VIOLIN: Vaccine Investigation and Online Information Network

F protein

General Information

Protegen ID

1670

Sequence Strain (Species/Organism)

Human respiratory syncytial virus

Taxonomy ID

208893

Other Database IDs

CDD:278924
GOA:E0WLR1
InterPro: IPR000776
UniProtKB/TrEMBL: E0WLR1

Molecule Role

Protective antigen

Molecule Role Annotation

(Oomens et al., 2006)HRSV F protein CT plays a critical role in F protein cellular localization and production of infectious virus. HRSV F protein can induce membrane fusion in the absence of the homotypic attachment protein.

Related Vaccines(s)

Ad5-RSV-F , HDAd-sFsyn , HRSV DNA vaccine DRF-412 , MEDI-534 , Mnull RSV , MVA - RSV , rB-HPIV3-F1 , rB-HPIV3-G1 , rB/HPIV3- RSV-F , Respiratory syncytal virus bivalent prefusion F vaccine , rPIV3-RSV-hMPV , RSV/Î”NS2/Î”1313/I1314 , rVSV-Gstem-RSV-F , VSV-RSV(F/G)

References

Oomens et al., 2006: Oomens AG, Bevis KP, Wertz GW. The cytoplasmic tail of the human respiratory syncytial virus F protein plays critical roles in cellular localization of the F protein and infectious progeny production. Journal of virology. 2006; 80(21); 10465-10477. [PubMed: 16928754].

Gene Information

Gene Name

F protein

Protein Information

Protein Name

F protein

NCBI Protein GI

306438651

Protein pI

10.23

Protein Weight

18105.35

Protein Length

239

Protein Note

Fusion glycoprotein F0; pfam00523

Protein Sequence

>CBW45366.1 F protein, partial [Human respiratory syncytial virus A]
MELPILKTNAITTIFAAVTLCFASSQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCN
GTDAKVKLIKQELDKYKNAVTELQLLMQSTPAANNRARRELPRFMNYTLNNTKNNNVTLSKKRKRRFLGF
LLGVGSAIASGIAVSKVLHLEGEVNK

Epitope Information

IEDB Linear Epitope