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Vaccine Detail

P. falciparum Hsp90 Protein Subunit Vaccine
Vaccine Information
  • Vaccine Name: P. falciparum Hsp90 Protein Subunit Vaccine
  • Target Pathogen: Plasmodium spp.
  • Target Disease: Malaria
  • Vaccine Ontology ID: VO_0011396
  • Type: Subunit vaccine
  • Status: Research
  • Hsp90 gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant: complete Freunds adjuvant
  • Immunization Route: Subcutaneous injection
Host Response

Monkey Response

  • Host Strain: S. sciureus
  • Vaccination Protocol: Monkeys were immunized on days 0, 21, and 42 with 120/~g of protein in PBS/0.1% SDS. Each dose consisted of 1.5ml
    emulsified with Freund's complete adjuvant for the first immunization and Freund's incomplete adjuvant for the others, injected subcutaneously on multiple sites in the back. Control monkeys received the same treatment but without parasite proteins (Bonnefoy et al., 1994).
  • Challenge Protocol: All monkeys were challenged on day 56 by intravenous injection of 5 x 107 FUP/SP-infected monkey erythrocytes (Bonnefoy et al., 1994).
  • Efficacy: The three control monkeys showed a rapid rise of parasitaemia with a prepatent period of 2 days and required drug treatment within 7 days to prevent fatal outcome. Three immunized monkeys developed a reduced parasitaemia with a prepatent period of 2 to 6 days with a maximum peak of parasitaemia of 5-11.6% that dropped spontaneously. The two other immunized monkeys developed parasitaemia similar to the controls and were drug-cured at day 7 (Bonnefoy et al., 1994).
References
Bonnefoy et al., 1994: Bonnefoy S, Gysin J, Blisnick T, Guillotte M, Carcy B, Pereira da Silva L, Mercereau-Puijalon O. Immunogenicity and antigenicity of a Plasmodium falciparum protein fraction (90-110 kDa) able to protect squirrel monkeys against asexual blood stages. Vaccine. 1994; 12(1); 32-40. [PubMed: 8303938].