VIOLIN: Vaccine Investigation and Online Information Network

SMT

General Information

Protegen ID

745

Sequence Strain (Species/Organism)

Leishmania infantum

VO ID

VO_0011282

Taxonomy ID

435258

Other Database IDs

CDD:332925
CDD:332923
CDD:312111
GOA:A4IDL3
InterPro: IPR013216
InterPro: IPR013705
UniProtKB/TrEMBL: A4IDL3

Molecule Role

Protective antigen

Molecule Role Annotation

Upon challenge with L. infantum, C57BL/6 mice immunized with SMT formulated in MPL-SE adjuvant showed significantly lower parasite burdens in both spleens and livers compared with non-immunized mice or mice injected with adjuvant alone (Goto et al., 2007).

Related Vaccines(s)

L. infantum SMT Protein Vaccine

References

Goto et al., 2007: Goto Y, Bogatzki LY, Bertholet S, Coler RN, Reed SG. Protective immunization against visceral leishmaniasis using Leishmania sterol 24-c-methyltransferase formulated in adjuvant. Vaccine. 2007; 25(42); 7450-7458. [PubMed: 17804125].

Gene Information

Gene Name

SMT

Protein Information

Protein Name

putative sterol 24-c-methyltransferase

NCBI Protein GI

146104463

Protein pI

6.62

Protein Weight

38177.872

Protein Length

443

Protein Note

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; cl28104

Protein Sequence

>XP_001469832.1 putative sterol 24-c-methyltransferase [Leishmania infantum JPCM5]
MSAGGRETAPTNLIRRRNKDETNGDVSAAADRFRDRFEKATLEERKAATTTMVNEYYDLVTDFYEYGWGQ
NFHFAPRYAGETFFESLARHEYFLAARGGFMEGDHIVDVGCGVGGPARNMVRLTRCNVIGVNNNDYQISR
ARRHDALAGMSSKIDYVKTDFCNMSLADNTFDGAYAIEATCHAKDKVKCYSEVFRVIKPGTCFVLYEWCM
TDKYNPNDEYHRTIKHRIELGDGLPEMETCKQVIEYMKQAGFVVEEAIDVISQFESSPIKSIPWYQPLVG
DYSSLQGLRSTPIGRILTNVMCRVLEFVRLAPKGTYKATEILEEAAESLVVGGQLGIFTPSFYIRARKPS
KQA

Epitope Information

IEDB Linear Epitope