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MLANA

General Information
Protegen ID 706
Sequence Strain (Species/Organism) Homo sapiens
Taxonomy ID 9606
Molecule Role Protective antigen
Molecule Role Annotation a recombinant adenovirus vector encoding the melanoma-associated antigen, MART-1, was used to transduce murine DCs, which were then tested for their ability to activate cytotoxic T lymphocytes (CTLs) and induce protective immunity against B16 melanoma tumor cells implanted intracranially. Using the B16 murine melanoma, which naturally expresses the MART-1 antigen, all the mice were then challenged intracranially with viable, unmodified syngeneic B16 tumor cells 7 days later. Splenocytes obtained from representative animals in each group were harvested for standard cytotoxicity and enzyme-linked immunospot assays. The remaining mice were followed for survival. Immunization of C57BL/6 mice with DCs transduced with AdVMART1-DC elicited the development of antigenspecific CTL responses. As evidenced by a prolonged survival curve when compared with control-immunized mice harboring intracranial B16 tumors, AdMART1-DC vaccination was able to elicit partial protection against central nervous system (CNS) tumor challenge in vivo (Broder et al., 2000).
Related Vaccines(s) 27-35(27L):MART-1 peptide vaccine , Adenovirus Encoding Tyrosinase/MART-1/MAGEA6-transduced Autologous Dendritic Cell Vaccine , Allogeneic Large Multivalent Immunogen Melanoma Vaccine LP2307 , Alpha-type-1 Polarized Dendritic Cells , ALVAC-MART-1 Vaccine , Autologous Anti-MART-1 F5 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes , Autologous Dendritic Cell-Allogeneic Melanoma Tumor Cell Lysate Vaccine , Autologous Lymphoma Cell/Allogeneic Dendritic Cell Electrofusion Hybrid Vaccine , Autologous-Cell Leukemia Vaccine , Dendritic Cell-gp100-MART-1 Antigen Vaccine , Dendritic Cell-MART-1 Peptide Vaccine , Gag:267-274 Peptide Vaccine , gp100-Reactive Autologous Peripheral Blood Lymphocyte Vaccine , HLA-A2-Binding TYR/MART-1/gp100 Multipeptide-Pulsed Autologous Dendritic Cell Vaccine , MART-1/gp100/Tyrosinase/MAGE-A3 Peptides-loaded Irradiated Allogeneic Plasmacytoid Dendritic Cells Vaccine , MART-1:26-35(27L) Peptide Vaccine , MART-1:27-35 Peptide Vaccine , Melan-A VLP Vaccine , Melan-A/MAGE-3.DP4 Peptide Vaccine , Multivalent immunotherapeutic vaccine , NA17.A2 Peptide Vaccine , NY-ESO-1(157-165) Peptide-pulsed Autologous Dendritic Cell Vaccine , NY-ESO-1/MART-1 Peptide-pulsed Dendritic Cell Vaccine
References
Broder et al., 2000: Broder H, Anderson A, Odesa SK, Kremen TJ, Liau LM. Recombinant adenovirus-transduced dendritic cell immunization in a murine model of central nervous system tumor. Neurosurgical focus. 2000; 9(6); e6. [PubMed: 16817689].
Gene Information
Gene Name MLANA
NCBI Gene ID 2315
Genbank Accession AL365360
