VIOLIN: Vaccine Investigation and Online Information Network

B5R

General Information

Protegen ID

1402

Sequence Strain (Species/Organism)

Vaccinia virus

Taxonomy ID

10245

Molecule Role

Protective antigen

Related Vaccines(s)

Vaccina Virus Vaccine A27/B5/CpG7909 , Vaccinia virus DNA vaccine B5R

References

Gene Information

Gene Name

B5R

NCBI Gene ID

3707658

Genbank Accession

A22016

Locus Tag

VACWR187

Gene Starting Position

168373

Gene Ending Position

169326

DNA Sequence

>NC_006998.1:168373-169326 Vaccinia virus, complete genome
AATGAAAACGATTTCCGTTGTTACGTTGTTATGCGTACTACCTGCTGTTGTTTATTCAACATGTACTGTA
CCCACTATGAATAACGCTAAATTAACGTCTACCGAAACATCGTTTAATGATAAACAGAAAGTTACGTTTA
CATGTGATCAGGGATATCATTCTTCGGATCCAAATGCTGTCTGCGAAACAGATAAATGGAAATACGAAAA
TCCATGCAAAAAAATGTGCACAGTTTCTGATTACATCTCTGAATTATATAATAAACCGCTATACGAAGTG
AATTCCACCATGACACTAAGTTGCAACGGCGAAACAAAATATTTTCGTTGCGAAGAAAAAAATGGAAATA
CTTCTTGGAATGATACTGTTACGTGTCCTAATGCGGAATGTCAACCTCTTCAATTAGAACACGGATCGTG
TCAACCAGTTAAAGAAAAATACTCATTTGGGGAATATATGACTATCAACTGTGATGTTGGATATGAGGTT
ATTGGTGCTTCGTACATAAGTTGTACAGCTAATTCTTGGAATGTTATTCCATCATGTCAACAAAAATGTG
ATATGCCGTCTCTATCTAATGGATTAATTTCCGGATCTACATTTTCTATCGGTGGCGTTATACATCTTAG
TTGTAAAAGTGGTTTTACACTAACGGGGTCTCCATCATCCACATGTATCGACGGTAAATGGAATCCCGTA
CTCCCAATATGTGTACGAACTAACGAAGAATTTGATCCAGTGGATGATGGTCCCGACGATGAGACAGATT
TGAGCAAACTCTCGAAAGACGTTGTACAATATGAACAAGAAATAGAATCGTTAGAAGCAACTTATCATAT
AATCATAGTGGCGTTAACAATTATGGGCGTCATATTTTTAATCTCCGTTATAGTATTAGTTTGTTCCTGT
GACAAAAATAATGACCAATATAAGTTCCATAAATTGCTACCGTA

Protein Information

Protein Name

EEV membrane glycoprotein

NCBI Protein GI

66275984

Protein Accession

YP_233069

Protein pI

4.46

Protein Weight

32549.54

Protein Length

317

Protein Note

EEV membrane glycoprotein; similar to vaccinia virus strain Copenhagen B5R and cowpox virus B4R; glycoprotein found on extracellular enveloped virions (EEV); The poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins;

Protein Sequence

>YP_233069.1 EEV type-I membrane glycoprotein [Vaccinia virus]
MKTISVVTLLCVLPAVVYSTCTVPTMNNAKLTSTETSFNDKQKVTFTCDQGYHSSDPNAVCETDKWKYEN
PCKKMCTVSDYISELYNKPLYEVNSTMTLSCNGETKYFRCEEKNGNTSWNDTVTCPNAECQPLQLEHGSC
QPVKEKYSFGEYMTINCDVGYEVIGASYISCTANSWNVIPSCQQKCDMPSLSNGLISGSTFSIGGVIHLS
CKSGFTLTGSPSSTCIDGKWNPVLPICVRTNEEFDPVDDGPDDETDLSKLSKDVVQYEQEIESLEATYHI
IIVALTIMGVIFLISVIVLVCSCDKNNDQYKFHKLLP

Vaxign Prediction

Localization(Probability)

(Prob.=0)

Adhesin Probability

0.463

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope