VIOLIN: Vaccine Investigation and Online Information Network

LcrV

General Information

Protegen ID

790

Sequence Strain (Species/Organism)

Yersinia enterocolitica

VO ID

VO_0011321

Taxonomy ID

630

Molecule Role

Protective antigen

Molecule Role Annotation

Mice actively immunized using a recombinant V antigen (rVagHis, encoded by lcrV gene) of Y. enterocolitica were completely protected against challenge with both, Y. enterocolitica 0:8 and Y. pseudotuberculosis serotype III (Schmidt et al., 1999).

Related Vaccines(s)

Y. enterocolititica Subunit V Antigen Protein Vaccine

References

Schmidt et al., 1999: Schmidt A, Schaffelhofer S, MÃ¼ller K, RÃ¶llinghoff M, Beuscher HU. Analysis of the Yersinia enterocolitica 0:8 V antigen for cross protectivity. Microbial pathogenesis. 1999; 26(4); 221-233. [PubMed: 10089162].

Gene Information

Gene Name

LcrV

NCBI Gene ID

1449458

Genbank Accession

CP009845

Locus Tag

pYVe8081_p09

Plasmid No

pYVe8081

Gene Starting Position

12283

Gene Ending Position

13257

DNA Sequence

>NC_005017.1:12283-13257 Yersinia enterocolitica 8081 plasmid pYVe8081, complete sequence
ATTACCTCGTGTCATCTAGCAGACGTTGCATTACTGAATCATATTTCTGAATGAAACGGTTCAGTGCTTC
AATAGCTGAATTAAAACGTGATGTAATATCAGACAGCTGAGTTGTTTTTTGGCTAACCAAGTCGTTGAGC
GGCCTGGACTTATCCGAGCAGGCGGTGGCAAAGTGAGATAATTCATTATTATCTTTATTATAAGAGTATG
AATTTTTCAGGTTACCCAACGCCCCGGTTCTTTTATTCTCACTTTCAAGAAAGTTCTTTATCGAGACTAT
TTTTTTTTCGGTCTCACCTTCCTTAATGGTGGTTTGAGACATTTTCTCAAGAATTTTGTACTCTGCGCTG
GCTTTAAAAATCTCTTCATCTGTATAACCATATAAATTTTTATCCATGAGATTAATTGATTTATCATGGA
TATTTATGGTGCCACTATTCGACAGATACTTATTAATTTCAGCTTGAATAACTGAATAAATTTTTAATTC
GGCGGTAAGCTCAGCTAATTCTTCACGCAACTTGCTACGGGCATCACCATGATGATTCATTGAATCAACA
ATCACTTTCAAAATATCATCATCGATACGATCGGCGGTTAAAGAGAAATGCATTACTGCCATGAACGCTC
GCAACTCCCATTGTGTATTCGGCGATGATTCAAGGAACTCTTTTACTCGCTTGATGCCATTTTGCAGTTG
GTTGTCATAATGACCGCCTTTAAGAATGGCATCCTCGGGTAGAAAATAAGCCAGGATTTTCTTGAGTAAT
TCGATATCATCAGTAATTACCCTTTCGGCAAAAACCTCCGAATCTTTTTTGGGATCATATTTAATGGAAA
TATCTATCTTTTTATCTTTGACTAACTGAACCAATTCTTCTAAAACTGAAGAACCATGACCAGTAAGTTG
TTCCACCCTAACTTTTTCTAGATCCTCAATAAAATGTTGTGGGTTTTGTTCGTAGGCTCTAATCA

Protein Information

Protein Name

LcrV

NCBI Protein GI

32470278

Protein Accession

NP_863514

Protein pI

5.5

Protein Weight

35777.8

Protein Length

324

Protein Sequence

>NP_863514.1 LcrV (plasmid) [Yersinia enterocolitica]
MIRAYEQNPQHFIEDLEKVRVEQLTGHGSSVLEELVQLVKDKKIDISIKYDPKKDSEVFAERVITDDIEL
LKKILAYFLPEDAILKGGHYDNQLQNGIKRVKEFLESSPNTQWELRAFMAVMHFSLTADRIDDDILKVIV
DSMNHHGDARSKLREELAELTAELKIYSVIQAEINKYLSNSGTINIHDKSINLMDKNLYGYTDEEIFKAS
AEYKILEKMSQTTIKEGETEKKIVSIKNFLESENKRTGALGNLKNSYSYNKDNNELSHFATACSDKSRPL
NDLVSQKTTQLSDITSRFNSAIEALNRFIQKYDSVMQRLLDDTR

Epitope Information

IEDB Linear Epitope