Chromosome No 9
Locus Tag RP11-546N22.1
Gene Starting Position 5890908
Gene Ending Position 5909821
DNA Sequence 
>NC_000009.12:5890908-5909821 Homo sapiens chromosome 9, GRCh38.p12 Primary Assembly
CAGCAGACAGAGGACTCTCATTAAGGAAGGTAAGAGCGTTGCCTTCTCGCCATAATCATAGTCCTCTTCT
CCCAGAATAGGATTTGGGAAATTCTGGCTAAGTCCTCTGCCTACCCTCATTGCCCCGCTGATGTGTGACA
TCAACAGAATTTCTCCGCAACGTTTGTCAGTCTCCAACCTCAGAGGGCTCACAAAGCCTCCTCCTGAATC
CTCTCTCAGTCCTCCAACACTACCAAGAAGAAAAGCAATTATTCAGGATGGCATCTTGCTGGGGAGAAGC
AGCCTCCCTGAGGTAGATGTGTTCTCCTGTCACTTAAAGAACCACTTCTCCTGGTCTGAGTAGTAAGAGG
CGCATTTGCTGTTGCTGCACCATTTGCCAAGGCTCTGAGTTTGAGGTATGGGATGTATTAAAACAATTTA
ATGAAGAATTAAGATTCCATTCTGTCATTTTGAACACAGGGTTCAGTCCTATATTATTCACTTGAGAGGA
CTGGTGAGTTTGACTTTCATTTCTTTTTTACAACTGGGAAGGGCAAATTACACATAAAATGTCCCAGTGG
AAAGGGGTCATGTGTCGAAATCCCCACTCTTCTGTCTCACCTCTCCCTGTTGTTTTAAACTGGGGCTCAT
TAATATAATTCTATGGGGATCACACCTTTGAAATTCATGAGGACAGTAAGAGAGCAGAAAAATACACAAT
AATAAGGAAAGGAGCTTCCATTATTGGTTTTTAATGAGCGTACTTGAATTACGGCCACTGCAGTTTATGG
ATATTTTTTGTTGTTCATTTGTATGTGTTATAGTTAGAAAAAAAAAGAATCCTAGCCAAGGGACTTGAAC
CAGAGAGAAGCAGAAATTGACTTAAGTAGGAAGGGAAACACATTGTTAGATAAAGTCAGGTCCTGGGCTT
CCTCGGCTTGTTTTGGGTGGAGTGCCTGGGGACAGGCTGAAGCCCCTGTGTGGGGTGGTTTCCTTTGCTG
AAAAGCTGGGCTGGAAGATGTTGTGCTCAGTGCTCAACCTCATGCACCCTCGCGAGGCACAGGCAACGGG
TGCTCTGGGAAACACACGTTATGTATCATAGCCTCTGTTTGTCTGTGGGATTGATATCCAACAATAACTT
TGGAGAAAAATAACTCCTCTAATTTTGTTAGCCACAGCCCTGGGCCAGGGAAGGTGGAGAATCAGTGAAA
ATGCATTTTGTTTGTTTCTCTAGAAGTTTATGGTGCAGAGTCAAATTGAAGGCAAATGAGGAATATTTTT
TCACCAAATAATAACTCAACTTGCAAGTCTTTTTTGCTTTTGTTTGTAGTTTCTTCTTTGAACTTAATTT
TCAGTTAGTAGGAGGGGTTAGAAACCTGAGCTATTGCTAAAGCCCTTGATATGAATGAAAGAAGCAGGTG
CAAATCCCCTCACAGAGAGAAACCAAAGGGTCCTGGCTATGGATATTGGTCACCTAGTGAGGATGCTGTT
GTGGGTCTTTATGAGATGATGAATAGGGTGGCTTTGGATGCATTAATGATGCCCACATGCTCCTTCTGTT
AGGTGTCCTGTGCCCTGACCCTACAAGATGCCAAGAGAAGATGCTCACTTCATCTATGGTTACCCCAAGA
AGGGGCACGGCCACTCTTACACCACGGCTGAAGAGTAAGTTCAAAACCAGACCCAGCAGGGCTTCCAGTT
TGCCGTTTGCTGACACAGCCTGCTGACTTCCACCAGTACATGCCTGCTCGTAAATCTCCCTAGTGTTTAT
CTCCCCAGACAGTAACATCCCTGGCAACAAGGGGAGGAGATTCTGTGCTTCTATAAGGGGCTCAGTCAAG
CTTCTCTGAGGCCAAACAGGCAGGAAGATGGGAATGGTATAAGGTTGGATCTTGCCATTTTTGGGTGCAC
TTTTGACTATTGGGTCTTATCTGTAGGTTCCCAAGTGGAAAAACATCTGTTCAGGATCACAATGCCTCTC
TCCTCAATCCTTGTTCTGTCTCCTCCACTCAAATTCCTGAAGGTGGTTTGCAGACAGAATAAAAGTGAGT
TGCCAAGGAGCCAGTAAGGATGACGGGCAGGTGTGTGTGACTCAGCCCACAGCCAGACTCGAGAGGAAGA
TGGAGGTCACAGCCTTTGCAGTATAACTTTATCCTAAGGAAAGACATTGGGTTTTATGAGTGAATTAAAA
ATAAGTATTTATATGATTAAGCATTTCTAAATGCTAAGCATTGTATACTGGCGTGAGACACTGTTTTTAT
CTTTGAAAAAACTCACAACTTAGTGGGAGAGTTAGGCATGAGATTAATTTCAGCAAATGTAAGTGCGGTA
ATGAAAACCCAGAGGCTGCAGGGACATACTCTGTATGTGCTGGGAGTGGGAAAGGGACATACTCTGTACG
TGCTGGGTGGCAGGGGCAGGGGAGGCCCCACCCTCTGCGTGGGACTCTAACAGGACAACACCCTCTTATG
TGGTCTGTCCAGAACTCCCTGTGAACCTGCTCTTTCTTTGGAAAGAGCTGTTGAACAATCTTTGTTAACA
GTCAACCGCAGGGACCAGCAAGATGTAAAGCCCAACAAAGGCACTGAGGAAGAGTTCAGGCAGACAGCAT
