VIOLIN: Vaccine Investigation and Online Information Network

OspA

General Information

Protegen ID

838

Sequence Strain (Species/Organism)

Borrelia burgdorferi B31

VO ID

VO_0012384

Taxonomy ID

224326

Molecule Role

Protective antigen

Molecule Role Annotation

Mice immunized with recombinant OspA protein were protected from challenge with Borrelia burgdorferi (Probert and LeFebvre, 1994).

Related Vaccines(s)

B. burgdorferi DbpA and OspA Protein Vaccine , B. burgdorferi DNA vaccine encoding strain B31 OspA , B. burgdorferi OspA Protein Vaccine

References

Probert and LeFebvre, 1994: Probert WS, LeFebvre RB. Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen. Infection and immunity. 1994; 62(5); 1920-1926. [PubMed: 8168958].

Gene Information

Gene Name

OspA

NCBI Gene ID

1194357

Genbank Accession

AE000790

Locus Tag

BB_A15

Plasmid No

lp54

Gene Starting Position

9456

Gene Ending Position

10277

DNA Sequence

>NC_001857.2:9456-10277 Borrelia burgdorferi B31 plasmid lp54, complete sequence
TATGAAAAAATATTTATTGGGAATAGGTCTAATATTAGCCTTAATAGCATGTAAGCAAAATGTTAGCAGC
CTTGACGAGAAAAACAGCGTTTCAGTAGATTTGCCTGGTGAAATGAAAGTTCTTGTAAGCAAAGAAAAAA
ACAAAGACGGCAAGTACGATCTAATTGCAACAGTAGACAAGCTTGAGCTTAAAGGAACTTCTGATAAAAA
CAATGGATCTGGAGTACTTGAAGGCGTAAAAGCTGACAAAAGTAAAGTAAAATTAACAATTTCTGACGAT
CTAGGTCAAACCACACTTGAAGTTTTCAAAGAAGATGGCAAAACACTAGTATCAAAAAAAGTAACTTCCA
AAGACAAGTCATCAACAGAAGAAAAATTCAATGAAAAAGGTGAAGTATCTGAAAAAATAATAACAAGAGC
AGACGGAACCAGACTTGAATACACAGGAATTAAAAGCGATGGATCTGGAAAAGCTAAAGAGGTTTTAAAA
GGCTATGTTCTTGAAGGAACTCTAACTGCTGAAAAAACAACATTGGTGGTTAAAGAAGGAACTGTTACTT
TAAGCAAAAATATTTCAAAATCTGGGGAAGTTTCAGTTGAACTTAATGACACTGACAGTAGTGCTGCTAC
TAAAAAAACTGCAGCTTGGAATTCAGGCACTTCAACTTTAACAATTACTGTAAACAGTAAAAAAACTAAA
GACCTTGTGTTTACAAAAGAAAACACAATTACAGTACAACAATACGACTCAAATGGCACCAAATTAGAGG
GGTCAGCAGTTGAAATTACAAAACTTGATGAAATTAAAAACGCTTTAAAATA

Protein Information

Protein Name

outer surface protein A

NCBI Protein GI

11496927

Protein Accession

NP_045688

3D structure: PDB ID

2HKD

Protein pI

9.36

Protein Weight

26986.42

Protein Length

273

Protein Note

similar to SP:P14013 GB:L23137 GB:L23138 GB:L23139 GB:L23140 percent identity: 98.90; identified by sequence similarity; putative

Protein Sequence

>NP_045688.1 outer surface protein A (plasmid) [Borreliella burgdorferi B31]
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKN
NGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRA
DGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAAT
KKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK

Epitope Information

IEDB Linear Epitope