VIOLIN: Vaccine Investigation and Online Information Network

SMT
Gene Name	SMT
Sequence Strain (Species/Organism)	Leishmania infantum
VO ID	VO_0011282
NCBI Protein GI	146104463
Other Database IDs	CDD:332925 CDD:332923 CDD:312111 GOA:A4IDL3 InterPro: IPR013216 InterPro: IPR013705 UniProtKB/TrEMBL: A4IDL3
Taxonomy ID	435258
Gene Strand (Orientation)	?
Protein Name	putative sterol 24-c-methyltransferase
Protein pI	6.62
Protein Weight	38177.872
Protein Length	443
Protein Note	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; cl28104
Protein Sequence	>XP_001469832.1 putative sterol 24-c-methyltransferase [Leishmania infantum JPCM5] MSAGGRETAPTNLIRRRNKDETNGDVSAAADRFRDRFEKATLEERKAATTTMVNEYYDLVTDFYEYGWGQ NFHFAPRYAGETFFESLARHEYFLAARGGFMEGDHIVDVGCGVGGPARNMVRLTRCNVIGVNNNDYQISR ARRHDALAGMSSKIDYVKTDFCNMSLADNTFDGAYAIEATCHAKDKVKCYSEVFRVIKPGTCFVLYEWCM TDKYNPNDEYHRTIKHRIELGDGLPEMETCKQVIEYMKQAGFVVEEAIDVISQFESSPIKSIPWYQPLVG DYSSLQGLRSTPIGRILTNVMCRVLEFVRLAPKGTYKATEILEEAAESLVVGGQLGIFTPSFYIRARKPS KQA
Molecule Role	Protective antigen
Molecule Role Annotation	Upon challenge with L. infantum, C57BL/6 mice immunized with SMT formulated in MPL-SE adjuvant showed significantly lower parasite burdens in both spleens and livers compared with non-immunized mice or mice injected with adjuvant alone (Goto et al., 2007).
Related Vaccines(s)	L. infantum SMT Protein Vaccine
References