TTCCTCAGAAGACCCTGGTATAGGATCCTCTAATATCCCTGGCCAATTGGAGATGAGGGCGGCGGTATCT
TCTCAGAAAATGTCCTGACAGCAAAAACATACTCTTTGAGGGAGGGGAGCCCATTGCCCGTGCTATTAGT
TAGGGTATCGTTTCAGCTTGTGTATAATCACTCAACAGACTCTTTAAAATATACTTTTATGTCTCGTGTA
AAAATTCAAGAGTAAAGAGTTCAAGGCCTGTTCGTTTTCTTCTTGCTGGTTACTCCCTTGGGATGTCACT
TTTGTCCCCATGGCTGAAGATGTTGTGCCATCACCTCCACATCTTGCCAACAGAAAGCAGGAGGTGAAGG
AGAGGCTAGGACCGTTCCTTTCAAGGGGCACACGTCACTTCTGCTTATTGCTCCACCCCCGCCCCCCGCC
CCGTGGCACCCACCCTGGTGGGTATCATTCTTGCTGTGTTGTAAATGAAGAAAGGTTTAGAGAAATTAGG
AAATGTGTGGCCAGACATGGTGGCGCTGGGATTTAAATCCAGGTCTGTTTGCCTCCAGAGTCCATGCTCT
TAAGTGTTATGCTGCAGGCCAGCAGAGGCAAATATTTGCACAATCCCATCCGACGAGAGGCTAGGGCAGA
GGTCAGTATCTCTCAGTGTGAAGCTGGAGGCTGATGCTAGTCAGCTCAGTAGGCCGAAAGTGGAGTTGTC
CTTTGCCATGTAGGGCCATCATGCCCAGCTGGGGAACCTCATAGCCAGGTGTACCCACAACCTGAACAAG
GTAACTTTCAGGGTCTAGTCAGGAAGAAACCAACTAGATGGTTCAACATAGAGACTTTAATATAAGAAGC
TGGTTAAACAGGCATGGGACTGAGACTGAGGAGGCAAAGAAGGCATCGGGGCAACCAAGGCTGTACCCAC
AGAATGCTGCTTCTACCCCCGTGTCTGGGGTAACAAACGGAAGGGTGAGGCCATCAGGACCTAGAGTTGG
GAGGAGGGACGCCACAGAAATGGGACCCAGATCTCTAAGGAGAGATTTTTGTTTGGCTGGTTCTGGTGTC
TCAAGAGCTTAGAAGTGAGGGGCATGAATCAAATACTCAGGCCTCTGAGGTCAGCCAGTGCTCTGCTGGG
GAGGGGCATAATGAAGCTGGCTCTGACAATGCCGGAAAACGAGCTGGTGCTTGGCATATACAGACAATGT
GAGCATTGCTGGGGTGATCCTGACAGGAGCCAGAAGCACACTGGAAGGAGCTGCTCCTTCTTGATGCCCC
AGGTTTGTAGGCACCCTCTAGAGTACTCTAATGGGAGCCAGTGGGCAAAGGAGAAGTGGCATTTGCAGAG
TCCAGTCCCAGCATCACAGAGCAGAGCATAGAAAGGTAGGTTTGGAGTTGAGGGACAATGGCTTAATAAA
GGGCAAAGGGGGTTATGACCACTATCATGTGAAGGAACCCCTTGACTGAAGGCACAAGCTTTCTGTGTCT
TGCAACCTGAATGACGTGCATAAGCAGGGTCAGGTGGGTTATCTGACATTTTCCTTGAGAACAAGAGGGA
GCCTCTGGATTCCAGCACAAAAGAAAAATACCCACTCAACCCGTATGCGTGGGAGCTATCCTTTAAAGAG
AAAGTAATTCCTTTTGACATTTTGCTGTCTGTAGAAGGGTCAGATGGCCAAAGCTTCCAGCACAATGAAA
CACTTAACTTCAGTCTGTGAGTGTAGGAACCCCTGAATACATGGAACATCATCATCTTGTGCAGGTACTG
AAGGAGATCGGTCCAGAAAATAAGTAACTGCACATGGCCACCAATGTCAAAAGTCATTCCTCTCATGAAA
AGTCCCTGCCCCCATTGCTGTTTGTTTAAATAGGTGGGATGGAGGTAGGGGAATGGGGCCATCTTCTTTT
TTTTTTTTTAATTTTTTTGCATAAAATCCAGATCCTGCACAATGGGGCAATCTTCATTAAAACAATGCAT
CCCTAAGATCTGAGAATATTTATCCTTCTCACAATTGTGCCAGCAGGTGGAATGAAGAAGAATGATGCAA
AATAAGTTCCCACATCCAGCCAAGAAGGACTACATACCTGCTTTGGGTATTATGTATCTCTTTGAAACCT
CAGTGGAGAGCAGTTCTCACAGTTGGGTGGACACAAGTCATCCATGGAACTTGTTAAAATGCAGATTTCT
AGGTGCTGCCACCTAAGAGGCTGATTGGGTAGGCCAGGGGTGGAGTCCTATGATCTGCACCTTAACGTGC
ATCTCAGGTGATTCTGCTGCAGGTGGTATTTGGAAGACACTCTGAGGCGCCCTGCCAAGCTGGGCAGTGG
GTTCTTCCAATGTGTCAGGCATACCCTGGTGCTTTTCGCTCTCAGTTACTTGGGCATGTTGTGAGTACCA
CGTGACCATGCATAAAGTGCTGTAACAGAGCTCTGACTGTGTCAAGATATTCAAGTGGACGCCACAGGGT
AAAATGAGAGCACAGGCATGTTGGGAGTTGAATCAGCTGCCTTCAGTCACGAGAACACACTGAACACTCC
TTGTGACAGCTTCAGTTCAGGAAAGAGTGACTCTGCAGGAAAAGCACTGGCCTGGGAGACCTGGATCTGG
CCCAAATTCTGGTGCTCACTTGCTTGGTCTCCCGTTCCAGTTGCTGTGAATGTTGGTTCTGCCACTTGCT
GGTTGTGCAGCCCTGGGCACTTGACCAGCATAATGTCAGCTGTAAAATGAACATCATTCCTAACTCCGAG
GACTGTGGTTAGGATGAAATAAAAGCATATATGTGGGGGTGCCTAGCCCAGTGCCTGGCACAAATTGGTG
