VIOLIN: Vaccine Investigation and Online Information Network

OspC

General Information

Protegen ID

840

Sequence Strain (Species/Organism)

Borrelia burgdorferi B31

VO ID

VO_0012386

Taxonomy ID

224326

Molecule Role

Protective antigen

Molecule Role Annotation

Mice immunized with recombinant OspC protein were protected from challenge with Borrelia burgdorferi (Probert and LeFebvre, 1994).

Related Vaccines(s)

B. burgdorferi DNA vaccine pCMV-ZS7/TPA encoding OspC from Borrelia burgdorferi sensu lato , B. burgdorferi OspC Protein Vaccine

References

Probert and LeFebvre, 1994: Probert WS, LeFebvre RB. Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen. Infection and immunity. 1994; 62(5); 1920-1926. [PubMed: 8168958].

Gene Information

Gene Name

OspC

NCBI Gene ID

1194415

Genbank Accession

AE000792

Locus Tag

BB_B19

Plasmid No

cp26

Gene Starting Position

16902

Gene Ending Position

17534

DNA Sequence

>NC_001903.1:16902-17534 Borrelia burgdorferi B31 plasmid cp26, complete sequence
AATGAAAAAGAATACATTAAGTGCAATATTAATGACTTTATTTTTATTTATATCTTGTAATAATTCAGGG
AAAGATGGGAATACATCTGCAAATTCTGCTGATGAGTCTGTTAAAGGGCCTAATCTTACAGAAATAAGTA
AAAAAATTACGGATTCTAATGCGGTTTTACTTGCTGTGAAAGAGGTTGAAGCGTTGCTGTCATCTATAGA
TGAAATTGCTGCTAAAGCTATTGGTAAAAAAATACACCAAAATAATGGTTTGGATACCGAAAATAATCAC
AATGGATCATTGTTAGCGGGAGCTTATGCAATATCAACCCTAATAAAACAAAAATTAGATGGATTGAAAA
ATGAAGGATTAAAGGAAAAAATTGATGCGGCTAAGAAATGTTCTGAAACATTTACTAATAAATTAAAAGA
AAAACACACAGATCTTGGTAAAGAAGGTGTTACTGATGCTGATGCAAAAGAAGCCATTTTAAAAACAAAT
GGTACTAAAACTAAAGGTGCTGAAGAACTTGGAAAATTATTTGAATCAGTAGAGGTCTTGTCAAAAGCAG
CTAAAGAGATGCTTGCTAATTCAGTTAAAGAGCTTACAAGCCCTGTTGTGGCAGAAAGTCCAAAAAAACC
TTA

Protein Information

Protein Name

outer surface protein C

NCBI Protein GI

11497024

Protein Accession

NP_047005

3D structure: PDB ID

1GGQ

Protein pI

8.68

Protein Weight

21347.6

Protein Length

210

Protein Note

similar to GB:AE000792 percent identity: 100.00; identified by sequence similarity; putative

Protein Sequence

>NP_047005.1 outer surface protein C (plasmid) [Borreliella burgdorferi B31]
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSID
EIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKE
KHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP

Epitope Information

IEDB Linear Epitope