VIOLIN: Vaccine Investigation and Online Information Network

IroN

General Information

Protegen ID

318

Sequence Strain (Species/Organism)

Salmonella enterica subsp. enterica serovar Typhimurium

VO ID

VO_0010997

Taxonomy ID

90371

Other Database IDs

CDD:237410

Molecule Role

Protective antigen

Molecule Role Annotation

Thirty-day-old chickens were immunized intramuscularly with purified IroN from Salmonella Typhimurium mixed with Freund's incomplete adjuvant; the chickens were then challenged intravenously with Salmonella Enteritidis. The mortality rate of immunized chickens was 10%. On the other hand, that of control chickens was 80% (Kaneshige et al., 2009).

Related Vaccines(s)

Salmonella IroN Protein Vaccine

References

Kaneshige et al., 2009: Kaneshige T, Yaguchi K, Ohgitani T. Siderophore receptor IroN is an important protective antigen against Salmonella infection in chickens. Avian diseases. 2009; 53(4); 563-567. [PubMed: 20095157].

Gene Information

Gene Name

IroN

Protein Information

NCBI Protein GI

259475459

Protein pI

6.28

Protein Weight

79296.4

Protein Length

857

Protein Note

outer membrane receptor FepA; Provisional

Protein Sequence

>CBF90638.1 unnamed protein product [Salmonella enterica subsp. enterica serovar Typhimurium]
MNKKIHSLTLLVNLGIYGATLPVMAEDKTDSAALTNEDTIVVTAAQQNLQAPGVSTITADEIRKNPPARD
VSEIIRTMPGVNLTGNSTSGQRGNNRQIDIRGMGPENTLILIDGKPVTSRNSVRLGWRGERDTRGDTAWV
PPEMIERIEVLRGPAAARYGNGAAGGVVNIITKKGGSEWHGSWNTYFNAPEHKDEGATKRTNFSLNGPLG
GDFSFRLYGNLDKTQADARNINQGHQSERTGSYADTLPAGREGVINKDINGVVRWDFAPLQSLELEAGYS
RQGNLYAGDTQNTNTNQLVKDNYGKETNRLYRQNYSLTWNGGWNNGVTTSNWVQYEHTRNSRMPEGLAGG
TEGIFDPKASQKYADADLNDVTLHSEVSLPFDLLVNQNLTLGTEWAQQRMKDQLSNSQTFMGGNIPGYSS
TNRSPYSKAEIFSLFAENNMELTDSTMLTPGLRFDHHSIVGDNWSPSLNLSQGLGDDFTLKMGIARAYKA
PSLYQTNPNYILYSKGQGCYATGAGTGIGCYMMGNDDLKAETSINKEIGLEFKRDGWLAGVTWFRNDYRN
KIEAGTVPLQRINNGKTDVYQWENVPKAVVEGLEGTLNVPVSDTVNWTNNVTYMLQSKNKETGERLSIIP
QYTLNSTLSWQVRQDVSLQSTFTWYGKQEPKKYDYQGNPVTGTDKQAVSPYSIVGLSATWDVTKNVSLTG
GVDNLFDKRLWREGNAQTVRDTQTGAYMAGAGAYTYNEPGRTWYMSINTHF

Epitope Information

IEDB Linear Epitope