CTCAATGAATGGTAGTCACTATGGTTATGGTAATGTTGATGAATCTTCATAGGTCTCAGCTTCCTGATCT
ATAAAGCGGGTGGACTGACCTACATAAGTCAGAGTTTCCATCTAGCACTGTCATCCCATGGTTCGCTCTA
TCCTGTTTGGAGACGGACAGGATAAGCTTGATGTCTCCTCAGCCTTGAGACAGAAGTTGTCCAGTAGATG
GTACTGAGCAAAAGTCTCTCCAGCAGAAGCCTTAGTTAAACCTTGCTTCTCCTGTAGCTGCTCAGTCTCT
TGTAAGTCACTCAGCTCTGCAGAAACTTTCTTAGCGAGTTGACAACCACAGATAACAGAGTCAGTTCTGT
CGATTTTGATCATGCTGTGATCAGGCAGATGTTAGCTAATTGATGATGCTTGCCCGGAGTGAACAGCTCC
AGGCCCTGTTTCCAGGGTCTTTGTGGTAACTTTGTGGTAACTGTAATGCTTCCCAGGGGTCACTGAACAC
AGGGCCCAAGAGGCTGGTGTAGACCCCCAGATTGGCACCCTGCTGCTTAGACAAGATCCTTCTCAATAAG
TAATGCCACAGCTTTGCTGTAGGTTCAGCCCAGACACTTCTCCCTAGGGCTGCAAGGAGCAAAGCGGGGA
GTTTAGGGAAGGGAGGGCACGAACATAATTGAGACGGATTCAGGTTCAAATCCAGCCTCTGTTTTGTGCT
AGCTCTGTATGATCACCAGCGAGTCATGTATCCTCTGCCTTTTATTTCCTCTTCTGTGAAAATAGGGGAT
GATAAATTGTGTCTACCCTCCAGTGTTGATGTGAGAATTGAATAAGCTAATGAATGTTTAGCACAGCACC
TGGCTTTTAGTAGATGAGTCAGTGTTAATTTCTATTTTCTCTTTGTGGGCTGAGTTGGAGAAAATGTTTT
AAAACAGCCTGATGAGAAGAAAAGATAATTTAGCCCCAATAAATACATTGTCCACATAAAGACCAGTTAC
TATGGCACTTCTCATACCTGGAACTTGGGTGCCTGGGCCATGCCAATTAGCAGAGTTCCTGTGGGCACAC
ACTTGAGAGGCTCCTAAAGACCTGGGTTAGATCCAGGTGCTGGAGGCCTGGTGGGGTGCCCAGTGTGGGA
GGTGGGAAACTACTTGGACACTGGGAGATGCTGCTCTGGGTCGTCAAAGTCCATATGAAGAGGAAGACTG
ATTTATGCTTCATCATAATGTAGAACAATGTTTCAATGACAAAGTGGATTTGTCTATCTCTTGGGCCAGG
GCCGCTGGGATCGGCATCCTGACAGTGATCCTGGGAGTCTTACTGCTCATCGGCTGTTGGTATTGTAGAA
GACGAAATGGATACAGAGCCTTGATGGTTGGTAAAGTTCCCACTGCTGAAATCCCTCCAAGTCCAGGGCC
CTCTTTCCAGTTCTTTCCTCTGAATCTCTGGAGAGTCAGATAATTGCCTCATTATAACCTTCAGCTCTGA
TTCCGGCTTCTGATGCCTCTTTTGCTACATTGTACTTTGGCAACTCTACCTTTGCCTCTGCTCAGGCATG
AACCTCAACCAGGAACTTGCCCTGTGTCTTAGTCTGTGATTATAACATAATACGAGAGACTGTAATTTAT
AAATAAATGAAATTCATTTGGTTTACAGTTGGGAGGCTGGGAACTCCAAGATCTAGGGGCCACACCTGGT
GAGGACTTCTTGCTGTGTCATATCATAGTGGAAGGCATCACATGGGCAAGGGAGTGAGAGAGCAAGAGGG
AGCTGAACTCATTTTTTTTTTTTCTTGAAACAGGAAATCCTGGGATGGAGCGCAGTGGTGAACATGAGTC
ACTGTAGCCTTGACCTCCTGGGCTCAAGCCATCCTCCTGTCTCAGCCTCCAGAGTAGCTGGGACCACAGG
CACGTGCCACCACACCGGCTAATTAAAAAAAAACTTTTTTTTGTAGAGACGAGGTCCCACTATGTTGCCC
AGGCTGGTCTCAAACTCCTGGGCTAAAGTGATCCTGCCTCGGCCTCCCAAAGTGTTGGGACTACAAGTGT
GAAACACTCCACATATGGCCCAAACTCACTTTTATAACCAACCTACTTTTGCAATAACAAACACACTCCT
GCAATAACAACATTAATCCATTCATGAGGACAGAGCCCTTGTAACTTAATCACCTCTTAAAAGTCCTACC
TCTTACCATTGTTGCATTGGGGATTAAGTTTCCAATACACGAATTTTGGGGGACACATTCAAACTATAGC
ACCTGTCTCTTTGGTTCTACTCATAGCAGACTTGGGTACCTGGATGTTGTGTGTAGCTAAGCACTGACGG
TTTATAGGGCACAGGGGAAGGGGTTTGAGGTTCCCTTATAGCAAACAGGAGTATATTAGACACCTCAGGT
TTTACCACTTCTGGGAATTCTTGCTGGTTCTGTTACTCCACTTTGTGACCTGCTCTTCCTACTTTTCTTC
TTCACCCCTTTCCTCACTGGTTACCTGTGAATTCCAAGTTCTTCTGACTCTACACTAAGCATCCCAGGAT
ATCATCAGTGCGATGAGGAAACCATCCTTCCTGCATCAGCACAAAGGGTCACTTGTGTGTTTTTTAACAG
GCTGCATCCTTCTTAGATGGCCAAAGGTTTTAATAGTATTTTTTTCTTCTTTACCCAAATATGCAGGAAG
CTAACACAATTACACAATCCAATCTTCTGGTACCAGTATCCTCCATGAATGGGAAACATCAACTGAGTTT
ATAAGCTATAAAAATTACAGGTTTCAGCAATCTTGCTTAAAGCCAGGTAGCACTTCAGCACTTCAGCACC
CGAAGGCATTCTCCATAGATCTCGCTGTCTCTCTTTCTTGTTATTACAGATCTGAAAGCTTTTCAGGTTG
