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Vaccine Detail

Salmonella Typhimurium ompD/nmpC mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Typhimurium ompD/nmpC mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0002900
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pig
  • NmpC gene engineering:
    • Type: Gene mutation
    • Description: This ompD/nmpC mutant is from Salmonella Typhimurium (Selke et al., 2007).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
Host Response

Pig Response

  • Persistence: An ompD/nmpc mutant is attenuated in pigs (Selke et al., 2007).
  • Efficacy: In a pig infection experiment including two oral immunizations with SalmoporcDeltaompD (OmpD, nmpC) and challenge with a multiresistant S. enterica serovar Typhimurium DT104 clinical isolate, we confirmed the protective efficacy of SalmoporcDeltaompD (Selke et al., 2007).
References
Selke et al., 2007: Selke M, Meens J, Springer S, Frank R, Gerlach GF. Immunization of pigs to prevent disease in humans: construction and protective efficacy of a Salmonella enterica serovar Typhimurium live negative-marker vaccine. Infection and immunity. 2007; 75(5); 2476-2483. [PubMed: 17296750].