VIOLIN: Vaccine Investigation and Online Information Network

hspB

General Information

Protegen ID

826

Sequence Strain (Species/Organism)

Helicobacter pylori 85P

VO ID

VO_0012378

Taxonomy ID

210

Other Database IDs

CDD:234573
CDD:237231
CDD:239460

Molecule Role

Protective antigen

Molecule Role Annotation

Orogastric immunization of mice with recombinant H. pylori HspB proteins protected 70% of animals from a challenge dose of 10^4 Helicobacter felis bacteria (Ferrero et al., 1995).

Related Vaccines(s)

H. pylori DNA vaccine pcDNA3.1-hspB , H. pylori HspB Protein Vaccine

References

Ferrero et al., 1995: Ferrero RL, Thiberge JM, Kansau I, Wuscher N, Huerre M, Labigne A. The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice. Proceedings of the National Academy of Sciences of the United States of America. 1995; 92(14); 6499-6503. [PubMed: 7604021].

Gene Information

Gene Name

hspB

Protein Information

Protein Name

heat shock protein

NCBI Protein GI

712831

Protein pI

5.47

Protein Weight

53926.66

Protein Length

607

Protein Note

chaperonin GroEL; Reviewed; PRK00013

Protein Sequence

>AAC41441.1 heat shock protein [Helicobacter pylori]
MAKEIKFSDSARNLLFEGVRQLHDAVKVTMGPRGRNVLIQKSYGAPSITKDGVSVAKEIELSCPVANMGA
QLVKEDASKTADAAGDGTTTATVLAYSIFKEGLRNITAGANPIEVKRGMDKAPEAIINELKKASKKVGGK
EEITQVATISANSDHNIGKLIADAMEKVGKDGVITVEEAKGIEDELDVVEGMQFDRGYLSPYFVTNAEKM
TAQLDNAYILLTDKKISSMKDILPLLEKTMKEGKPLLIIAEDIEGEALTTLVVNKLRGVLNIAAVKAPGF
GDRRKEMLKDIAVLTGGQVISEELGLSLENAEVEFLGKAKIVIDKDNTTIVDGKGHSHDVKDRVAQIKTQ
IASTTSDYDKEKLQERLAKLSGGVAVIKVGAASEVEMKEKKDRVDDALSATKAAVEEGIVIGGGAALIRA
AQKVHLNLHDDEKVGYEIIMRAIKAPLAQIAINAGYDGGVVVNEVEKHEGHFGFNASNGKYVDMFKEGII
DPLKVERIALQNAVSVSSLLLTTEATVHEIKEEKAAPAMPDMGGMGGMGGMGGMM

Epitope Information

IEDB Linear Epitope