VIOLIN: Vaccine Investigation and Online Information Network

HBHA
Gene Name	HBHA
Sequence Strain (Species/Organism)	Mycobacterium tuberculosis H37Ra
VO ID	VO_0012373
NCBI Gene ID	5211814
NCBI Protein GI	148660242
Locus Tag	MRA_0482
Genbank Accession	CP000611
Protein Accession	YP_001281765
Taxonomy ID	25177
Gene Starting Position	567106
Gene Ending Position	567705
Gene Strand (Orientation)	+
Protein Name	iron-regulated heparin binding hemagglutinin Hbha
Protein pI	9.84
Protein Weight	20541.79
Protein Length	199
DNA Sequence	>NC_009525.1:567106-567705 Mycobacterium tuberculosis H37Ra, complete genome CATGGCTGAAAACTCGAACATTGATGACATCAAGGCTCCGTTGCTTGCCGCGCTTGGAGCGGCCGACCTG GCCTTGGCCACTGTCAACGAGTTGATCACGAACCTGCGTGAGCGTGCGGAGGAGACTCGTACGGACACCC GCAGCCGGGTCGAGGAGAGCCGTGCTCGCCTGACCAAGCTGCAGGAAGATCTGCCCGAGCAGCTCACCGA GCTGCGTGAGAAGTTCACCGCCGAGGAGCTGCGTAAGGCCGCCGAGGGCTACCTCGAGGCCGCGACTAGC CGGTACAACGAGCTGGTCGAGCGCGGTGAGGCCGCTCTAGAGCGGCTGCGCAGCCAGCAGAGCTTCGAGG AAGTGTCGGCGCGCGCCGAAGGCTACGTGGACCAGGCGGTGGAGTTGACCCAGGAGGCGTTGGGTACGGT CGCATCGCAGACCCGCGCGGTCGGTGAGCGTGCCGCCAAGCTGGTCGGCATCGAGCTGCCTAAGAAGGCT GCTCCGGCCAAGAAGGCCGCTCCGGCCAAGAAGGCCGCTCCGGCCAAGAAGGCGGCGGCCAAGAAGGCGC CCGCGAAGAAGGCGGCGGCCAAGAAGGTCACCCAGAAGTA
Protein Sequence	>YP_001281765.1 iron-regulated heparin binding hemagglutinin Hbha [Mycobacterium tuberculosis H37Ra] MAENSNIDDIKAPLLAALGAADLALATVNELITNLRERAEETRTDTRSRVEESRARLTKLQEDLPEQLTE LREKFTAEELRKAAEGYLEAATSRYNELVERGEAALERLRSQQSFEEVSARAEGYVDQAVELTQEALGTV ASQTRAVGERAAKLVGIELPKKAAPAKKAAPAKKAAPAKKAAAKKAPAKKAAAKKVTQK
Molecule Role	Protective antigen
Molecule Role Annotation	Purified preparations of HBHA were emulsified in a dimethyldioctadecylammonium bromide-monophosphoryl lipid A adjuvant and tested for the ability to reduce M. tuberculosis infection in the mouse aerosol challenge model for tuberculosis. The HBHA-containing vaccine gave a approximately 0.7-log reduction in CFU in both mouse lungs and spleens compared to adjuvant controls 28 days following challenge (Parra et al., 2004).
Related Vaccines(s)	M. tuberculosis HBHA Protein Vaccine
References

HBHA