VIOLIN: Vaccine Investigation and Online Information Network

UL27

General Information

Protegen ID

500

Sequence Strain (Species/Organism)

Herpes simplex virus type 2

VO ID

VO_0011097

Taxonomy ID

10310

Other Database IDs

CDD:223014
GOA:P08666
InterPro: IPR000234
UniProtKB/UniProt: P08666

Molecule Role

Protective antigen

Molecule Role Annotation

The present study evaluated the modulatory functions of salbutamol co-administered with DNA vaccine expressing gB (UL27) of herpes simplex virus (HSV) via intranasal (i.n.) route. The enhanced immune responses caused by co-administration of salbutamol provided effective and rapid responses to HSV mucosal challenge, thereby conferring prolonged survival and reduced inflammation against viral infection (Kim et al., 2009).

Related Vaccines(s)

Herpes simplex virus DNA vaccine âˆ†gB-2 encoding gB , Herpes simplex virus DNA vaccine encoding gD and gB from HSV-2 strain Curtis , Herpes simplex virus type 2 DNA vaccine encoding GB

References

Kim et al., 2009: Kim SB, Han YW, Rahman MM, Kim SJ, Yoo DJ, Kang SH, Kim K, Eo SK. Modulation of protective immunity against herpes simplex virus via mucosal genetic co-transfer of DNA vaccine with beta2-adrenergic agonist. Experimental & molecular medicine. 2009; 41(11); 812-823. [PubMed: 19641376].

Gene Information

Gene Name

UL27

Protein Information

Protein Name

glycoprotein B

NCBI Protein GI

1869850

Protein pI

8.42

Protein Weight

93087.81

Protein Length

972

Protein Note

glycoprotein BALF4; Provisional

Protein Sequence

>CAB06752.1 glycoprotein B [Human alphaherpesvirus 2]
MRGGGLICALVVGALVAAVASAAPAAPAAPRASGGVAATVAANGGPASRPPPVPSPATTKARKRKTKKPP
KRPEATPPPDANATVAAGHATLRAHLREIKVENADAQFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEG
IAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINTKGVCRSTAKYVR
NNMETTAFHRDDHETDMELKPAKVATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPYD
EFVLATGDFVYMSPFYGYREGSHTEHTSYAADRFKQVDGFYARDLTTKARATSPTTRNLLTTPKFTVAWD
WVPKRPAVCTMTKWQEVDEMLRAEYGGSFRFSSDAISTTFTTNLTEYSLSRVDLGDCIGRDAREAIDRMF
ARKYNATHIKVGQPQYYLATGGFLIAYQPLLSNTLAELYVREYMREQDRKPRNATPAPLREAPSANASVE
RIKTTSSIEFARLQFTYNHIQRHVNDMLGRIAVAWCELQNHELTLWNEARKLNPNAIASATVGRRVSARM
LGDVMAVSTCVPVAPDNVIVQNSMRVSSRPGTCYSRPLVSFRYEDQGPLIEGQLGENNELRLTRDALEPC
TVGHRRYFIFGGGYVYFEEYAYSHQLSRADVTTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLDYT
EVQRRNQLHDLRFADIDTVIRADANAAMFAGLCAFFEGMGDLGRAVGKVVMGVVGGVVSAVSGVSSFMSN
PFGALAVGLLVLAGLVAAFFAFRYVLQLQRNPMKALYPLTTKELKTSDPGGVGGEGEEGAEGGGFDEAKL
AEAREMIRYMALVSAMERTEHKARKKGTSALLSSKVTNMVLRKRNKARYSPLHNEDEAGDEDEL

Epitope Information

IEDB Linear Epitope