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VP35

General Information
Protegen ID 167
Sequence Strain (Species/Organism) Marburg marburgvirus
VO ID VO_0010929
Taxonomy ID 11269
Molecule Role Protective antigen
Molecule Role Annotation Guinea pigs were vaccinated with recombinant VEE replicons (packaged into VEE-like particles), inoculated with MBGV, and evaluated for viremia and survival after challenge with typical MGBV disease. Results indicated that VP35 afforded incomplete protection (Hevey et al., 1998).
Related Vaccines(s) Marburg virus recombinant vector vaccine MBGV GP , Recombinant VEE Replicons expressing MBGV GP
References
Hevey et al., 1998: Hevey M, Negley D, Pushko P, Smith J, Schmaljohn A. Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates. Virology. 1998 Nov 10; 251(1); 28-37. [PubMed: 9813200 ].
Gene Information
Gene Name VP35
NCBI Gene ID 920948
Genbank Accession NC_001608.2
Locus Tag MARV_gp2
Gene Starting Position 2853
Gene Ending Position 4409
DNA Sequence 
>NC_001608.3:2853-4409 Marburg marburgvirus isolate Marburg virus/H.sapiens-tc/KEN/1980/Mt. Elgon-Musoke, complete genome
CGAAGAATATTAAAGATTTTCTTTAATATTCAGAAAAGGCTTTTTATTCTATTCTTTCTTTTTACAAACG
TATTGAAATAGTAATTCTCACAATGTGGGACTCATCATACATGCAGCAAGTCAGCGAAGGGTTGATGACT
GGAAAAGTACCCATAGATCAAGTGTTTGGTGCCAATCCCTTAGAGAAGTTATACAAGAGAAGAAAACCAA
AAGGCACAGTTGGACTACAATGTAGCCCTTGTCTAATGTCAAAGGCGACAAGTACTGATGATATTATTTG
GGACCAACTGATCGTGAAGAGAACACTAGCTGATCTACTTATACCGATAAATAGGCAGATATCAGACATT
CAAAGCACTCTAAGCGAAGTAACAACAAGAGTCCATGAAATTGAGCGGCAATTACATGAGATTACCCCAG
TTTTAAAAATGGGAAGGACACTGGAAGCAATTTCCAAGGGGATGTCAGAAATGTTAGCCAAATACGACCA
CCTTGTAATTTCAACTGGAAGAACCACTGCACCAGCTGCTGCCTTTGATGCCTACTTAAATGAGCATGGT
GTCCCTCCCCCTCAACCCGCGATTTTCAAAGATCTTGGGGTTGCCCAACAAGCTTGTAGTAAGGGGACCA
TGGTTAAAAATGCAACAACAGATGCAGCCGACAAGATGTCGAAGGTTCTTGAACTCAGTGAGGAAACGTT
CTCCAAGCCAAACCTTTCAGCTAAGGATTTAGCCCTTTTATTGTTTACCCATCTACCCGGCAACAACACT
CCATTCCATATCCTAGCTCAGGTCCTTTCAAAAATTGCTTACAAGTCAGGAAAATCCGGAGCATTCTTGG
ATGCATTTCACCAGATTCTAAGTGAAGGAGAGAATGCTCAGGCGGCATTAACTCGACTAAGCAGAACATT
TGACGCTTTCCTTGGAGTGGTTCCTCCAGTGATAAGAGTCAAAAACTTCCAAACAGTCCCTCGTCCATGT
CAAAAAAGTCTTCGGGCTGTCCCTCCAAATCCAACAATTGACAAAGGATGGGTCTGTGTTTATTCATCTG
AGCAAGGTGAAACACGGGCCCTTAAAATCTAATTCTCATTGTTCATAGTTGCAAGGGAAGTGATCTTTCC
GAGTTGATACAAAGACACTAAACATTTCAAAAGCATGTATGTGGACAAAACATAATTAGACCATCTTAAT
TGGAGTAGTAATTTATTTCTGTCTTAAATGTGATTTTCACTTTAAAAGCGTTAAATGGTGATAGATTAAT
CCTTGAAGTTACTCTTCTATATATTATAGAGAAACCAATGTTACTAACAAAAGGGGTCTACCTAACGCAT
ATGATTGAGTAATCCGTATATTTTATAAACCAAACAATTAACTTCTTACTTTTTAAGAATCAACTAACAA
CATAGAAAAGACATTTATCCTTATGTAATCCTCGGCTTAGTTGAAATTAACTTTTGTTGGACCTCAAGAC
GCTTATTCATAGTATATTATATGATTTTTTATAAGTTTAAGATATCTTAAATTATACCCACAAAAGATAC
TGTTTTAATTAAGAAAA
Protein Information
Protein Name mRNA
NCBI Protein GI 158539110
Protein Accession YP_001531154
Protein pI 9.15
Protein Weight 33975.62
Protein Length 329
Protein Sequence 
>YP_001531154.1 polymerase complex protein [Marburg marburgvirus]
MWDSSYMQQVSEGLMTGKVPIDQVFGANPLEKLYKRRKPKGTVGLQCSPCLMSKATSTDDIIWDQLIVKR
TLADLLIPINRQISDIQSTLSEVTTRVHEIERQLHEITPVLKMGRTLEAISKGMSEMLAKYDHLVISTGR
TTAPAAAFDAYLNEHGVPPPQPAIFKDLGVAQQACSKGTMVKNATTDAADKMSKVLELSEETFSKPNLSA
KDLALLLFTHLPGNNTPFHILAQVLSKIAYKSGKSGAFLDAFHQILSEGENAQAALTRLSRTFDAFLGVV
PPVIRVKNFQTVPRPCQKSLRAVPPNPTIDKGWVCVYSSEQGETRALKI
Epitope Information
IEDB Linear Epitope