ATGCATAATGGAAAAAAAGTATCTTTCCAAAAGATGTTGGAAAGTCCCATTCCTCATTCAGCAAGCACTT
CATTTAGAGGAAAAGGTCCTGTGAAAGAGAGGAGGGTTGGTGTGGGGTGGGGATTGAAGCTTGGCAAGCT
GATAAGGAGAAGGTGAGAGATACAACTCTGGATTCTTTCCCTCTTTGCCAAGAAACTTGGGCAGTCTCAT
GTCTCATGTCTCCTGTTCCCCAATGTCTTTCCAGAGCATAAATACAAATACAAACCATCAAAGGCAAGTC
AAGTCTGGGGGCTGACACACCCACCGAGCATAGCCCTCTAGTGTGCTGACATCTAGTGGGAAGGAGGAGG
AGTTGATGAATCTGAACAAGACTCCAATATTGGAGGAAATACTTGAGGAAAGCCTTGGGTTAGAAAGTTA
GGGATAGAATTCCTGCTCATACGGCTGTCCACAACAGGTTAGTAGGGGAGGACTTTAATCTCTGCCATAG
AACTCCATTTGTAACTCTAGCATGGGGTTATGACATTGCCTTGTAATTGGCTATTTACTTTTTGCCTCTT
CGACCCCTCCGCTTTCCCCTATGTATGAACCACAACAGAGAATATTTCTAACTCATCTTCATATCTCCAG
TGCCTAGCACAGTGCCTGGCACATGGTAGTCACTCAATTGTGTTGCATTAGGACTTGGTCCCATTGTCTG
CCATTGAGTTGCTTGGAGACTAGAATTCAACTTCTCCAAGATTCACTAGCTCTATTTTACACCCAGACAT
GTTGGAAATCTGTGATGTAACACAATGTATATCCATTTTTATTTAATACATATTTTCTTCTATATTTTGA
TTTCATTATATATTTGTATATCAAAAACAAAATGTTTAGTCTTTCAAGAAGTAAAGCTATACAAACTCAA
TATGTTGGTACTCATTTCCTAACTATAATTATTAGTTTGATCCTATTGAACACAAATGCAGTAATTTTTC
TTTTCTGCTTCAATGCTCTCATCTTAAATTCATTTAATTGAAAAATAACAGAGAGTCTTAATGTCATGTG
CTCAGACACTGTGAACATTTTGCTTGGTAAGTTTCAAATTCAAACTCTATGCCTCCATTCCTCTAGGATT
AGATCAGTGGTTTGTAGTTTCTGAGACTTTTTATTGAGAGGGAATCGTGTTTAAATTTCCTGGTTTATTT
AATTTCCATATTTATTTTTTAAATTAATATTAAAATCTTATTTTGAGATTTTCATATATCTAGAAAAGTC
AGTTTGGAGATCAGCAGTCTAATAAGTTTAGGCAAAATTATGTAAAATAGTGCATTAAGTATTGCATTTA
ATTACATAATTACCTCCCTTTCTGTCTTCAGTGATTCTATTTTCATTTTAAAGCAAAGGGATGTAAATGA
CATTAAATATGAGCTTTGGGCATGTGAATTACTCCACCTTTAACAATCTTCATTAAGCTTGAAATGTCTA
CTTTTCAACTTCCATTTGTCCACAGAGAGGCTGGTTGGAATTTAGATCTCTTAAAATTTCTCCCTTGGTT
AACAATTCCCCTGAGCCCTGGAAAACATCTTTTGAAAGGAAAGGCTGCTTTTTGTAGCAACAGGAAGTGG
GAAATGATTTGTAATAAACTGAACAGTGGTTTTTATATTAACCAGTTTTACATCTTCACTTGGAAGTTCA
AGGACAAAATACTTTTGATTCTTGGAGAATTTCATGGCCCTTGCTCTCAGCTCAGTTTACACTCATGTGT
CAGGGCACTGTGTTTTTCAATGCATGGTCAGTGGTCACCTGCACTGGAATACTTTGGGGTTCTTGCTAAA
AGGCAGATTCTGGGATCATCTCTGGTGGTGGGATTCAGGAATCTATATTTTAAAATGTACACCCAGTTTT
AATGTAAATACAGAGAACTGGCAGTGAACCGGTAGAGTGGATCATACTCTTAACCTATGGTGAGTGAGAG
GCTTAAAAAAAAAAGAAAAAGAAAAAAATGGTAATTGACAAGGGCAGTTTTATTTTTTTTTCCCAATCAG
TACACCTTTTATATCCTTTTCCAGTTTATTGCATTAGTTATTTGCAACTTCCAGTATGATGCTGAAAAGG
AGTGGTGAGACAGGACATCCTTGCCTTGTTCCTGATCTTAGCAGAAAAGCTTCAAGTATGATGTTAACTG
TTGATTTTTTGTACCTAGATATTCTTCAGCAAACTTGAGTAAGTTTCCCTTTATCCCTCGTTTATTGAGA
GTTTTAAATTATGAATGGGTGTTTGATTTTGTCAAATGCTTTTTCTACATCTATTGATACAATCTTGCAA
ATTTCTTCTTTAGTCTATTGATGTATCAGAATAATTCATTTCTCTTTTTCTTTTTTTTTGAGATGGGGTC
TCATTCTGTCACCCAGGCTGGAGTGCAGTGGCTCAATCTCAGCTTACTGTAACCTTCACCTCCCAGGCTC
AGGTGATCCTCCCACCCCAGCCTTCCAAGTAGCTGGGACCACAGGTGTAAGCCACCACGCCTGGCTAAAT
TTTTTTGTATTTTCGGTAGAGATGGGGTTTCACCATGTTGCCCAGGCTGGTCTCAAACTCCTGAGCACAA
GCAATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCTGGCCTGATTT
CTCAATATTGAACCAGGTTTGCATACCTGGCATAAATCCTATTTTGTCATGGTATGTAATTCCTTTTATA
CATTGTTAGTTTGACTTGCTAATATTTTGTTGAGATTTTTTGCATCTGTATTCATGAGTGATATTGAGCT
