VIOLIN: Vaccine Investigation and Online Information Network

msp3

General Information

Protegen ID

636

Sequence Strain (Species/Organism)

Plasmodium falciparum

VO ID

VO_0011220

Taxonomy ID

5833

Other Database IDs

CDD:284533
InterPro: IPR010784
UniProtKB/TrEMBL: Q0KGB6

Molecule Role

Protective antigen

Molecule Role Annotation

Immunization with a recombinant yeast-expressed Plasmodium falciparum merozoite surface protein 3 (MSP3) protected Aotus nancymai monkeys against a virulent challenge infection (Tsai et al., 2009).

Related Vaccines(s)

MSP3-CRM-Vac4All/ AlhydrogelÂ® , P. falciparum MSP3 Protein Subunit Vaccine

References

Tsai et al., 2009: Tsai CW, Duggan PF, Jin AJ, Macdonald NJ, Kotova S, Lebowitz J, Hurt DE, Shimp RL Jr, Lambert L, Miller LH, Long CA, Saul A, Narum DL. Characterization of a protective Escherichia coli-expressed Plasmodium falciparum merozoite surface protein 3 indicates a non-linear, multi-domain structure. Molecular and biochemical parasitology. 2009; 164(1); 45-56. [PubMed: 19073223].

Gene Information

Gene Name

msp3

NCBI Gene ID

810502

Protein Information

Protein Name

merozoite surface protein 3

NCBI Protein GI

113207288

Protein pI

4.26

Protein Weight

33643.59

Protein Length

383

Protein Note

Merozoite surface protein (SPAM); pfam07133

Protein Sequence

>CAJ44236.1 merozoite surface protein 3, partial [Plasmodium falciparum]
SKEIVKKYNLNLRNAILNNNSQIENEENVNTTITGNDFSGGEFLWPGYTEELKAKKASEDAEKAANDAEN
ASKEAEEAAKEAVNLKESDKSYTKAKEACTAASKAKKAVETALKAKDDAEKSSKADSISTKTKEYAEKAK
NAYEKAKNAYQKANQAVLKAKEASSYDYILGWEFGGGVPEHKKEENMLSHLYVSSKDKENISKENDDVLD
EKEEEAEETEEEELEEKNEEETESEISEDEEEEEEEEEKEEENDKKKEQEKEQSNENNDQKKDMEAQNLI
SKNQNNNEKNVKEAAESIMKTLAG

Epitope Information

IEDB Linear Epitope