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Vaccine Detail

N. meningitidis ExbB Protein Vaccine
Vaccine Information
  • Vaccine Name: N. meningitidis ExbB Protein Vaccine
  • Target Pathogen: Neisseria meningitidis
  • Target Disease: Meningitis
  • Vaccine Ontology ID: VO_0004011
  • Type: Subunit vaccine
  • Status: Research
  • ExbB gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant: incomplete Freunds adjuvant
  • Immunization Route: Subcutaneous injection
Host Response

Mouse Response

  • Host Strain: BALB/c
  • Vaccination Protocol: To examine the protective efficacy of recombinant proteins, adult mice (6-week-old, female BALB/c animals, 35 per group) were immunised on days 1 and 21 with 25 μg of antigen given by subcutaneous (s.c.) injection. Each protein was mixed with Freund's incomplete adjuvant (50% v/v) prior to administration. Mice in control groups were immunised with adjuvant alone or recombinant homologous PorA prior to challenge (Sun et al., 2005).
  • Challenge Protocol: 28 days after immunization, animals were challenged with live bacteria at either a high (107 CFU, 15 mice) or low (106 CFU, 15 mice) dose of MC58 (Sun et al., 2005).
  • Efficacy: ExbB, which is required for iron acquisition, elicited protective immunity and was able to protect mice from bacterial challenge (Sun et al., 2005).
References
Sun et al., 2005: Sun Y, Li Y, Exley RM, Winterbotham M, Ison C, Smith H, Tang CM. Identification of novel antigens that protect against systemic meningococcal infection. Vaccine. 2005; 23(32); 4136-4141. [PubMed: 15964482].