GTAGTTTTCTCTTTTTGCAATATCTGTCTGGTATTAGGGTAATGCTGGCCTCATAGCAATGAGTTACAAA
GTATTCCCTTTGCTTCTATCTTCTGAAAGAGGTTATAGAGAATTGGTATAATATCTTTCTTAAATGTTTG
GTAGAACTCACCACTGAACTCATCTGGGTCTGGTGCTTTCTGTTTTGGAAAGTTATTATTGATTCAATTT
TTATAATAGATATAAATCTCTTCAGATGGTCTAGTTCTTCTTGCGTGGATTTTGACAGATTGTGTCTTTC
AAAGAATTGTTACATTCACCTAGGTTTTCAAATTTGTGAGCATAGTTCATAGTATTCCTTGCTTATCCTT
TTCATGTCCATTATTATTTCTGATAATAGTAGTTTGTGCCTTTTTATTTCTTAGCCTAGCTAAAGGCTTA
TCAATTTTATTGATCTTTTCCCAGAATCAGCATTTGGTTTCATTGATTTACTCTACTGACTTTTTTTTCT
TTCTTTCTTTCCTTTTTTTTTTCTAGAGACAGGGTCTCATTCTGTCATCCAGACTGGAGTGCAGTGGCAC
AATCATAGCTCACTGTTACCTTGAACTCCTGGGCTCAAGCACTCCAATCCTCCTGGCTCAGCCTCCTGAG
TAGCTAGGACTACAGCTAGCTACCATAGTAGCTAGGATTATAGCATGTGCCTCCAGGTCTGATTAATTTT
CTTTTTTTTTTTTTTAATTTGTAGAGACAGAGTCTCACTATGTTGCTCTGGTTGGTCTCAAACTCCTGGC
TTCAAGCAGTCCTCCTGCCTTGCCCTCCCAAAGTACTGGCATTATAGGCATGAGCCATTGTGCTCTGCTG
ATTTCTTGTTTTCAATTTCATTGATTTCTGCTCTAATTTTTATTTTTCCGCTTACTTTGGATTTAATTTG
CTGTTCTCTTTATTTTCCTAAGGTGAAAGCTTAGATGACTGATTTTAGATCTTTCTTCTTCTCTAATATA
CACATTCAATGTCATACATTTCCCTCTAAATACTGCTTGCACTGCTAAGCAGTATCCCACAAATTCTGAT
ATCATATTTTAATTTCATTTAATTCAAAATATATTTAAATTTCTCCTGAGATTTCTCCTTTGACTCATGT
GTTATGTAGAAGTGTGTTGTTTAATCTCCAAGTGTTGGGAATTTTTCAGTTATCTTTCTGTATTGATTTC
TGCTTTAATTCTATTATAGTCTAAGTGCAAACATGGTATAATTTCTATTCTTTTAAATTTGTTAAGATGT
GTTTTGTGGCCCAGAATGTGGTTTATCCTGGTTAATGTTCTGAGCTTGAGAAGAAAGTGTATTCTGTTGT
CGTTGGATGAAGTAGCCTACAGATGTCTATTATATCTAGTTAATCGAAGATTTTGTTGAGTTCCACTCTG
TCACAGTATATAATTCCTTTTATATATTGTTAGGTTTGATTTGCTAATATGTTGTTGAGTTTTTTTGCAT
CTATATTTATGAGAGATAACGAATTGTCATTTTCTTTTCTTGTAATATCTTTGTTTTTGATATTAGGGTA
ATGTTGGCCTCATACAATGAGTTAGTCCTTACTGATTTTTTACCTGCTGGCTTTGTGTTATTTCTGATAG
AGAGATGTTGAAGCCTCCAACTGTAACTCCAACTTCATAGTGGATGCAACTATTTTTCCTTGCAGTTCTA
TCAGTTTTTATCTCATGTATTTTGATGCTGTGTTCTTAGGTACATGCAATGTTAGGTGTTCTTATGTCTT
CTTGGAGAATGAACACCTTTATCGTTATGTAATATCCCTCTTTATCCCTGATAACTTTCCTTGAAATCTC
CTTCTGAAACTAATATAGGAACTCCTACTTTCTTTTCATTAGTGTTAGCATGGTATATCTTTTTCTATGC
ACTTACTTTTTTTTTTTTGAGACAGAGTCTCGCTGTGTCACCTAGACTGGAGTGCAGTGGTGTGATCTCA
GCTCACTGCAACCTCCACTTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGTATTA
CAGGTGTGCGCCACCAAGCCTGGCTAAGTTTTGTATTTTTAGCAGAGATGGGGTTTCACCATGTTGCCCA
GGCTGGTCTTGAACTCCTGAGCTCAGGCAATCCGCCTGCCTTGGTCTCCCAAAGTGCTTGGGATTACAGG
TGTGAGCCACCATGCCTGGCCTCTATCCACTTACTTTTAATGTACATGTATGTGTCTTTATATTTAAAGA
GGGTTTCTTGTAGAGAACACATAGTTGGGTCTTGTTTGTTGATCCACTCTGACAATCTGTCTTTTAATTG
GTGCATTTAGACCATTGATATTCAAAGTAGTTATTGATATAGTTGGATTGATATCTACCATATTGTTACT
GTTTTCTACCTGTTGCCTCTGTTCTTTGTTTCTATTTTTGTCTTTACTCTTTTTCTGCCTTTTGTGATTT
TCACTGGACATTTTATATGATTCCATTTTCTCTCCTTTCTTGGCATATCAGTTATACTTTTTTCTTTTTG
AGACAGAATCTCACTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCAGCTCACTGCCACCTC
TGCCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGCCTCCTGAGTAGCTGAGATTAAAGGTGCATACTACT
ATGCTCATCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCATCATGTTGGCCAGGCTGGAACTCGACC
