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Vaccine Detail
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Salmonella Typhimurium ompD/nmpC mutant vaccine |
| Vaccine Information |
- Vaccine Name: Salmonella Typhimurium ompD/nmpC mutant vaccine
- Target Pathogen: Salmonella spp.
- Target Disease: Salmonellosis
- Vaccine Ontology ID: VO_0002900
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Pig
- NmpC
gene engineering:
- Type: Gene mutation
- Description: This ompD/nmpC mutant is from Salmonella Typhimurium (Selke et al., 2007).
- Detailed Gene Information: Click Here.
- Immunization Route: Oral immunization
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| Host Response |
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Pig Response
- Persistence: An ompD/nmpc mutant is attenuated in pigs (Selke et al., 2007).
- Efficacy: In a pig infection experiment including two oral immunizations with SalmoporcDeltaompD (OmpD, nmpC) and challenge with a multiresistant S. enterica serovar Typhimurium DT104 clinical isolate, we confirmed the protective efficacy of SalmoporcDeltaompD (Selke et al., 2007).
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| References |
Selke et al., 2007: Selke M, Meens J, Springer S, Frank R, Gerlach GF. Immunization of pigs to prevent disease in humans: construction and protective efficacy of a Salmonella enterica serovar Typhimurium live negative-marker vaccine. Infection and immunity. 2007; 75(5); 2476-2483. [PubMed: 17296750].
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