VIOLIN: Vaccine Investigation and Online Information Network

CEL-170/4

General Information

Protegen ID

795

Sequence Strain (Species/Organism)

Entamoeba histolytica

VO ID

VO_0011326

Taxonomy ID

5759

Molecule Role

Protective antigen

Molecule Role Annotation

Researcherse tested the ability of the galactose-specific adherence lectin of E. histolytica to elicit a protective immune response in conjunction with Freund's incomplete and complete adjuvants. Four independent trials demonstrated complete protection from amebic liver abscess formation in 67% of lectin-immunized gerbils. The gerbil antilectin antibodies were shown by Western immunoblotting to be directed to the heavy subunit (CEL-170/4) but not the light subunit of the lectin (Petri and Ravdin, 1991).

Related Vaccines(s)

E. histolytica CEL-170/4 protein vaccine

References

Petri and Ravdin, 1991: Petri WA Jr, Ravdin JI. Protection of gerbils from amebic liver abscess by immunization with the galactose-specific adherence lectin of Entamoeba histolytica. Infection and immunity. 1991; 59(1); 97-9101. [PubMed: 1987067].

Gene Information

Gene Name

CEL-170/4

Protein Information

Protein Name

170 kDa surface lectin

NCBI Protein GI

401088

Protein pI

4.96

Protein Weight

138236.38

Protein Length

1384

Protein Note

{ECO:0000269|PubMed:2000392, ECO:0000269|PubMed:2536731}.

Protein Sequence

>sp|P23502.2|SL17_ENTHI RecName: Full=170 kDa surface lectin; Flags: Precursor
MKLLLLNILLLCCLADKLNEFSADIDYYDLGIMSRGKNAGSWYHSYTHQYDVFYYLAMQPWRHFVWTTCE
TTKGNKECYKYIINEDHNLNAQQLNNIKNLDKQDFCQKEYAYPIEKYEVDWDNVPVDEQQIESVDINGKT
CFKYAAKRPLAYVYLNTKMTYATKTEAYDVCRMDFIGGRSITFRSFNNENKDFIDQYNTNTTSKCIIDVH
KNNVNTHLAIILGITDSTVIKSLQENLSLLSQLKQSRVTLYYLKDDSYATDNIKLKDLKYETLVKYTAGQ
GQVDPLVNQAKNDLFKMISDKKIKRGTMVVLMDNALGSEFNAETEFDRKNISVHTVVLNRNKDSKITYSA
LKLVSLGPHYHEFTSNSEVSTTIDELFKGIRANLTERCDRDKCSGFCDAMNRCTCPMCCENDCFYTSCDV
ETGSCIPWPKAKPKAKKECPATCVGLYECKDLEGCVVTKYNASCEPKVKCMVPYCDDDNNLKEVCKQKAN
CEADQKPSSDGYCWSYTCDETTGFCKKYKHGNLCTGKTTNCQEYVCDSEQRCTVQEKVCVKTSPYIEMSC
YVAKCNLNTGMCENRLSCDTYSSCGGDSTGSVCKCDASTGNQCKCNKVENGNYCDSSKHEICDYTGDKPK
CIVSECTEDLVRDGCLIKRCNKTSKTTYWENVDCSNTKIEFAQDGKSETMCKPYYSATCLNGQCVVQAVG
DVSNVGCGYCSMGTDNVITYHDDCDSRKSQCGNFNGKCQPNGDNSYSCVFEKDKTSSKSDNDICAECSSL
TCPADTTYRTYTYDSKTGTCKATVKPTPSCSVCEKGKFVEKSKDQKLERKVTLEDGKEYQYNIPKDCVNE
QCIPRTYVDCLANDDNFGEIYKFYLPCQAYVTATYHYSSLFNLTSYKLHLPQSEEFMKEADKEAYCTYEI
TTRECKTCSLTETKEKVEEIDLCAEETKNGGVPFKCKNNNCIIDPNFDCQPIECKIQEIVITEKDGIKTT
TCKDGTKTTCDTNNKRIEDARKAFIEGKEGIEQVECASTVCQNDNSCPIIADVEKCNQNTEVDYGCKAMT
GECDGTTYLCKFVQLTDDPSLDSEHFRTKSGVELNNACLKYKCVESKGSDGKITHKWEIDTERSNIDPKP
RNPCETATCDQTTGETIYTKKTCTVSEEFPTITPNQGRCFYCQCSYLDGSSVLTMYGETDKEYYDLDACG
NCRVWNQTDRTQQLNNHTECILAGEINNVGAIAAATTVAVVVVAVVVALIVVSIGLFKTYQLVSSAMKNA
ITTTNENAEYVGADNEATNAATYNG

Epitope Information

IEDB Linear Epitope