TCAAGTGATCCACCCACTTGGCCTCCCAAAGTGCTAGGATTACAGGCGTGAGCCACCGCGCCCAGTCCAG
TTACACTTCTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCCGTTGCCCAGGCTGGAGTGCAGTGGTATG
ATCTGGGCTCACTGCAAGCTCTGCCTCCTGGGTTCATGCCATTCTCCTGACTCAGCCTCCCAAGTAGCTG
GGACTACAGGTGCCCGCTACCATGCCTGGCTAATTTTTTGTATTTATAGTAGAGATGTCATTTCACTGTG
TTAGCCAGGATGGTCTCAATCTCCTGACCTCGTGATCCACACGCCTTGACCTCCCAAAGTGCTGCGATTA
CAGGTGTGAGCCACCGTGCCCGGCCTTATACTTCTTTTTTACTTTTTTTCAGTGGTTTCCCTAGAGTTTG
CAACATACATTTACAACTAATTCAAATCCACTTTCAAATAACACTATACCATTTCATAGGCATTATGAGT
ATCTTAAAATAATCCTAATTCCTTCCTCCTGTAAACTAAAAACAAAATCCTAAATCCTCCAAACAACTGA
ATGGACCCCCTCTTCACCAAGGGGACCCCAGGGAAACCTGAAAAACTGAGTGTTGGCCATGACGGGAAGG
GAGGTGAGAGATGCCTCATTATACTCCCTCCCTTTTAGAGTTTTAGGTACAACTGACCAGCATTAATTTT
AAAATAGAGATTACAGGACTGACAGAATGAACTCTTTGTGGCAATATCAAATTAGGAACAAGACAATGCA
AGGAAAGGGTTAAATCATGCCCTTCAAACCATAAAAAAATTTTTTTTTAATTAACCCCATATAATGTGGT
ATACTTTCCAAACTGACTCTGGTATAGCATCACATGACAGATTGCAGACTCCCTTACCTTAAGCATTCCT
TTATACTGACTTCAAGTCTTAAGACAGAGCTGAACTCTTTCAACCAGCTGCTAACTAAAGAATACCTAAA
ACCCACCTGTGACTTGTAAGTCTCTGCTTTGCCATGTCCTGCCTTTTCAGGCTGACCCAATGTATACCTT
CCGTGTATTGATTTATGATTTTTACCTACAATTCCTGTCTTCCTGAAACATATAAAACCAAATCATAACC
CAACCACCTCAGGCACACTTTCTCAGGACCTCTTGAGACTATTCTCCCGGCCATGGTCATTCATATCGGC
ACAGAATAAACCTCTTTAAAATATTTTGCAGTTTTTTTCTTTCTGTTAACATTCCTTTCCCTTGTATCAT
TGCTGTTATTAATTTCAAGTATATATAAGCATACCTAATTAAATACATTGTTGCTATTATTCATTTTTGA
ACAAACTATTATCTGTTAAATCAACTAAGAATAAGACAAATATGTTGGGTGCAGTGGTGCATGCCTATAG
TCTCAGCTACTCAGAGGCTGAGGCAGGAGGATTGCTTGAGCTCAGGAGTTTAAGACCAGCCTAGGCAACT
TAGCAAGATCATGTCTCTTAAAAAAAAAAAAAGAAAGAAAGAAAAACAAAGTTTTAGGAGGCTGAGGCAG
GAGTATCACTTGAACCCAGGACGCAGAGGTTGCAGTGAGCCGAGATCGTGCCATTATACTCCAGCCTGGG
CAACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAGAAAAGAAAAGAAAAGAAAAAAAAAGTTTTTATTT
TACCTTCACTTATTCCTTCTTGGATGTTCTTCCTTTATGTAGGTACAAGGTTCTGACCTATGTTATTTTC
TTTTTCTCTAAAGAACTTCAAAAGTTTCCTGCAAGGCAGGTCTACTGGCAATGAATTCCCTCAATTTTTG
CTTGACAAAGTCTTTATTTCTGCTTCACTATTGATGGATAATTTCACAAGAGTGTTCCTTTTGTAGATTC
ACTCTTCTTATCCTTCCCTTCAGAAATATTCTTTGACCAACTATTGGGTCCCAGGTACTGCACTAGAGCT
TTACTTCTAGTTAATTCCCACAGCAATTCTGAGAGGTAGGTAGGTATTATATTCCTAGATGCAAACTCAG
AATTCAGAAGGTAAAGTGATGAGACTGAAGGCACACAGCAAGTAAGTGGCAGAACCTAGATTAAAACTCA
TTCTTAAAACTTTGGCTTCCTTCTCTTTTCTTTAATGGATTCAGTTACTTCTTCTCACCCACTCACCTTT
ATCAATTTACATTTCAGGATAAAAGTCTTCATGTTGGCACTCAATGTGCCTTAACAAGAAGATGCCCACA
AGAAGGGTTTGATCATCGGGACAGCAAAGTGTCTCTTCAAGAGAAAAACTGTGAACCTGTGGTAGGTTAA
GATCCTTCATAAGGGTATTTTCATGAATGGCTGTTTTTAACTCAAGTGAATACAATTATTTCCATTTAAA
AAGCAAGGACAATGTGAATGTACTCATTGCCACTGAACTATATACACCTAAAAATGGTTAAAATGGCAAC
TTTTATGTGTATTTTATGAGAATAAAAAATAAATAATAATAAAAAACAAGGGAAGTACAGATATTTTCTT
AATTGTGTTGTCACATACCCAGTGTTTCCAGGGTCAATAATGAGAGCCCTACATGTAAGATTCAAAGGAA
GAATTTAGTCCTGGATACAATATTCTTTTATGTTTTTAGTTATATTTGCCTTTTTAATGGATGCAGATAT
ATACAGAGGGAAGGGATAAAGTACCTATTATTTATTGTATAGAGCTGTGCTGTCTGATGGCTTAGCCACT
