VIOLIN: Vaccine Investigation and Online Information Network

amastigote surface protein-2

General Information

Protegen ID

752

VO ID

VO_0011289

Taxonomy ID

5693

Other Database IDs

CDD:240366
CDD:271234

Molecule Role

Protective antigen

Molecule Role Annotation

To examine the efficacy of a new mode of recombinant viral vaccine, a vaccine was constructed of two non-transmissible Sendai viruses (rSeV/dF) encoding the full-length parasite antigen amastigote surface protein-2 (ASP2) or ASP2 fused with a mono-ubiquitin on its N-terminus (UASP2). C57BL/6 mice immunized intranasally with rSeV/dF expressing either ASP2 or UASP2 showed significantly suppressed parasitemia and could be protected from lethal T. cruzi challenge (Duan et al., 2009).

Related Vaccines(s)

T. cruzi DNA vaccine encoding ASP-2 , T. cruzi DNA vaccine encoding TSA-1, ASP-1, ASP-2 , T. cruzi DNA vaccine pUB-ASP-2 , T. cruzi Vaccine encoding ASP2 with Rapamycin , T. cruzi vaccine using Sendai virus vector expressing amastigote surface protein-2

References

Duan et al., 2009: Duan X, Yonemitsu Y, Chou B, Yoshida K, Tanaka S, Hasegawa M, Tetsutani K, Ishida H, Himeno K, Hisaeda H. Efficient protective immunity against Trypanosoma cruzi infection after nasal vaccination with recombinant Sendai virus vector expressing amastigote surface protein-2. Vaccine. 2009; 27(44); 6154-6159. [PubMed: 19712768].

Gene Information

Gene Name

amastigote surface protein-2

NCBI Gene ID

3537357

Protein Information

Protein Name

amastigote surface protein-2

NCBI Protein GI

284180153

Protein pI

6.84

Protein Weight

70196.77

Protein Length

785

Protein Note

ASP-2

Protein Sequence

>ADB82626.1 amastigote surface protein-2, partial [Trypanosoma cruzi]
MLSRVAAVKAPRTHNRHRVTGSSGRRREGRESEPQRPDMSWRAFTSAVLLLLLVIICCGSGAADAVEGKS
GAVQLPKWVDIFVPEKTHVLPKEGSESGVKKAFAAPSLVSAGGVMVAFAEGLFGHNVHGYDLFGIRPYEI
LAGYIKAAESWPSIVAEVNASTWRAHTVIGSRNGNDRLCFLYRPTAVARENKVFLLVGSDTVGYDSDDDM
WVKDGWDIQLVEGVATQSTDGKPSKTINWGEPKSLLKQVPKHTQDQLRDVVTAGGSGIVMQNNTFVFPLV
VNGKNYPFSSITYSTDNGNNWVFPESISPVGCLDPRITEWETGQILMIVDCGNGQSVYESRDMGKTWTEA
IGTLSGVWVKSRSGFRWDEGLRVDALITATIEGRKVMLYTQRGCASGEKEANALYLWVTDNNRTFHVGPV
AMDSAVNETLSNALLYSDGNLHLLKQRANEKGSALSLARLTEELKEIDSVLSTWARLDASFSASSTPTAG
LVGFLSNTSSGGDTWNDEYRCVDASVTKASKVKNGIKFTGPGSMATWLVNSREDNRQYGFVNHSFTLVAT
VTIHQVAKGSTPLLGAGLDAPVSTNFIGLSYSMDKRWETVFYGKKTTSNTTWELGKEYQVALMLQDGNKG
SVYVDGVIVGSPENITKLGALGHEIAHFYFGGDEGYINSSVTVTNVFLYNRPLSVGELKMVRKSDDKKGN
GGD

Epitope Information

IEDB Linear Epitope