VIOLIN: Vaccine Investigation and Online Information Network

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Gene Name	pagA
Sequence Strain (Species/Organism)	Bacillus anthracis
VO ID	VO_0011029
NCBI Protein GI	9280533
3D structure: PDB ID	1ACC
Other Database IDs	ATCC:14185 CDD:311565 CDD:281492
Taxonomy ID	1392
Gene Strand (Orientation)	?
Protein Name	protective antigen
Protein pI	6.09
Protein Weight	81760.71
Protein Length	838
Protein Note	PA14 domain; pfam07691
Protein Sequence	>AAF86457.1 protective antigen (plasmid) [Bacillus anthracis] MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTG DLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKG RLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDND GIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEA RHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVS AGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTL ATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIAT YNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAF GFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNVTNIYTVLDKIKLNAKMNILIRDKRFHYDRN NIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQD GKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG
Molecule Role	Protective antigen
Molecule Role Annotation	Study described the construction and evaluation of an adenovirus vaccine expressing domain 4 of Bacillus anthracis protective antigen, Ad.D4. Ad.D4 elicited antibodies to protective antigen 14 days after a single intramuscular injection, which were further increased upon boosting. Furthermore, two doses of Ad.D4 4 weeks apart were sufficient to protect 67% of mice from toxin challenge (McConnell et al., 2006).
Related Vaccines(s)	B. anthracis DNA Vaccine expressing PA , B. anthracis DNA vaccine PA , B. anthracis DNA vaccine pCPA , B. anthracis DNA vaccine pIMS-120 encoding PA , pCMV/ER-PA83 , rLAG- PA-DCpep
References

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