AGTCACATGGTGCTATTGAACACTTAAAACACAGGAGTTTGAAATAAGATGTATTATAATACATATCATA
TTTCAAAAATATTAGTATGTAGAAAAGAAGATAAATGGTTCATTAATGATTTTTATATTGATTCACCTTG
AAATAAATATTCTGAAAATATTAGGTTAAACAAAATATTTTAAGATTAATTTTACATGTTTCTTCTTTTA
AATGTAGCTACTAGAAATTTTAAAATTACATATGGCTGGGCATGGTGGCTCACACCTGTAATCCCAGCAC
TTCGGGAGGCCGAGGTGGGTGGATCACCTGATCTCAGGAGCTCGAGACCAGCCTGGCAAACATGGTGAAA
TCCTATCTTTACTAAAAATACAAAAATTAGCCAAGCGTGGTGGTGCATGCCTGTAATCCCAGCTACTTGG
GACGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATAGTGCCACTGC
ACTCCAGCCTGGGAGACAAGAGCAAAACTCCATCTCAAAAATAAATAAATAAAATAAAATTACATAAGTG
GCTTGTACCATATTTCTATTGGACAGCACTAGTACATATACAACACAGCATAATGGTTGAGAGCACTGAC
TCTGGAGCCAAATTACTGTGTTTGATTCTTAGCTCCACAACTTACTAGTTGTGTGACCATGGGCAAGCGA
GTTAACCTCTCTGTGCCCCAGTTTCCCATTCTGTAACATGAAAATAATAAAAACACTCCCAGAATTGTTG
TGAGCATTAAATGAAGCCCTGACACATTTGTTCTGGATACAATATCCTCTTGTTTTATATTTGGTAGTAT
CAATGTGCCTTTAGACACAATTACAACGATCTCTGTGGTAAAGATGCAATGTATATGGTGTCTATAAATA
GCATTCAATGATTCGTTAGTTAGGGCTTGAGACTTTTACTGTCATGGAAAATCTAGGTATAGCTAAGCTT
TTGAGATTTTGGGAACTCCTTAACCCTATTTTTCTCTACTCTTGCCCCCAACAATCAGCCTATATACTTG
TGAAATTTAACAATTACTTCACTGGGCAGAAATTATATGGGAACACTTAGAAATTTCAGTCCACAGGGAA
AGTATAAATATGTTAACTATTTTAACTTAATCCCTTCCTAGAAACACATACACTGTTGCCAAGCCCATAT
TCTCCCTTTCTTGTTCTCACAGGTTCCCAATGCTCCACCTGCTTATGAGAAACTCTCTGCAGAACAGTCA
CCACCACCTTATTCACCTTAAGAGCCAGCGAGACACCTGAGACATGCTGAAATTATTTCTCTCACACTTT
TGCTTGAATTTAATACAGACATCTAATGTTCTCCTTTGGAATGGTGTAGGAAAAATGCAAGCCATCTCTA
ATAATAAGTCAGTGTTAAAATTTTAGTAGGTCCGCTAGCAGTACTAATCATGTGAGGAAATGATGAGAAA
TATTAAATTGGGAAAACTCCATCAATAAATGTTGCAATGCATGATACTATCTGTGCCAGAGGTAATGTTA
GTAAATCCATGGTGTTATTTTCTGAGAGACAGAATTCAAGTGGGTATTCTGGGGCCATCCAATTTCTCTT
TACTTGAAATTTGGCTAATAACAAACTAGTCAGGTTTTCGAACCTTGACCGACATGAACTGTACACAGAA
TTGTTCCAGTACTATGGAGTGCTCACAAAGGATACTTTTACAGGTTAAGACAAAGGGTTGACTGGCCTAT
TTATCTGATCAAGAACATGTCAGCAATGTCTCTTTGTGCTCTAAAATTCTATTATACTACAATAATATAT
TGTAAAGATCCTATAGCTCTTTTTTTTTGAGATGGAGTTTCGCTTTTGTTGCCCAGGCTGGAGTGCAATG
GCGCGATCTTGGCTCACCATAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTTAGCCTCCTGAGT
AGCTGGGATTACAGGCGTGCGCCACTATGCCTGACTAATTTTGTAGTTTTAGTAGAGACGGGGTTTCTCC
ATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGG
AATTACAGGCGTGAGCCACCACGCCTGGCTGGATCCTATATCTTAGGTAAGACATATAACGCAGTCTAAT
TACATTTCACTTCAAGGCTCAATGCTATTCTAACTAATGACAAGTATTTTCTACTAAACCAGAAATTGGT
AGAAGGATTTAAATAAGTAAAAGCTACTATGTACTGCCTTAGTGCTGATGCCTGTGTACTGCCTTAAATG
TACCTATGGCAATTTAGCTCTCTTGGGTTCCCAAATCCCTCTCACAAGAATGTGCAGAAGAAATCATAAA
GGATCAGAGATTCT
Protein Information
Protein Name melan-A
NCBI Protein GI 5031913
Protein Accession NP_005502
Protein pI 8.21
Protein Weight 12561.33
Protein Length 118
Protein Note Also known as MART1; MART-1
Protein Sequence 
>NP_005502.1 melanoma antigen recognized by T-cells 1 [Homo sapiens]
MPREDAHFIYGYPKKGHGHSYTTAEEAAGIGILTVILGVLLLIGCWYCRRRNGYRALMDKSLHVGTQCAL
TRRCPQEGFDHRDSKVSLQEKNCEPVVPNAPPAYEKLSAEQSPPPYSP
Epitope Information
IEDB Linear Epitope