VIOLIN: Vaccine Investigation and Online Information Network

ICP27 from Herpes simplex virus type 2

General Information

Protegen ID

503

Sequence Strain (Species/Organism)

Herpes simplex virus type 2

VO ID

VO_0011100

Taxonomy ID

10315

Other Database IDs

CDD:293457
CDD:283185

Molecule Role

Protective antigen

Molecule Role Annotation

Particle-mediated DNA vaccination of mice with a DNA plasmid-encoding ICP27 resulted in the induction of ICP27-specific IFN-gamma and TNF-alpha production in Balb/c mice. When the DNA vaccine was supplemented with as little as 50ng of a vector encoding the A and B subunits of the Escherichia coli heat labile enterotoxin (LT), animals were profoundly protected from morbidity and mortality (Haynes et al., 2006).

Related Vaccines(s)

Herpes simplex virus type 2 DNA vaccine encoding ICP27

References

Haynes et al., 2006: Haynes JR, Arrington J, Dong L, Braun RP, Payne LG. Potent protective cellular immune responses generated by a DNA vaccine encoding HSV-2 ICP27 and the E. coli heat labile enterotoxin. Vaccine. 2006; 24(23); 5016-5026. [PubMed: 16621198].

Gene Information

Gene Name

ICP27 from Herpes simplex virus type 2

Protein Information

Protein Name

mRNA export factor

NCBI Protein GI

124181

Protein pI

7.52

Protein Weight

56538.03

Protein Length

697

Protein Note

Immediate-early protein IE63; Infected cell protein 27; VMW63; ICP27

Protein Sequence

>sp|P28276.1|ICP27_HHV2H RecName: Full=mRNA export factor; AltName: Full=Immediate-early protein IE63; AltName: Full=Infected cell protein 27; Short=ICP27; AltName: Full=VMW63
MATDIDMLIDLGLDLSDSELEEDALERDEEGRRDDPESDSSGECSSSDEDMEDPCGDGGAEAIDAAIPKG
PPARPEDAGTPEASTPRPAARRGADDPPPATTGVWSRLGTRRSASPREPHGGKVARIQPPSTKAPHPRGG
RRGRRRGRGRYGPGGADSTPKPRRRVSRNAHNQGGRHPASARTDGPGATHGEARRGGEQLDVSGGPRPRG
TRQAPPPLMALSLTPPHADGRAPVPERKAPSADTIDPAVRAVLRSISERAAVERISESFGRSALVMQDPF
GGMPFPAANSPWAPVLATQAGGFDAETRRVSWETLVAHGPSLYRTFAANPRAASTAKAMRDCVLRQENLI
EALASADETLAWCKMCIHHNLPLRPQDPIIGTAAAVLENLATRLRPFLQCYLKARGLCGLDDLCSRRRLS
DIKDIASFVLVILARLANRVERGVSEIDYTTVGVGAGETMHFYIPGACMAGLIEILDTHRQECSSRVCEL
TASHTIAPLYVHGKYFYCNSLF

Epitope Information

IEDB Linear Epitope