VIOLIN: Vaccine Investigation and Online Information Network

HA from Influenza A virus (A/Viet Nam/1203/2004(H5N1))

General Information

Protegen ID

545

Sequence Strain (Species/Organism)

Influenza A virus (A/Viet Nam/1203/2004(H5N1))

VO ID

VO_0011138

Taxonomy ID

284218

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

Researchers evaluated the immunogenicity and efficacy of a panel of flagellin-based hemagglutinin (HA) globular head fusion vaccines in inbred mice. The HA globular head of these vaccines was derived from the A/Vietnam/1203/04 (VN04; H5N1) HA molecule. Results show that replacement of domain D3 of flagellin with the VN04 HA globular head creates a highly effective vaccine that elicits protective HAI titers which protect mice against disease and death in a lethal challenge model with H5 VN virus (Song et al., 2009).

Related Vaccines(s)

Avian influenza virus DNA vaccine pH5HA , BV-H5/H7/H9 , dVV-HA5(H5N1) , Flagellin-based HA globular head fusion vaccine using HA protein from Influenza A virus (A/Viet Nam/1203/2004(H5N1))

References

Song et al., 2009: Song L, Zhang Y, Yun NE, Poussard AL, Smith JN, Smith JK, Borisevich V, Linde JJ, Zacks MA, Li H, Kavita U, Reiserova L, Liu X, Dumuren K, Balasubramanian B, Weaver B, Parent J, Umlauf S, Liu G, Huleatt J, Tussey L, Paessler S. Superior efficacy of a recombinant flagellin:H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin. Vaccine. 2009; 27(42); 5875-5884. [PubMed: 19654064].

Gene Information

Gene Name

HA from Influenza A virus (A/Viet Nam/1203/2004(H5N1))

Protein Information

Protein Name

hemagglutinin

NCBI Protein GI

159144921

3D structure: PDB ID

2FK0

Protein pI

6.45

Protein Weight

61425.16

Protein Length

649

Protein Note

Haemagglutinin; pfam00509

Protein Sequence

>ABW90135.1 hemagglutinin [Influenza A virus (A/Viet Nam/1203/2004(H5N1))]
MEKIVLLFAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKKHNGKLCDLDGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSS
HEASLGVSSACPYQGKSSFFRNVVWLINKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNP
TTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSTI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRETRGLFGAIAG
FIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIE
NLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKCDNEC
MESVRNGTYDYPQYSEEARLKREEISGVKLESIGIYQILSIYSTVASSLALAIMVAGLSLWMCSNGSLQC
RICI

Epitope Information

IEDB Linear Epitope