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FimH from E. coli str. K-12 substr. MG1655

General Information
Protegen ID 281
Sequence Strain (Species/Organism) Escherichia coli str. K-12 substr. MG1655
VO ID VO_0010987
Taxonomy ID 511145
Molecule Role Protective antigen
Molecule Role Annotation Antibodies directed at the putative binding region of FimH (anti- s-FimH1-25) significantly reduced E. coli bladder infections in the experimental mouse model of urinary tract infections (Thankavel et al., 1997).
Related Vaccines(s) E. coli FimH with CFA and then IFA , KLH-s-FimH1-25 with CFA and then IFA
References
Thankavel et al., 1997: Thankavel K, Madison B, Ikeda T, Malaviya R, Shah AH, Arumugam PM, Abraham SN. Localization of a domain in the FimH adhesin of Escherichia coli type 1 fimbriae capable of receptor recognition and use of a domain-specific antibody to confer protection against experimental urinary tract infection. The Journal of clinical investigation. 1997; 100(5); 1123-1136. [PubMed: 9276729].
Gene Information
Gene Name FimH from E. coli str. K-12 substr. MG1655
NCBI Gene ID 948847
Genbank Accession CP009685
Locus Tag b4320
Gene Starting Position 4548807
Gene Ending Position 4549709
DNA Sequence 
>NC_000913.3:4548807-4549709 Escherichia coli str. K-12 substr. MG1655, complete genome
AATGAAACGAGTTATTACCCTGTTTGCTGTACTGCTGATGGGCTGGTCGGTAAATGCCTGGTCATTCGCC
TGTAAAACCGCCAATGGTACCGCTATCCCTATTGGCGGTGGCAGCGCCAATGTTTATGTAAACCTTGCGC
CCGTCGTGAATGTGGGGCAAAACCTGGTCGTGGATCTTTCGACGCAAATCTTTTGCCATAACGATTATCC
GGAAACCATTACAGACTATGTCACACTGCAACGAGGCTCGGCTTATGGCGGCGTGTTATCTAATTTTTCC
GGGACCGTAAAATATAGTGGCAGTAGCTATCCATTTCCTACCACCAGCGAAACGCCGCGCGTTGTTTATA
ATTCGAGAACGGATAAGCCGTGGCCGGTGGCGCTTTATTTGACGCCTGTGAGCAGTGCGGGCGGGGTGGC
GATTAAAGCTGGCTCATTAATTGCCGTGCTTATTTTGCGACAGACCAACAACTATAACAGCGATGATTTC
CAGTTTGTGTGGAATATTTACGCCAATAATGATGTGGTGGTGCCTACTGGCGGCTGCGATGTTTCTGCTC
GTGATGTCACCGTTACTCTGCCGGACTACCCTGGTTCAGTGCCAATTCCTCTTACCGTTTATTGTGCGAA
AAGCCAAAACCTGGGGTATTACCTCTCCGGCACAACCGCAGATGCGGGCAACTCGATTTTCACCAATACC
GCGTCGTTTTCACCTGCACAGGGCGTCGGCGTACAGTTGACGCGCAACGGTACGATTATTCCAGCGAATA
ACACGGTATCGTTAGGAGCAGTAGGGACTTCGGCGGTGAGTCTGGGATTAACGGCAAATTATGCACGTAC
CGGAGGGCAGGTGACTGCAGGGAATGTGCAATCGATTATTGGCGTGACTTTTGTTTATCAATA
Protein Information
Protein Name type 1 fimbriae D-mannose specific adhesin
NCBI Protein GI 16132141
Protein Accession NP_418740
Protein pI 7.88
Protein Weight 27803.36
Protein Length 300
Protein Note minor fimbrial subunit, D-mannose specific adhesin
Protein Sequence 
>NP_418740.1 type 1 fimbriae D-mannose specific adhesin [Escherichia coli str. K-12 substr. MG1655]
MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPVVNVGQNLVVDLSTQIFCHNDYP
ETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVA
IKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAK
SQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYART
GGQVTAGNVQSIIGVTFVYQ
Vaxign Prediction
Localization(Probability) Unknown
(Prob.=0.465)
Adhesin Probability 0.958
Trans-membrane Helices 0
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope