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FlaC

General Information
Protegen ID 400
Sequence Strain (Species/Organism) Campylobacter jejuni subsp. jejuni 81-176
VO ID VO_0011048
Taxonomy ID 354242
Molecule Role Protective antigen
Molecule Role Annotation Immunogenicity and protective efficacy of three Campylobacter jejuni flagellum-secreted proteins, FlaC, FspA1, and FspA2, were compared by use of a mouse model. All three proteins were immunogenic, FlaC provided an 18% protection against disease from C. jejuni 81-176 (Baqar et al., 2008).
COG COG1344N, under N: Cell motility
Related Vaccines(s) C. jejuni FlaC protein vaccine
References
Baqar et al., 2008: Baqar S, Applebee LA, Gilliland TC Jr, Lee LH, Porter CK, Guerry P. Immunogenicity and protective efficacy of recombinant Campylobacter jejuni flagellum-secreted proteins in mice. Infection and immunity. 2008; 76(7); 3170-3175. [PubMed: 18426878].
Gene Information
Gene Name FlaC
NCBI Gene ID 4682885
Genbank Accession CP000538
Locus Tag CJJ81176_0743
Gene Starting Position 671962
Gene Ending Position 672711
DNA Sequence 
>NC_008787.1:671962-672711 Campylobacter jejuni subsp. jejuni 81-176, complete genome
ATTATTGTAATAAATTAGCAATTTTGCTTTGAAGCTGCATGTTGGATTGCGCAGCAACAAAAGCAGCAGC
ATTTTCTTTTAGATAATTGGCATTAAAATCATTAACATTTTTTGCCATATCATTATTTAGTAAATTATTT
TCAGCTGCTTTTGAGTTGATGCTATTTTGAACACTTGCATTAATATTTGATGTAATGGCATTGATACCTG
AACCTATTTCACTTCTTAAACTTCCAAGTTGATCCATAAAATTTGTAATACTATCTTGATTATCTATGCT
TAATCCACCTGTTGCTAATGGATTTAAATTTGTAGTTTCAGTTCCGCTACCTACTACAAAATTCATAGTT
TGAAAGACATTTTTTCCATTATAAGTTGCATTATTAAAAGAATTATTGATGGATTCTTGTATGCGTGTTG
CTTCTGTTCTTAGCATTCCTTTTTGAGAATCATTAAGTGCAGCATTGTTCATTTTTACTGAAAGTTCATT
AAGTCTATCTGCGCTTTGAGAGATATTGGTAAGGCTAGCATCTGCAATTTGTAAAACCCCTATAGCATCA
TAAGCATTTGCGACACCTTGATCTATAGTGCTTGATTGAGATCTTAAAGAATCAGCAATAGCTAAATTAG
CACTATCAACTCCACTTATTGCGCGAACAGCTGCAATATTTTCTAAAGCTTTATCGCTAGCTTTTTGTGC
ATTATTTAAATAATAATTTTGTTGCATCATAGTTGCATCAGAGATCATCA
Protein Information
Protein Name flagellin subunit protein FlaC
NCBI Protein GI 121612344
Protein Accession YP_001000416
Protein pI 4.32
Protein Weight 25481.71
Protein Length 249
Protein Note identified by match to protein family HMM PF00669
Protein Sequence 
>YP_001000416.1 flagellin subunit protein FlaC [Campylobacter jejuni subsp. jejuni 81-176]
MMISDATMMQQNYYLNNAQKASDKALENIAAVRAISGVDSANLAIADSLRSQSSTIDQGVANAYDAIGVL
QIADASLTNISQSADRLNELSVKMNNAALNDSQKGMLRTEATRIQESINNSFNNATYNGKNVFQTMNFVV
GSGTETTNLNPLATGGLSIDNQDSITNFMDQLGSLRSEIGSGINAITSNINASVQNSINSKAAENNLLNN
DMAKNVNDFNANYLKENAAAFVAAQSNMQLQSKIANLLQ
Epitope Information
IEDB Linear Epitope