VIOLIN: Vaccine Investigation and Online Information Network

GP from Musoke Marburgvirus

General Information

Protegen ID

150

Sequence Strain (Species/Organism)

Lake Victoria marburgvirus - Musoke

VO ID

VO_0010961

Taxonomy ID

33727

Other Database IDs

CDD:279888
CDD:197367

Molecule Role

Protective antigen

Molecule Role Annotation

Study developed replication-competent vaccines against EBOV and MARV based on attenuated recombinant vesicular stomatitis virus vectors expressing either the EBOV glycoprotein or MARV glycoprotein from Lake Victoria marburgvirus - Musoke. A single intramuscular injection of the EBOV or MARV vaccine elicited completely protective immune responses in nonhuman primates against lethal EBOV or MARV challenges (Jones et al., 2005).

Related Vaccines(s)

Adenovirus vectors expressing Marburg virus glycoprotein , CAdVa-Filoviruses (EbMarburg viruses) , cAdVaxM(fus) , Heterologous MARV Protein VLP , Marburg virus DNA prime/boost vaccine DNA/rAd5-GP encoding GP from strain Angola , Marburg virus DNA vaccine DNA-GP encoding GP , Marburg virus glycoprotein expressed by baculovirus recombinants , Marburg virus recombinant vector vaccine CAdVax-Panfilo , Marburg virus recombinant vector vaccine MBGV GP , Marburg virus recombinant vector vaccine MBGV GP/MBGV NP , Marburg Virus Vaccine Ad26.Filo, MVA-BN-Filo , Marburg Virus Vaccine mVLP QS-21 Adjuvant , Marburg virus-like particles , Recombinant VEE Replicons expressing MBGV GP , VSV-based vaccine expressing MBGV GP

References

Jones et al., 2005: Jones SM, Feldmann H, StrÃ¶her U, Geisbert JB, Fernando L, Grolla A, Klenk HD, Sullivan NJ, Volchkov VE, Fritz EA, Daddario KM, Hensley LE, Jahrling PB, Geisbert TW. Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses. Nature medicine. 2005; 11(7); 786-790. [PubMed: 15937495].

Gene Information

Gene Name

GP from Musoke Marburgvirus

Protein Information

Protein Name

glycoprotein

NCBI Protein GI

77543430

Protein pI

6.35

Protein Weight

72821.63

Protein Length

755

Protein Note

Filovirus glycoprotein; pfam01611

Protein Sequence

>ABA87127.1 glycoprotein [Marburg virus - Musoke, Kenya, 1980]
MKTTCFLISLILIQGTKNLPILEIASNNQPQNVDSVCSGTLQKTEDVHLMGFTLSGQKVADSPLEASKRW
AFRTGVPPKNVEYTEGEEAKTCYNISVTDPSGKSLLLDPPTNIRDYPKCKTIHHIQGQNPHAQGIALHLW
GAFFLYDRIASTTMYRGKVFTEGNIAAMIVNKTVHKMIFSRQGQGYRHMNLTSTNKYWTSSNGTQTNDTG
CFGALQEYNSTKNQTCAPSKIPPPLPTARPEIKLTSTPTDATKLNTTDPSSDDEDLATSGSGSGEREPHT
TSDAVTKQGLSSTMPPTPSPQPSTPQQGGNNTNHSQDAVTELDKNNTTAQPSMPPHNTTTISTNNTSKHN
FSTLSAPLQNTTNDNTQSTITENEQTSAPSITTLPPTGNPTTAKSTSSKKGPATTAPNTTNEHFTSPPPT
PSSTAQHLVYFRRKRSILWREGDMFPFLDGLINAPIDFDPVPNTKTIFDESSSSGASAEEDQHASPNISL
TLSYFPNINENTAYSGENENDCDAELRIWSVQEDDLAAGLSWIPFFGPGIEGLYTAVLIKNQNNLVCRLR
RLANQTAKSLELLLRVTTEERTFSLINRHAIDFLLTRWGGTCKVLGPDCCIGIEDLSKNISEQIDQIKKD
EQKEGTGWGLGGKWWTSDWGVLTNLGILLLLSIAVLIALSCICRIFTKYIG

Epitope Information

IEDB Linear Epitope