGACCCACGCTTCAGCTTCCTCCTCCGGGTCTAC
ATGGTGCCCACACCCACCGCTGGCACCCTCAGTTGCAACTTAGCTCTGCGCCCTAGCACCTTGTCCCAGG
TGAGTGGACATGGCTTGAGACTAGTTTCACTGAAGCTGTGATGTCAGTATATACACACACCTGCAACTAT
CCACCTACACGTTTATCCTCTACATATTTTAACATCCATCCATCACCCATCTGCCCACATATCAGGATCC
CAACCATTTATCCACATACCCATCAATCTACCTACCTATTCATGGACTCCACCTACGCACCCACCAGAAG
CCTAGCCATTCATTCATAGACCTACCCACATACCCAGCTATTTACTCACCCACCCAAACAACCCACATAC
CCAACCATCCACCTACCCACACACACAGCATTTACTGCCTGTCAATCCATGTACCTATCCACCCATCCAT
CATCTATCCACCAATCTACCTACCTATCCACACGCACACTCCTGCATCCACCTACCTCCCCTCTCCCTAC
CAGCCGCTCACCCATCACCCACCACTTGCCCTTCTATCTACTCATCCACAAGCATCCATTATTCTCAATA
CTTTCACTAGCTCACCTAGTTACTCACTTACTCTAGAATCCCACCCACCCACTAACCACCCACCTACCCA
CCCACATGGCGATCACCAATGTGACTGATCTCAGGAAACTTGACACTCTGCCCTGCTGGTATCACACGTT
GCCCTCAGTCCTGACACACTCACAAGAACACTCCAGGTGTCTGCACACAGATTTCTTTCTTTTTTTTTTT
CCATTTTTTATTAGGTATTTAGCTCATTTACATTTCCAATGCTATATCAAAAGTCCCCCATACTCACCCA
CCCCCATGCACACAGATTTCTAGGACTCAAAACCTCCTGAAGCTGGGCCCCCACACAGACAGCTATACCT
GTCTTCCAGGCCCTGAGCCTCCAAGCATCTGGGCTGACCTGGCTTGTGGCTCACGGCTTGCACAGGCTAA
CAGATGCTGGGCTCCTACTGGAGACCATTTACAGTAGCCGCAGGCTACCCTGCTGCTCTCGCACACCATG
TGCCTCCCTAGGATTTGCCTGCAGCCTCCCAGCCTGAAAATAGCGGACAAATGACTCAGCCAAGGGCTGG
GATGGCAGCAAGGGAGAGCTGCAGACAGGGAGAACCGCATGCTGCCAGCTGAAGGCTGGGTCACTTACCA
GACTCCTCCCTCCTCAGGAAGTCTACAAGACAGTCTCCATGCGCCTGAACATCGTCAGCCCTGACCTGTC
TGGTGAGCAGAGAACAGGGCTGGGAATGGAGCCCAGATATGGGGCCCTTGGGAGGAGAGGAGGGTTTCTC
AGGCCCAGCAGCCCGAGGAGCTCACAGTAAGATGCCAGGTGCCATAGACAGCCCTCCACTCTCAGACCCC
TCCTGGGCCTCATCTCTGTCCCGTTAGTCACTGGTTGCCATGATGGAGGACTTAACCTCCTGGACAGAAC
ATAAGGCACCTTAGCTATGGTATAAGACCCCACATTCCTTGACATCTCAAGGGTAGAGGAAGCCCCTTGA
GCCTAACACCCTCTGGTCTCTATTGTTCCCCTGGGCCCAGGCACTACCAGGCAAGAGAGTCCTGTTGCTA
GGGGCAGATACAAGCGGTGTAGCCTAGGATGGGCCTAGCCTAGGGCTGAGAATGCAGGGCTCCTAAACTC
CCTGCACAGACAGTAAGTCTAAGGAGACTAAGGGCCCAGAACTATGTAGAAACAGGAGGGAAGCCTGCAG
TAACCCGAGCAGCACTGGTTTTAAAAAGATGCTCTGGCCCATTTGAATCTGGTGTAAGGTGCAGAGGTGG
GGCGGCTGGTTGGAGAGGTCACACAGCATGGCAGAGCAGGCCCCTTCATTCTTTGCACCCACAACACCAT
CCATAAAGGAATTACCTGCTGGGCTTTGGAGACAGGAGGGTGGCCCAAAGAGCCTGGCCGGCTGGGCCCT
CGGCTTAGTACCGAACTAGATGAAGAGACCTCTGTCCAGAGAAGTCGAGTCACTGACCCAGTTGAATCTA
GCTAATACCCGTGACCAAGGCCAGCATGAGAGGGTAGGGACAGGCCTGAGGCCACAACACACTGACTATC
TTGGCCCTCCTTTGTCACACAGGTAAAGGCCTTGTCCTGCCCTCTGTACTGGGTATCACCTTTGGTGCCT
TCCTGATTGGGGCCCTGCTCACAGCTGCACTCTGGTACATCTATTCTCACACACGTGAGTATCCCAAGCC
TCCACCCCATTCCCACAGCAAGCGCTCAGGGCCCGTCCACACCACCCCGGGGCACACCCAGTGGAGCCTC
TGAAGAAGCGGGGAGTCCTGGCTGGGGCCCTGACCTTCACCCACGCCCCTCAGGTGGCCCCAGCAAGCGG
GAGCCCGTGGTGGCAGTGGCTGCCCCGGCCTCCTCTGAGAGCAGCAGTACCAACCACAGCATCGGGAGCA
CCCAGAGCACCCCCTGCTCCACCAGCAGCATGGCGTAGTGCCCAGCCTGGAGCCTCGGGGAGCCCCCCAG
CCAGCCCTTGCCCTGCAGGAGAGACCGAGCAGCCACAAGCTGGAAACCACCGGCCATGAACTTGTCCCAG
GAACCAAACACCTCCCCTGCACCTGTTCATTCCTCCCAGTGGAGACTTCAGATTGGAATACCTTGGGATC
