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Vaccine Detail

S. pyogenes SfbI Protein Vaccine
Vaccine Information
  • Vaccine Name: S. pyogenes SfbI Protein Vaccine
  • Target Pathogen: Streptococcus pyogenes
  • Target Disease: Group A streptococcal infections, Strep throat, Scarlet fever
  • Vaccine Ontology ID: VO_0004056
  • Type: Subunit vaccine
  • Status: Research
  • Antigen: Recombinant SfbI protein
  • SfbI gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant: cholera toxin B subunit
  • Immunization Route: intranasal immunization
Host Response

Mouse Response

  • Host Strain: BALB/c
  • Vaccination Protocol: MIce were immunized intranasally with 20 μL of SfbI (H2 fragment) covalently coupled to CTB or with CTB alone as a control on days 1, 3, 5, and 26 (30 mg/dose) (Guzmán et al., 1999).
  • Challenge Protocol: On day 36 mice were challenged with 106 cfu of S. pyogenes DSM 2071 or NS239, respectively (Guzmán et al., 1999).
  • Efficacy: SfbI-vaccinated animals showed 80% and 90% protection against homologous and heterologous challenge (Guzmán et al., 1999).
References
Guzmán et al., 1999: Guzmán CA, Talay SR, Molinari G, Medina E, Chhatwal GS. Protective immune response against Streptococcus pyogenes in mice after intranasal vaccination with the fibronectin-binding protein SfbI. The Journal of infectious diseases. 1999; 179(4); 901-906. [PubMed: 10068585].