VIOLIN: Vaccine Investigation and Online Information Network

UL44

General Information

Protegen ID

655

Sequence Strain (Species/Organism)

Suid alphaherpesvirus 1

VO ID

VO_0011239

Taxonomy ID

10345

Molecule Role

Protective antigen

Molecule Role Annotation

A trial vaccine containing pseudorabies virus (PRV) glycoprotein gC as the main component showed excellent protection against virulent virus infection in pigs (Katayama et al., 1997).

Related Vaccines(s)

Pseduorabies Subunit Glycoprotein C Vaccine

References

Katayama et al., 1997: Katayama S, Okada N, Yoshiki K, Okabe T, Shimizu Y. Protective effect of glycoprotein gC-rich antigen against pseudorabies virus. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 1997; 59(8); 657-663. [PubMed: 9300361].

Gene Information

Gene Name

UL44

NCBI Gene ID

2952505

Genbank Accession

BK001744

Locus Tag

SuHV1_gp30

Gene Starting Position

53985

Gene Ending Position

55504

DNA Sequence

>NC_006151.1:53985-55504 Suid herpesvirus 1, complete genome
TTTTAAAACCGCGATGGGGGGACGGGGGGCCATTCGCACGCGCCATGGCCTCGCTCGCGCGTGCGATGCT
CGCTCTGCTGGCGCTCTACGCGGCGGCCATCGCCGCGGCGCCGTCGACCACGACGGCGCTCGACACGACG
CCCAACGGGGGCGGCGGCGGCAACAGCAGCGAGGGAGAACTCTCGCCCTCTCCGCCCCCGACCCCCGCGC
CCGCCTCGCCCGAGGCGGGCGCGGTCTCGACGCCCCCGGTCCCGCCGCCCTCGGTCTCGCGCAGGAAGCC
CCCGCGGAACAACAACCGGACGCGCGTCCACGGCGACAAGGCCACCGCGCACGGGCGCAAGCGCATCGTG
TGCCGGGAGCGGCTGTTCTCGGCGCGGGTGGGGGACGCGGTCAGCTTCGGGTGCGCCGTCTTCCCGCGCG
CCGGGGAGACCTTCGAGGTCCGCTTCTACCGCCGCGGGCGCTTCCGCTCGCCCGACGCCGACCCCGAGTA
CTTTGACGAGCCCCCGCGCCCGGAGCTCCCGCGGGAGCGGCTCCTCTTCAGCTCCGCCAACGCCTCCCTC
GCCCACGCGGACGCGCTCGCGCCCGTCGTCGTCGAGGGCGAGCGCGCGACCGTCGCCAACGTCTCGGGCG
AGGTGTCCGTGCGCGTGGCCGCGGCGGACGCCGAGACCGAGGGCGTCTACACGTGGCGCGTGCTGTCCGC
CAACGGCACCGAGGTCCGGAGCGCCAACGTCTCGCTCCTCCTGTACAGCCAGCCCGAGTTCGGCCTGAGC
GCGCCGCCCGTCCTCTTCGGTGAGCCCTTCCGGGCGGTGTGCGTCGTCCGCGACTACTACCCGCGGCGCA
GCGTGCGCCTGCGCTGGTTCGCGGACGAGCACCCGGTGGACGCCGCCTTCGTGACCAACAGCACCGTGGC
CGACGAGCTCGGGCGCCGCACGCGCGTCTCCGTGGTGAACGTGACGCGCGCGGACGTCCCGGGCCTCGCG
GCCGCGGACGCCGCGGACGCGCTCGCGCCGAGCCTGCGCTGCGAGGCCGTGTGGTACCGCGACAGCGTGG
CCTCGCAGCGCTTCTCCGAGGCCCTGCGCCCCCACGTCTACCACCCGGCGGCGGTCTCGGTGCGCTTCGT
CGAGGGCTTCGCCGTCTGCGACGGCCTCTGCGTGCCCCCGGAGGCGCGCCTCGCCTGGTCCGACCACGCC
GCCGACACCGTCTACCACCTCGGCGCCTGCGCGGAGCACCCCGGCCTGCTCAACGTGCGGAGCGCCCGCC
CGCTGTCGGACCTCGACGGGCCCGTCGACTACACCTGCCGCCTCGAGGGCCTGCCCTCGCAGCTGCCCGT
CTTCGAGGACACGCAGCGCTACGACGCCTCCCCCGCGTCCGTGAGCTGGCCCGTCGTGAGCAGCATGATC
GTCGTCATCGCCGGCATCGGGATCCTGGCCATCGTGCTGGTCATCATGGCGACGTGCGTCTACTACCGCC
GGGCGGGGCCGTGACGCCCCGCGCGTTCCCCCCCCACGTCGAATCAATAA

Protein Information

Protein Name

envelope glycoprotein C

NCBI Protein GI

51557513

Protein Accession

YP_068347

Protein pI

6.98

Protein Weight

45878.36

Protein Length

479

Protein Note

envelope glycoprotein C; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA;virion envelope glycoproteins bind to cellular receptors; the nonessential glycoprotein gC interacts with cell surface proteoglycans, whereas the essential glycoprotein gD is involved in stable secondary attachment

Protein Sequence

>YP_068347.1 envelope glycoprotein C [Suid alphaherpesvirus 1]
MASLARAMLALLALYAAAIAAAPSTTTALDTTPNGGGGGNSSEGELSPSPPPTPAPASPEAGAVSTPPVP
PPSVSRRKPPRNNNRTRVHGDKATAHGRKRIVCRERLFSARVGDAVSFGCAVFPRAGETFEVRFYRRGRF
RSPDADPEYFDEPPRPELPRERLLFSSANASLAHADALAPVVVEGERATVANVSGEVSVRVAAADAETEG
VYTWRVLSANGTEVRSANVSLLLYSQPEFGLSAPPVLFGEPFRAVCVVRDYYPRRSVRLRWFADEHPVDA
AFVTNSTVADELGRRTRVSVVNVTRADVPGLAAADAADALAPSLRCEAVWYRDSVASQRFSEALRPHVYH
PAAVSVRFVEGFAVCDGLCVPPEARLAWSDHAADTVYHLGACAEHPGLLNVRSARPLSDLDGPVDYTCRL
EGLPSQLPVFEDTQRYDASPASVSWPVVSSMIVVIAGIGILAIVLVIMATCVYYRRAGP

Vaxign Prediction

Localization(Probability)

(Prob.=0)

Adhesin Probability

0.276

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope