VIOLIN: Vaccine Investigation and Online Information Network

YscF from Y. pestis KIM 10

General Information

Protegen ID

338

Sequence Strain (Species/Organism)

Yersinia pestis

VO ID

VO_0011001

Taxonomy ID

632

Molecule Role

Protective antigen

Molecule Role Annotation

Modified YscF antigens were able to partially protect immunized mice at various levels against lethal challenge with Y. pestis KIM 1001 strain (Wang et al., 2008).

Related Vaccines(s)

Y. pestis DNA vaccine YscF-2

References

Wang et al., 2008: Wang S, Joshi S, Mboudjeka I, Liu F, Ling T, Goguen JD, Lu S. Relative immunogenicity and protection potential of candidate Yersinia Pestis antigens against lethal mucosal plague challenge in Balb/C mice. Vaccine. 2008; 26(13); 1664-1674. [PubMed: 18291562].

Gene Information

Gene Name

YscF from Y. pestis KIM 10

NCBI Gene ID

1149286

Genbank Accession

AF053946

Locus Tag

D744_p5023

Plasmid No

pCD1

Gene Starting Position

19544

Gene Ending Position

19807

DNA Sequence

>NC_004839.1:19544-19807 Yersinia pestis strain KIM5 plasmid pCD1, complete sequence
ATTATGGGAACTTCTGTAGGATGCCTTGCATTAAGTCTTTCATGCTACGAACTATGGTTGAGTTTATATT
GTAAATTACCGACCATTTATTAATTGAATGTTGTAAGTCAGCAAGTAGCGCCGGGTTGTCAGGCTTATCT
TTCAATGCTGCTATCGAGTCATTAACCGCTTTGTTTGCATCGTCTGCTGGCTTCTTGAGCGTTTGAGCCA
CCGCATCTAAGTCTGCGATATCGGTTCCTTTCGTAAATCCAGAGAAGTTACTCA

Protein Information

Protein Name

type III secretion protein

NCBI Protein GI

31795470

Protein Accession

NP_857922

Protein pI

7.54

Protein Weight

9092.63

Protein Length

Protein Note

type III secretion apparatus component

Protein Sequence

>NP_857922.1 type III secretion protein (plasmid) [Yersinia pestis]
MSNFSGFTKGTDIADLDAVAQTLKKPADDANKAVNDSIAALKDKPDNPALLADLQHSINKWSVIYNINST
IVRSMKDLMQGILQKFP

Epitope Information

IEDB Linear Epitope