TCCTCACCCCACTTTACAGAACTGCCCAATCCAGGGGCTCTGGGATATGGCTGCCCGGGATTACAGAAAG
ACACGGCACTGCCGTGCACACCCATGCTGCTTAGAAGCCTAAGCCTCTGCCTTCAAGCTGGATCCTGTGC
AGGGTGGGCAGGCAAGAACTCAGACATGCCCAGCCTAGCCCAGGGCGGCCTGCATCTGGCCCCAGAAGCC
TCCTCACCTGGACTGGCACAACTTCGGTTGGGGAAACAGAAGCTGAGGGAGCTTAGATGGGGTGGGGGAT
CCAAGCCCCTCCCAGCCCACCCATTGGCCAGGCAGCAGGGGGGAGTGGCCAGGCGGCTGGTTGTGGGCCA
AGTCCTGCATATTCACTAATAAATCAGACATGAAACCAGTGCCCCTCTGGGTTGTATGGGAGAAGAGGAA
GATGGGCAATTATGTCACAGAACAAGGGTGCACACCCCTTTGGTCGGCATGGTAGCAGACAGCCAGAGCC
CATGTGTGGAGGAAGTCAGTTCTCTCTGCTGCTTGCTCATTTGGTAGCCCAACCTTGGGTCAGAGGGGAC
AGAAACCAAACACTAAAAAGCCCTGTCTACAGTCTCTGGGACACAGCTACCCCTATAAAGTTCTGGGTTC
TAATCCTGTACATGACTCTTGTGGGCAATGAGCCTGTGGACAGCTCCAAAGTCAGCCACCCTCCCTCATC
TGTAAGATGGGCGTCCAACTTGAATGCATTGTCACCAAGGAGGCTTGCGATGCAGTGCCTTGGTGTGTGA
CACACAGTGTGCCAGTCTTTCATGACATGAGAGGACTAATCCTAGGCCATACTGTGTTAAACTCCAACCC
CCAAATGTCTGATGAGGGAGCTAGGAGAATAGGAGTCAATCAAAAGTTTTGTCATTTATTTACAAAAAAT
AAAAAATAAAAGGGTTTAAAAGCTT

Protein Sequence
>NP_001139820.1 endoglin isoform 3 precursor [Mus musculus]
MDRGVLPLPITLLFVIYSFVPTSLAERVGCDLQPVDPTRGEVTFTTSQVSEGCVAQAANAVREVHVLFLD
FPGMLSHLELTLQASKQNGTETQEVFLVLVSNKNVFVKFQAPEIPLHLAYDSSLVIFQGQPRVNITVLPS
LTSRKQILDWAATKGAITSIAALDDPQSIVLQLGQDPKAPFLCLPEAHKDMGATLEWQPRAQTPVQSCRL
EGVSGHKEAYILRILPGSEAGPRTVTVMMELSCTSGDAILILHGPPYVSWFIDINHSMQILTTGEYSVKI
FPGSKVKGVELPDTPQGLIAEARKLNASIVTSFVELPLVSNVSLRASSCGGVFQTTPAPVVTTPPKDTCS
PVLLMSLIQPKCGNQVMTLALNKKHVQTLQCTITGLTFWDSSCQAEDTDDHLVLSSAYSSCGMKVTAHVV
SNEVIISFPSGSPPLRKKVQCIDMDSLSFQLGLYLSPHFLQASNTIELGQQAFVQVSVSPLTSEVTVQLD
SCHLDLGPEGDMVELIQSRTAKGSCVTLLSPSPEGDPRFSFLLRVYMVPTPTAGTLSCNLALRPSTLSQE
VYKTVSMRLNIVSPDLSGKGLVLPSVLGITFGAFLIGALLTAALWYIYSHTRGPSKREPVVAVAAPASSE
SSSTNHSIGSTQSTPCSTSSMA

Molecule Role Protective antigen
Molecule Role Annotation A study which combined endoglin plasmid DNA and recombinant protein as vaccines and used them to prime and boost, simultaneously, as a vaccine strategy was conducted. The results showed that combination of endoglin DNA and protein vaccines could enhance both protective and therapeutic anti-tumor efficacy in both colon carcinoma and Lewis lung carcinoma models. Significant inhibition of tumor angiogenesis was found in the tumor tissues. The titers of autoantibodies against murine endoglin were significantly increased and the antibody levels lasted longer in the mice with combined endoglin DNA and recombinant protein vaccination. CTL response against endoglin-positive HUVECs, but not against endoglin-negative tumor cells was found in the mice combined DNA with protein vaccination. In addition, combination of endoglin DNA and recombinant protein vaccination significantly induced IFN-gamma secreting cells (Tan et al., 2007).
Related Vaccines(s) Cancer DNA Vaccine encoding Endoglin Boosted with Recombinant Endoglin Protein
References